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- Pharmacology For Cisapride + Simethicone
Cisapride + Simethicone Pharmacology
Cisapride + SimethiconeAbout Cisapride + SimethiconeN/AMechanism of Action of Cisapride + SimethiconeN/APharmacokinets of Cisapride + SimethiconeN/AOnset of Action for Cisapride + SimethiconeN/ADuration of Action for Cisapride + SimethiconeN/AHalf Life of Cisapride + SimethiconeN/ASide Effects of Cisapride + SimethiconeN/AContra-indications of Cisapride + SimethiconeN/ASpecial Precautions while taking Cisapride + SimethiconeN/APregnancy Related InformationContraindicated; since Cisapride is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cisapride + Simethicone1.Functional dyspepsia
2.Gastro esophageal reflux disease
Interactions for Cisapride + SimethiconeN/ATypical Dosage for Cisapride + SimethiconeAdult: 1 tablet to be taken 15minutes before each meal and at bed time.Schedule of Cisapride + SimethiconeN/AStorage Requirements for Cisapride + SimethiconeN/AEffects of Missed Dosage of Cisapride + SimethiconeN/AEffects of Overdose of Cisapride + SimethiconeN/A
CisaprideAbout CisaprideA serotonin 5-HT4 receptor agonist, parasympathomimetic, Gastrointestinal prokinetic agent.Mechanism of Action of CisaprideCisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of CisaprideAbsorption: Cisapride is well absorbed after oral administration.
Distribution: It is very rapidly distributed in the body mainly to tissues in protein bound forms.
Metabolism: Cisapride is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and faeces.
Onset of Action for Cisapride30 - 60 minutesDuration of Action for Cisapride7 - 10 hoursHalf Life of Cisapride6 - 12 hoursSide Effects of Cisapride1.Diarrhoea
Contra-indications of Cisapride1.Hypersensitivity to Cisapride
5.Torsades de pointes
6.Ischaemic heart diseases
7.Congestive heart failure
Special Precautions while taking Cisapride1.Hepatic impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: use with cautionIndications for Cisapride1.Gastroesophageal reflux diseases
3.Non ulcer dyspepsia
4.Disorders associated with decreased gastric motility
Interactions for CisaprideDiazepam: Enhanced efficacy by cisapride due to increased gastric emptying.
Alcohol: Sedative effect augmented.
Anti-convulsants: Plasma levels of anticonvulsants must be carefully montiored.
Anti-coagulants: Prothrombin time increased.
Anti-cholinergics: Antagonize the effects of cisapride.
Typical Dosage for CisaprideAdult:
Oral: 40 mg / day in 4 divided doses 15 minutes before each meal and at bed time. Dose can be increased if needed to 80 mg / day.
Non ulcer dyspepsia: 30 mg / day in 3 divided doses for 1 month.
Gastroesophageal reflux diseases: 30 mg / day in 3 divided doses for 3 months and if needed additional 10 mg can be given at bed time.
Disorders associated with decreased gastric motility: 30 - 40 mg / day in 3 - 4 divided doses for 1 ? months.
Chronic constipation: 15 mg / day in 3 divided doses; dose can be increased to 30 mg / day if necessary.
Children (suspension only): 0.2 mg 3 times daily, maximum daily dose is 0.8 mg / kg / day.
Schedule of CisaprideN/AStorage Requirements for CisaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of CisaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CisaprideGive supportive measures and symptomatic treatment.
Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal.
SimethiconeAbout SimethiconeOral anti-foaming agent, Silicones, Antiflatulent.Mechanism of Action of SimethiconeThis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.Pharmacokinets of SimethiconeExcretion- Excreted through feces.Onset of Action for SimethiconeN/ADuration of Action for SimethiconeN/AHalf Life of SimethiconeN/ASide Effects of Simethicone1. Bloating
Contra-indications of Simethicone1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Simethicone1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for SimethiconeN/ATypical Dosage for SimethiconeOral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of SimethiconeN/AStorage Requirements for SimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of SimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SimethiconeGive symptomatic and supportive treatment.
Home Delivery for Cisapride + Simethicone in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cisapride + simethicone and other medicines and health products. Home delivery services for cisapride + simethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cisapride + simethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cisapride + simethicone before they complete the sale. You can get this information while placing the order for cisapride + simethicone with the pharmacy.
Cisapride + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for cisapride + simethicone might be better known than cisapride + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisapride + simethicone in stock, you can ask for one of the branded alternatives for cisapride + simethicone.