Cisapride + Simethicone Pharmacology

Cisapride + Simethicone

About Cisapride + Simethicone
N/A
Mechanism of Action of Cisapride + Simethicone
N/A
Pharmacokinets of Cisapride + Simethicone
N/A
Onset of Action for Cisapride + Simethicone
N/A
Duration of Action for Cisapride + Simethicone
N/A
Half Life of Cisapride + Simethicone
N/A
Side Effects of Cisapride + Simethicone
N/A
Contra-indications of Cisapride + Simethicone
N/A
Special Precautions while taking Cisapride + Simethicone
N/A
Pregnancy Related Information
Contraindicated; since Cisapride is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Use with caution
Children Related Information
N/A
Indications for Cisapride + Simethicone
1.Functional dyspepsia
2.Gastro esophageal reflux disease
Interactions for Cisapride + Simethicone
N/A
Typical Dosage for Cisapride + Simethicone
Adult: 1 tablet to be taken 15minutes before each meal and at bed time.
Schedule of Cisapride + Simethicone
N/A
Storage Requirements for Cisapride + Simethicone
N/A
Effects of Missed Dosage of Cisapride + Simethicone
N/A
Effects of Overdose of Cisapride + Simethicone
N/A

Cisapride

About Cisapride
A serotonin 5-HT4 receptor agonist, parasympathomimetic, Gastrointestinal prokinetic agent.
Mechanism of Action of Cisapride
Cisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Cisapride
Absorption: Cisapride is well absorbed after oral administration.
Distribution: It is very rapidly distributed in the body mainly to tissues in protein bound forms.
Metabolism: Cisapride is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and faeces.
Onset of Action for Cisapride
30 - 60 minutes
Duration of Action for Cisapride
7 - 10 hours
Half Life of Cisapride
6 - 12 hours
Side Effects of Cisapride
1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Constipation
5.Nausea
6.Urinary frequency
7.Rhinitis
8.Cough
Contra-indications of Cisapride
1.Hypersensitivity to Cisapride
2.Ventricular tachycardia
3.Ventricular fibrillation
4.Ventricular arrhythmia
5.Torsades de pointes
6.Ischaemic heart diseases
7.Congestive heart failure
8.Hypokalaemia
9.Respiratory failure
10.Hypokalaemia
11.Hypomagnesaemia
12.Respiratory failure
13.Renal failure
14.Gastrointestinal haemorrhag

Special Precautions while taking Cisapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: use with caution
Indications for Cisapride
1.Gastroesophageal reflux diseases
2.Gastroparesis
3.Non ulcer dyspepsia
4.Disorders associated with decreased gastric motility
5.Chronic constipation
6.Nausea
Interactions for Cisapride
Diazepam: Enhanced efficacy by cisapride due to increased gastric emptying.
Alcohol: Sedative effect augmented.
Anti-convulsants: Plasma levels of anticonvulsants must be carefully montiored.
Anti-coagulants: Prothrombin time increased.
Anti-cholinergics: Antagonize the effects of cisapride.
Typical Dosage for Cisapride
Adult:
Oral: 40 mg / day in 4 divided doses 15 minutes before each meal and at bed time. Dose can be increased if needed to 80 mg / day.
Non ulcer dyspepsia: 30 mg / day in 3 divided doses for 1 month.
Gastroesophageal reflux diseases: 30 mg / day in 3 divided doses for 3 months and if needed additional 10 mg can be given at bed time.
Disorders associated with decreased gastric motility: 30 - 40 mg / day in 3 - 4 divided doses for 1 ? months.
Chronic constipation: 15 mg / day in 3 divided doses; dose can be increased to 30 mg / day if necessary.
Children (suspension only): 0.2 mg 3 times daily, maximum daily dose is 0.8 mg / kg / day.
Schedule of Cisapride
N/A
Storage Requirements for Cisapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Cisapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Cisapride
Give supportive measures and symptomatic treatment.
Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal.

Simethicone

About Simethicone
Oral anti-foaming agent, Silicones, Antiflatulent.
Mechanism of Action of Simethicone
This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.
Pharmacokinets of Simethicone
Excretion- Excreted through feces.
Onset of Action for Simethicone
N/A
Duration of Action for Simethicone
N/A
Half Life of Simethicone
N/A
Side Effects of Simethicone
1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone
1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone
1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Simethicone
1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for Simethicone
N/A
Typical Dosage for Simethicone
Oral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of Simethicone
N/A
Storage Requirements for Simethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Simethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Simethicone
Give symptomatic and supportive treatment.

Home Delivery for Cisapride + Simethicone in Your City

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Cisapride + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for cisapride + simethicone might be better known than cisapride + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisapride + simethicone in stock, you can ask for one of the branded alternatives for cisapride + simethicone.