Mosapride + Simethicone Pharmacology

Mosapride + Simethicone

About Mosapride + Simethicone
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Mechanism of Action of Mosapride + Simethicone
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Pharmacokinets of Mosapride + Simethicone
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Onset of Action for Mosapride + Simethicone
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Duration of Action for Mosapride + Simethicone
N/A
Half Life of Mosapride + Simethicone
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Side Effects of Mosapride + Simethicone
N/A
Contra-indications of Mosapride + Simethicone
N/A
Special Precautions while taking Mosapride + Simethicone
N/A
Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Mosapride + Simethicone
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Interactions for Mosapride + Simethicone
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Typical Dosage for Mosapride + Simethicone
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Schedule of Mosapride + Simethicone
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Storage Requirements for Mosapride + Simethicone
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Effects of Missed Dosage of Mosapride + Simethicone
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Effects of Overdose of Mosapride + Simethicone
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Mosapride

About Mosapride
A selective 5HT4 agonist, A gastroprokinetic agent.
Mechanism of Action of Mosapride
Mosapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Mosapride produces 5HT3 receptor antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.
Pharmacokinets of Mosapride
Absorption:It is absorbed after oral administration.Excretion: It is excreted mainly urine and faeces.

Onset of Action for Mosapride
N/A
Duration of Action for Mosapride
N/A
Half Life of Mosapride
2 - 3 hours
Side Effects of Mosapride
1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Dry mouth
5.Nausea
Contra-indications of Mosapride
1.Hypersensitivity to Mosapride
Special Precautions while taking Mosapride
1.Hepatic impairment
2.Renal impairment
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Mosapride
1.Gastroesophageal reflux diseases
2.Functional dyspepsia
3.Diabetic gastropathy
4.Disorders associated with decreased gastric motility
5.Nausea
Interactions for Mosapride
Mosapride`s major degradation system is the cytochrome P450 (3A4) system. However, electrophysiological studies show that coadministration of drugs that inhibit the CYP 3A4 enzymes (erythromycin, ketoconazole, fluconazole, etc.) have no effect on mosapride indicating that a satisfactory safety margin exists in relation to rhythm abnormalities, unlike that which occurs with cisapride.
Typical Dosage for Mosapride
Adult:
Oral:2.5 - 10 mg every 6 - 8 hours in a day with meals
Children:not recommended
Schedule of Mosapride
N/A
Storage Requirements for Mosapride
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Mosapride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mosapride
Give supportive measures and symptomatic treatment.

Simethicone

About Simethicone
Oral anti-foaming agent, Silicones, Antiflatulent.
Mechanism of Action of Simethicone
This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.
Pharmacokinets of Simethicone
Excretion- Excreted through feces.
Onset of Action for Simethicone
N/A
Duration of Action for Simethicone
N/A
Half Life of Simethicone
N/A
Side Effects of Simethicone
1. Bloating
2. Constipation
3. Diarrhea
4. Gas
5. Heartburn
Contra-indications of Simethicone
1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone
1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Simethicone
1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for Simethicone
N/A
Typical Dosage for Simethicone
Oral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Chewable tablets:
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Suspension:
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of Simethicone
N/A
Storage Requirements for Simethicone
Stored at room temperature (15-30?C) away from moisture and heat.
Effects of Missed Dosage of Simethicone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Simethicone
Give symptomatic and supportive treatment.

Home Delivery for Mosapride + Simethicone in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mosapride + simethicone and other medicines and health products. Home delivery services for mosapride + simethicone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mosapride + simethicone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mosapride + simethicone before they complete the sale. You can get this information while placing the order for mosapride + simethicone with the pharmacy.

Mosapride + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for mosapride + simethicone might be better known than mosapride + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mosapride + simethicone in stock, you can ask for one of the branded alternatives for mosapride + simethicone.