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- Pharmacology For Cisapride + Methyl Polysiloxane
Cisapride + Methyl Polysiloxane Pharmacology
Cisapride + Methyl Polysiloxane
About Cisapride + Methyl PolysiloxaneN/AMechanism of Action of Cisapride + Methyl PolysiloxaneN/APharmacokinets of Cisapride + Methyl PolysiloxaneN/AOnset of Action for Cisapride + Methyl PolysiloxaneN/ADuration of Action for Cisapride + Methyl PolysiloxaneN/AHalf Life of Cisapride + Methyl PolysiloxaneN/ASide Effects of Cisapride + Methyl PolysiloxaneN/AContra-indications of Cisapride + Methyl PolysiloxaneN/ASpecial Precautions while taking Cisapride + Methyl PolysiloxaneN/APregnancy Related InformationContraindicated; since Cisapride is contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Cisapride + Methyl Polysiloxane1.Functional dyspepsia
2.Gastro esophageal reflux disease
Interactions for Cisapride + Methyl PolysiloxaneN/ATypical Dosage for Cisapride + Methyl PolysiloxaneAdult: 1 tablet to be taken 15minutes before each meal and at bed time.Schedule of Cisapride + Methyl PolysiloxaneN/AStorage Requirements for Cisapride + Methyl PolysiloxaneN/AEffects of Missed Dosage of Cisapride + Methyl PolysiloxaneN/AEffects of Overdose of Cisapride + Methyl PolysiloxaneN/ACisapride
About CisaprideA serotonin 5-HT4 receptor agonist, parasympathomimetic, Gastrointestinal prokinetic agent.Mechanism of Action of CisaprideCisapride is a Prokinetic drug. It is a 5 HT4 receptor agonist as well as 5HT3 receptor antagonist in the myenteric plexus. Enterochromaffin cells in the gastrointestinal mucosa produces and releases serotonin in response to stimuli (chemical or mechanical stimulation).Serotonin will enhances peristaltic movement by stimulating sensory neurons in the myenteric plexus. Stimulation of 5HT4 receptors will increase the release of Acetylcholine. The metabolite of Cisapride produces 5HT3 antagonism and suppresses the inhibitory transmission in myenteric plexus. These all results in increased oesophageal peristaltic activity, lower oesophageal sphincter tone and enhances intestinal propulsive activity.Pharmacokinets of CisaprideAbsorption: Cisapride is well absorbed after oral administration.
Distribution: It is very rapidly distributed in the body mainly to tissues in protein bound forms.
Metabolism: Cisapride is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and faeces.
Onset of Action for Cisapride30 - 60 minutesDuration of Action for Cisapride7 - 10 hoursHalf Life of Cisapride6 - 12 hoursSide Effects of Cisapride1.Diarrhoea
2.Abdominal cramps
3.Headache
4.Constipation
5.Nausea
6.Urinary frequency
7.Rhinitis
8.Cough
Contra-indications of Cisapride1.Hypersensitivity to Cisapride
2.Ventricular tachycardia
3.Ventricular fibrillation
4.Ventricular arrhythmia
5.Torsades de pointes
6.Ischaemic heart diseases
7.Congestive heart failure
8.Hypokalaemia
9.Respiratory failure
10.Hypokalaemia
11.Hypomagnesaemia
12.Respiratory failure
13.Renal failure
14.Gastrointestinal haemorrhag
Special Precautions while taking Cisapride1.Hepatic impairment
2.Renal impairment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
NEONATES: use with cautionIndications for Cisapride1.Gastroesophageal reflux diseases
2.Gastroparesis
3.Non ulcer dyspepsia
4.Disorders associated with decreased gastric motility
5.Chronic constipation
6.Nausea
Interactions for CisaprideDiazepam: Enhanced efficacy by cisapride due to increased gastric emptying.
Alcohol: Sedative effect augmented.
Anti-convulsants: Plasma levels of anticonvulsants must be carefully montiored.
Anti-coagulants: Prothrombin time increased.
Anti-cholinergics: Antagonize the effects of cisapride.
Typical Dosage for CisaprideAdult:
Oral: 40 mg / day in 4 divided doses 15 minutes before each meal and at bed time. Dose can be increased if needed to 80 mg / day.
Non ulcer dyspepsia: 30 mg / day in 3 divided doses for 1 month.
Gastroesophageal reflux diseases: 30 mg / day in 3 divided doses for 3 months and if needed additional 10 mg can be given at bed time.
Disorders associated with decreased gastric motility: 30 - 40 mg / day in 3 - 4 divided doses for 1 ? months.
Chronic constipation: 15 mg / day in 3 divided doses; dose can be increased to 30 mg / day if necessary.
Children (suspension only): 0.2 mg 3 times daily, maximum daily dose is 0.8 mg / kg / day.
Schedule of CisaprideN/AStorage Requirements for CisaprideStore at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of CisaprideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CisaprideGive supportive measures and symptomatic treatment.
Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal.
Methyl Polysiloxane
About Methyl PolysiloxaneSiloxanes, Antiflatulent.Mechanism of Action of Methyl PolysiloxaneMethyl Polysiloxane relieves flatulence by dispensing and preventing formation of mucus surrounding gas pockets in the gastro-intestinal tract. It lowers the surface tension of the gas bubbles and bringing together all the small bubbles of gas (coalesce) to form a large bubble, which is then expelled. Thus the gas is freed by belching or passing flatus.
Antiflatulents are added to an antacid gum coating to be effective antigas materials and eliminate trapped gas.Pharmacokinets of Methyl PolysiloxaneN/AOnset of Action for Methyl PolysiloxaneN/ADuration of Action for Methyl PolysiloxaneN/AHalf Life of Methyl PolysiloxaneN/ASide Effects of Methyl PolysiloxaneN/AContra-indications of Methyl PolysiloxaneHypersensitivity to Methyl PolysiloxaneSpecial Precautions while taking Methyl PolysiloxaneKidney failurePregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Methyl Polysiloxane1. Flatulent dyspepsia
2. Postoperative distension
3. Gastric Distention
4. Functional digestive disorders
5. Stomach pain
6. Burning
7. Nausea and excess gas (dyspepsia)
Interactions for Methyl PolysiloxaneN/ATypical Dosage for Methyl Polysiloxane125 - 166 mg taken half an hour before food.
Methyl Polysiloxane in a coated chewing gum: 5 mg - 200 mg per piece of coated gum.
With an antacid: 20 mg -50 mg of Methyl Polysiloxane
Schedule of Methyl PolysiloxaneN/AStorage Requirements for Methyl PolysiloxaneStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of Methyl PolysiloxaneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Methyl PolysiloxaneGive symptomatic and supportive treatment.Home Delivery for Cisapride + Methyl Polysiloxane in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cisapride + methyl polysiloxane.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cisapride + methyl polysiloxane and other medicines and health products. Home delivery services for cisapride + methyl polysiloxane may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take cisapride + methyl polysiloxane only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cisapride + methyl polysiloxane before they complete the sale. You can get this information while placing the order for cisapride + methyl polysiloxane with the pharmacy.
Cisapride + Methyl Polysiloxane is a generic medicine name and there are several brands available for it. Some of the brands for cisapride + methyl polysiloxane might be better known than cisapride + methyl polysiloxane itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cisapride + methyl polysiloxane in stock, you can ask for one of the branded alternatives for cisapride + methyl polysiloxane.
