Ibuprofen + Paracetamol + Magnesium Trisilicate Pharmacology

Ibuprofen + Paracetamol + Magnesium Trisilicate

About Ibuprofen + Paracetamol + Magnesium Trisilicate
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Mechanism of Action of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Pharmacokinets of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Onset of Action for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Duration of Action for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Half Life of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Side Effects of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Contra-indications of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Special Precautions while taking Ibuprofen + Paracetamol + Magnesium Trisilicate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Interactions for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Typical Dosage for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Schedule of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Storage Requirements for Ibuprofen + Paracetamol + Magnesium Trisilicate
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Effects of Missed Dosage of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Effects of Overdose of Ibuprofen + Paracetamol + Magnesium Trisilicate
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Ibuprofen

About Ibuprofen
NSAID, a propionic acid derivative, Analgesic and anti-inflammatory.
Mechanism of Action of Ibuprofen
Ibuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.
Pharmacokinets of Ibuprofen
Absorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.
Onset of Action for Ibuprofen
? hours
Duration of Action for Ibuprofen
4-6 hours.
Half Life of Ibuprofen
2 hours
Side Effects of Ibuprofen
1.Nausea
2.Vomiting
3.Diarrhoea
4.Gastrointestinal bleeding
5.Abdominal distress
6.Constipation
7.Peptic ulcer
8.Dyspepsia
9.Headache
10.Drowsiness
11.Blurring of vision
12.Tinnitus
13.Depression
14.Thrombocytopenia
15.Rash
16.Pruritis

Contra-indications of Ibuprofen
1.Hypersensitivity to Ibuprofen and other NSAIDs
2.Peptic ulcer
Special Precautions while taking Ibuprofen
1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Gastrointestinal diseases
5.Pre existing asthma
6.Bleeding disorders
7.Phenylketonuria
8.Oedema
9.Heart failure
10.Myocardial infarction
11.Stroke
Pregnancy Related Information
Use with caution
PREGNANCY in third trimester: contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
CHILDREN below 6 months: contraindicated
Indications for Ibuprofen
1.Rheumatoid arthritis
2.Ankylosing spondylitis
3.Acute gout
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
5.Osteoarthritis
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
7.Dysmenorrhoea
8.Juvenile arthritis
9.Migraine
10.Patent ductus arteriosus(IV)
Interactions for Ibuprofen
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Typical Dosage for Ibuprofen
Adult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day

Schedule of Ibuprofen
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Storage Requirements for Ibuprofen
Store Ibuprofen at 15-30 degree C in a tightly closed light resistant container.
Effects of Missed Dosage of Ibuprofen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ibuprofen
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.

Paracetamol

About Paracetamol
Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
Mechanism of Action of Paracetamol
Paracetamol has analgesic and antipyretic action.
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Pharmacokinets of Paracetamol
Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
Onset of Action for Paracetamol
30 - 60 minutes
Duration of Action for Paracetamol
6 hours
Half Life of Paracetamol
1-4 hours
Side Effects of Paracetamol
1. Nausea
2. Abdominal distress
3. Allergic reactions
4. Rash
Contra-indications of Paracetamol
1. Hypersensitivity to Paracetamol
Special Precautions while taking Paracetamol
1. Hepatic impairment
2. Renal impairment
3. Hypertension
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES : Contraindicated
Indications for Paracetamol
1. To relieve pain and fever
2. Acute gout
3. Migraine
Interactions for Paracetamol
Cholestyramine: Reduces absorption of paracetamol.
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
Typical Dosage for Paracetamol
Adult:
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Schedule of Paracetamol
H
Storage Requirements for Paracetamol
Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Paracetamol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Paracetamol
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Magnesium Trisilicate

About Magnesium Trisilicate
Mineral, Magnesium compound, Antacid.
Mechanism of Action of Magnesium Trisilicate
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Pharmacokinets of Magnesium Trisilicate
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Onset of Action for Magnesium Trisilicate
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Duration of Action for Magnesium Trisilicate
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Half Life of Magnesium Trisilicate
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Side Effects of Magnesium Trisilicate
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Contra-indications of Magnesium Trisilicate
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Special Precautions while taking Magnesium Trisilicate
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Magnesium Trisilicate
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Interactions for Magnesium Trisilicate
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Typical Dosage for Magnesium Trisilicate
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Schedule of Magnesium Trisilicate
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Storage Requirements for Magnesium Trisilicate
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Effects of Missed Dosage of Magnesium Trisilicate
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Effects of Overdose of Magnesium Trisilicate
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Home Delivery for Ibuprofen + Paracetamol + Magnesium Trisilicate in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ibuprofen + paracetamol + magnesium trisilicate and other medicines and health products. Home delivery services for ibuprofen + paracetamol + magnesium trisilicate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ibuprofen + paracetamol + magnesium trisilicate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ibuprofen + paracetamol + magnesium trisilicate before they complete the sale. You can get this information while placing the order for ibuprofen + paracetamol + magnesium trisilicate with the pharmacy.

Ibuprofen + Paracetamol + Magnesium Trisilicate is a generic medicine name and there are several brands available for it. Some of the brands for ibuprofen + paracetamol + magnesium trisilicate might be better known than ibuprofen + paracetamol + magnesium trisilicate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ibuprofen + paracetamol + magnesium trisilicate in stock, you can ask for one of the branded alternatives for ibuprofen + paracetamol + magnesium trisilicate.