Diphenoxylate Pharmacology

Diphenoxylate

About Diphenoxylate

An opioid agonist,Meperidine analogue, Antidiarrheals.

Mechanism of Action of Diphenoxylate

Diphenoxylate is an opioid agonist. It used for the treatment of diarrhea which acts by slowing down intestinal contractions.It is a Meperidine analogue that inhibits gastrointestinal motility locally and centrally.High doses it may produce opiate effect.

Pharmacokinets of Diphenoxylate

Absorption:About 90% of the drug is absorbed.Distribution: It is distributed in milk. Metabolism:It undergoes metabolism in the liver.Excretion:It is excreted mainly in faeces and small amount in urine.

Onset of Action for Diphenoxylate

N/A

Duration of Action for Diphenoxylate

N/A

Half Life of Diphenoxylate

N/A

Side Effects of Diphenoxylate

1.Sedation
2.Headache
3.Dizziness
4.Respiratory depression
5.Pruritis
6.Rash
7.Restlessness

Contra-indications of Diphenoxylate

1.Hypersensitivity to Diphenoxylate
2.Acute diarrhea
3.Obstructive jaundice

Special Precautions while taking Diphenoxylate

1.Hepatic disease
2.Narcotic dependence
3.Ulcerative colitis
4.Stop immediately if abdominal distension occurs

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution
Below 2 years:Contraindicated

Indications for Diphenoxylate

1.Acute non specific diarrhoea

Interactions for Diphenoxylate

N/A

Typical Dosage for Diphenoxylate

Adult:5 mg to be taken 4 times daily and adjust the dose as required.
Children:
2 - 5 years: 6 mg / day in 3 divided doses
5 - 8 years: 6 mg / day in 4 divided doses
8 - 12 years: 10mg / day in 5 divided doses

Schedule of Diphenoxylate

Storage Requirements for Diphenoxylate

Store iat room temperature.Protect from heat and light.Keep out of the reach of children.

Effects of Missed Dosage of Diphenoxylate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.

Effects of Overdose of Diphenoxylate

Give supportive measures and symptomatic treatment. Gastric lavage can be done to remove the drug from the body.If necessary a narcotic antagonist such as Naloxone may be given.

Home Delivery for Diphenoxylate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including diphenoxylate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for diphenoxylate and other medicines and health products. Home delivery services for diphenoxylate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take diphenoxylate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for diphenoxylate before they complete the sale. You can get this information while placing the order for diphenoxylate with the pharmacy.

Diphenoxylate is a generic medicine name and there are several brands available for it. Some of the brands for diphenoxylate might be better known than diphenoxylate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diphenoxylate in stock, you can ask for one of the branded alternatives for diphenoxylate.