Ornidazole + Ciprofloxacin Pharmacology

Ornidazole + Ciprofloxacin

About Ornidazole + Ciprofloxacin
N/A
Mechanism of Action of Ornidazole + Ciprofloxacin
N/A
Pharmacokinets of Ornidazole + Ciprofloxacin
N/A
Onset of Action for Ornidazole + Ciprofloxacin
N/A
Duration of Action for Ornidazole + Ciprofloxacin
N/A
Half Life of Ornidazole + Ciprofloxacin
N/A
Side Effects of Ornidazole + Ciprofloxacin
N/A
Contra-indications of Ornidazole + Ciprofloxacin
N/A
Special Precautions while taking Ornidazole + Ciprofloxacin
N/A
Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Ornidazole + Ciprofloxacin
N/A
Interactions for Ornidazole + Ciprofloxacin
N/A
Typical Dosage for Ornidazole + Ciprofloxacin
N/A
Schedule of Ornidazole + Ciprofloxacin
N/A
Storage Requirements for Ornidazole + Ciprofloxacin
N/A
Effects of Missed Dosage of Ornidazole + Ciprofloxacin
N/A
Effects of Overdose of Ornidazole + Ciprofloxacin
N/A

Ornidazole

About Ornidazole
A nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.
Mechanism of Action of Ornidazole
Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of Ornidazole
Absorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for Ornidazole
Within 2 hours
Duration of Action for Ornidazole
14hours
Half Life of Ornidazole
12 to 14 hours
Side Effects of Ornidazole
1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.Vertigo
Contra-indications of Ornidazole
1.Hypersensitivity to the drug or other imidazoles
Special Precautions while taking Ornidazole
1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related Information
Use with caution
First trimester: contra indicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
May be used
Children Related Information
Use with caution
Indications for Ornidazole
1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for Ornidazole
N/A
Typical Dosage for Ornidazole
Amoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of Ornidazole
H
Storage Requirements for Ornidazole
Store at cool dry place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Ornidazole
Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ornidazole
Treatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.

Ciprofloxacin

About Ciprofloxacin
It is a broad spectrum fluoroquinolone with activity against Pseudomonas aeruginosa.
EYE DROPS: It is a fluroquinolone antibacterial having broad spectrum of activity.
Mechanism of Action of Ciprofloxacin
Ciprofloxacin is a bacteriostatic at low concentration and bactericidal at high concentration. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ciprofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.
Pharmacokinets of Ciprofloxacin
Absorption: They are adequately absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes hepatic metabolism. Excretion: Drug is excreted mainly through urine.

Onset of Action for Ciprofloxacin
Within 1hr.
Duration of Action for Ciprofloxacin
8-12 hours.
Half Life of Ciprofloxacin
3 - 5 hour
Side Effects of Ciprofloxacin
1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Restlessness
6.Dizziness
7.Drowsiness
8.Arthralgia
9.Rash
10.Confusion
11.Insomnia
12.Anorexia
13.Bad taste
14.Headache
15.Photosensitivity

Contra-indications of Ciprofloxacin
Hypersensitivity to Ciprofloxacin and other Fluoroquinolones
Special Precautions while taking Ciprofloxacin
1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Dehydration
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Ciprofloxacin
1.Urinary tract infection
2.Respiratory tract infection
3.Bone and joint infections,
4.Infectious diarrhoea
5.Gonorrhoea
6.ENT infections
7.Skin and soft tissue infections
8.Typhoid fever
9.Intra-abdominal infections
10.Prostatitis
11. Sinusitis
12.Chancroid
13.Gynaecological infections
14.Tularemia
Interactions for Ciprofloxacin
Antacids (aluminium/magnesium hydroxide), Iron salts, Zinc salts.: Absorption of ciprofloxacin is decreased.
Antineoplastic drugs: Decrease serum levels of ciprofloxacin.
Caffeine: Enhanced efficacy of caffeine.
Oral anti-coagulants: Enhanced efficacy of anti-coagulants.
Cyclosporine: Nephrotoxicity increased by ciprofloxacin.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAIDs: CNS excitation may occur.
Rifampicin: Decreases serum concenteration of ciprofloxacin.
Chloramphenicol: Antagonises effects of ciprofloxacin.
Typical Dosage for Ciprofloxacin
Adults:
Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient.
UTI: 0.5 - 1 g / day in 2 divided doses.
Respiratory tract infection, Bone and joint infections, Infectious diarrhoea, ENT infections, .Skin and soft tissue infections, Enteric fever: 1 - 1.5 g / day in 2 divided doses
Typhoid fever, Intra-abdominal infections, Gynaecological infection: 1 g / day in 2 divided doses
Uncomplicated gonorrhea: 250 mg / day
Schedule of Ciprofloxacin
H
Storage Requirements for Ciprofloxacin
Store at 15 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Ciprofloxacin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Ciprofloxacin
Give supportive measures and symptomatic treatment. Induce emesis or gastric lavage has to be done. Dialysis can be done if necessary.

Home Delivery for Ornidazole + Ciprofloxacin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ornidazole + ciprofloxacin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ornidazole + ciprofloxacin and other medicines and health products. Home delivery services for ornidazole + ciprofloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ornidazole + ciprofloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ornidazole + ciprofloxacin before they complete the sale. You can get this information while placing the order for ornidazole + ciprofloxacin with the pharmacy.

Ornidazole + Ciprofloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole + ciprofloxacin might be better known than ornidazole + ciprofloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole + ciprofloxacin in stock, you can ask for one of the branded alternatives for ornidazole + ciprofloxacin.