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- Pharmacology For Ornidazole + Gatifloxacin
Ornidazole + Gatifloxacin Pharmacology
Ornidazole + Gatifloxacin
About Ornidazole + GatifloxacinN/AMechanism of Action of Ornidazole + GatifloxacinN/APharmacokinets of Ornidazole + GatifloxacinN/AOnset of Action for Ornidazole + GatifloxacinN/ADuration of Action for Ornidazole + GatifloxacinN/AHalf Life of Ornidazole + GatifloxacinN/ASide Effects of Ornidazole + GatifloxacinN/AContra-indications of Ornidazole + GatifloxacinN/ASpecial Precautions while taking Ornidazole + GatifloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + GatifloxacinN/AInteractions for Ornidazole + GatifloxacinN/ATypical Dosage for Ornidazole + GatifloxacinN/ASchedule of Ornidazole + GatifloxacinN/AStorage Requirements for Ornidazole + GatifloxacinN/AEffects of Missed Dosage of Ornidazole + GatifloxacinN/AEffects of Overdose of Ornidazole + GatifloxacinN/AOrnidazole
About OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
2.Vertigo
3.Nausea
4.Vomiting
5.Fatigue
6.Dry mouth
7.Headache
8.Rash
9.Urticaria
10.Abdominal distress
11.Dizziness
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
2.Mental confusion
3.Ataxia
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
2.Giardiasis
3.Trichomonas vaginitis
4.Anaerobic bacterial infections
5.Bacterial vaginosis
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Amoebic dysentery:
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Trichomoniasis
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Giardiasis:
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics. Gatifloxacin
About GatifloxacinFourth-generation fluoroquinolone, DNA Gyrase Inhibitor,Topoisomerase I Inhibitor, Antibiotic.Mechanism of Action of GatifloxacinGatifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Gatifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis in microorganisms.Pharmacokinets of GatifloxacinAbsorption: Gatifloxacin is well absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes limited metabolism. Excretion: Drug is excreted mainly through urine.Onset of Action for GatifloxacinN/ADuration of Action for GatifloxacinN/AHalf Life of Gatifloxacin8 hourSide Effects of Gatifloxacin1.Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Vaginitis
6.Dizziness
7.Headache
Contra-indications of GatifloxacinHypersensitivity to Gatifloxacin and other FluoroquinolonesSpecial Precautions while taking Gatifloxacin1.Hepatic impairment
2.Renal impairment
3.Epilepsy
4.Concomitant use of antiarrhythmic drugs
5.Caution while driving the vehicle or operating machine or involved in any hazardous activities.
6.Avoid long exposure to sunlight.
Pregnancy Related InformationUse with caution
Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: contraindicatedIndications for Gatifloxacin1.Pneumonia
2.Bronchitis
3.Sinusitis
4.Urinary tract infections
5.Pyelonephritis
6.Skin and skin structure infections
7.Gonorrhoea.
Interactions for GatifloxacinProbenicid : Systemic exposure to gatifloxacin is increased following concomitant administration of gatifloxacin and probenicid.
Ferrous sulphate /Antacid : Systemic exposure is reduced when gatifloxacin is given concomitantly with Ferrous sulphate or with antacids containing aluminium or magnesium salts.
Typical Dosage for GatifloxacinAdults: 400 mg once daily for 1 - 2 week
Dose is determined on the basis of severity of the infection and type of infecting organism
Bronchitis: 400 mg once daily for 5 days
Sinusitis: 400 mg once daily for 10 days
Pneumonia: 400 mg once daily for 1 - 2 week
Skin and skin structure infections, Complicated UTI, Pyelonephritis: 400 mg once daily for 7 - 10 days
Uncomplicated UTI: 200 mg / day for 3 days
Gonorrhoea: 400 mg as a single dose.
Schedule of GatifloxacinHStorage Requirements for GatifloxacinStore at room temperature in a tightly closed container.Effects of Missed Dosage of GatifloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of GatifloxacinGive supportive measures and symptomatic treatment. Home Delivery for Ornidazole + Gatifloxacin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ornidazole + gatifloxacin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ornidazole + gatifloxacin and other medicines and health products. Home delivery services for ornidazole + gatifloxacin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take ornidazole + gatifloxacin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ornidazole + gatifloxacin before they complete the sale. You can get this information while placing the order for ornidazole + gatifloxacin with the pharmacy.
Ornidazole + Gatifloxacin is a generic medicine name and there are several brands available for it. Some of the brands for ornidazole + gatifloxacin might be better known than ornidazole + gatifloxacin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ornidazole + gatifloxacin in stock, you can ask for one of the branded alternatives for ornidazole + gatifloxacin.
