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- Pharmacology For Ornidazole + Ofloxacin
Ornidazole + Ofloxacin Pharmacology
Ornidazole + OfloxacinAbout Ornidazole + OfloxacinN/AMechanism of Action of Ornidazole + OfloxacinN/APharmacokinets of Ornidazole + OfloxacinN/AOnset of Action for Ornidazole + OfloxacinN/ADuration of Action for Ornidazole + OfloxacinN/AHalf Life of Ornidazole + OfloxacinN/ASide Effects of Ornidazole + OfloxacinN/AContra-indications of Ornidazole + OfloxacinN/ASpecial Precautions while taking Ornidazole + OfloxacinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + OfloxacinN/AInteractions for Ornidazole + OfloxacinN/ATypical Dosage for Ornidazole + OfloxacinN/ASchedule of Ornidazole + OfloxacinN/AStorage Requirements for Ornidazole + OfloxacinN/AEffects of Missed Dosage of Ornidazole + OfloxacinN/AEffects of Overdose of Ornidazole + OfloxacinN/A
OrnidazoleAbout OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
4.Anaerobic bacterial infections
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.
OfloxacinAbout OfloxacinA second generation fluoroquinolone(quinolones), Antibiotic.Mechanism of Action of OfloxacinOfloxacin is a bactericidal drug. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Ofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.Pharmacokinets of OfloxacinAbsorption: Ofloxacin is rapidly and completely absorbed after oral administration.
Distribution: It is widely distributed in the body.
Metabolism: It undergoes insignificant metabolism.
Excretion: Drug is excreted mainly through urine.
Onset of Action for OfloxacinWith in 0.5 hour Duration of Action for Ofloxacin12 - 16 hoursHalf Life of Ofloxacin5 - 8 hoursSide Effects of Ofloxacin1. Nausea
4. Abdominal discomfort
6. Dry mouth
11. Pseudomembranous colitis
12. Visual disturbances
Contra-indications of Ofloxacin1. Hypersensitivity to Ofloxacin and other FluoroquinolonesSpecial Precautions while taking Ofloxacin1. Hepatic impairment
2. Renal impairment
3. Cerebral arteriosclerosis
5. CNS disease
6. Avoid exposure to sunlight
7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Ofloxacin1. Bronchitis
3. Urinary tract infection
4. Bone and joint infections
5. Intra-abdominal infections
7. ENT infections
8. Skin and soft tissue infections
9. Typhoid fever
12. Gynaecological infections
16. CervicitisInteractions for OfloxacinOral Anticoagulants: The effects of oral anticoagulants, may be increased.
Theophylline: Increased plasma levels of theophylline resulting in toxicity.
NSAID`s: CNS excitation may occur.Typical Dosage for OfloxacinAdults: 200 - 400 mg / day depending on the severity and type of infection
Bronchitis, Pneumonia, Skin and soft tissue infections: 800 mg / day in 2 divided doses for 10 days
Gonorrhoea: 400 mg as a single dose.
Prostatis, Cervicitis & Urethritis: 600 mg / day in 2 divided doses for 1 week.
UTI: 200 - 800 mg / day in single or divided doses
Typhoid fever: 400 - 800 mg / day in 2 divided doses
Schedule of OfloxacinHStorage Requirements for OfloxacinStore at 15 - 30 degree C in a tightly closed container.Effects of Missed Dosage of OfloxacinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Effects of Overdose of OfloxacinGive supportive measures and symptomatic treatment. Gastric lavage has to be done.
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