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Ornidazole + Cefixime Pharmacology
Ornidazole + CefiximeAbout Ornidazole + CefiximeN/AMechanism of Action of Ornidazole + CefiximeN/APharmacokinets of Ornidazole + CefiximeN/AOnset of Action for Ornidazole + CefiximeN/ADuration of Action for Ornidazole + CefiximeN/AHalf Life of Ornidazole + CefiximeN/ASide Effects of Ornidazole + CefiximeN/AContra-indications of Ornidazole + CefiximeN/ASpecial Precautions while taking Ornidazole + CefiximeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Ornidazole + CefiximeN/AInteractions for Ornidazole + CefiximeN/ATypical Dosage for Ornidazole + CefiximeN/ASchedule of Ornidazole + CefiximeN/AStorage Requirements for Ornidazole + CefiximeN/AEffects of Missed Dosage of Ornidazole + CefiximeN/AEffects of Overdose of Ornidazole + CefiximeN/A
OrnidazoleAbout OrnidazoleA nitro imidazole derivative, Antiprotozoal antibiotic,Antimicrobial.Mechanism of Action of OrnidazoleOrnidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves 1. Drug enters the cell by diffusion, 2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules. 3. DNA helix destabilization &strand breakage has been observed.
Pharmacokinets of OrnidazoleAbsorption: Well absorbed orally, Distribution: Widely distributed,
Metabolism: Metabolized in liver by conjugation, Excretion: Excreted in urine and small portion is excreted in bile
Onset of Action for OrnidazoleWithin 2 hoursDuration of Action for Ornidazole14hoursHalf Life of Ornidazole12 to 14 hoursSide Effects of Ornidazole1.Abdominal pain
12.VertigoContra-indications of Ornidazole1.Hypersensitivity to the drug or other imidazolesSpecial Precautions while taking Ornidazole1.Vertigo
Pregnancy Related InformationUse with caution
First trimester: contra indicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationMay be usedChildren Related InformationUse with cautionIndications for Ornidazole1.Amoebiasis
4.Anaerobic bacterial infections
Interactions for OrnidazoleN/ATypical Dosage for OrnidazoleAmoebiasis:
Adults: 1gm daily in 2 divided doses for 7 to 10 days
Children: 10 to 25mg/kg once daily for 3days
Adults: 1.5gm once daily for 3 days
Children: 40mg/kg once daily for 3 days
Adults: 1.5gm single daily dose or 0.5gm 12hourly for 5 days,
Male partner should be concurrently treated.
Children: 25mg/kg as a single dose
Adults: 1 to 1.5gm once daily for 2days
Children: 40mg/kg for 2days
Bacterial vaginosis: 1.5gm once or 500mg once daily for 5 to7 days
Schedule of OrnidazoleHStorage Requirements for OrnidazoleStore at cool dry place. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of OrnidazoleTake the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of OrnidazoleTreatment is supportive & symptomatic. Drug is removed by induced emesis, gastric lavage, and administration of activated charcoal &use of cathartics.
CefiximeAbout CefiximeThird Generation Cephalosporin Oral antibioticMechanism of Action of CefiximeCefixime is an orally active 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefixime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefixime. It is highly active against enterobacteriaceae, Haemophilus influenzae, Streptococcus pyogens & Streptococcus pneumonia &many beta lactamase producing bacteria.Pharmacokinets of CefiximeAbsorption: Absorbed orally up to 50 % & food delays absorption Distribution: widely distributed, Metabolism: A portion of drug is metabolized in the body. Excretion: Excreted mainly through urineOnset of Action for CefiximeWithin one hourDuration of Action for Cefixime18 hoursHalf Life of Cefixime3 hourSide Effects of Cefixime1. Diarrhea & stool changes
2. Rashes & allergic manifestation
5. Pseudo membranous colitis
8. Elevated liver enzymes
Contra-indications of Cefixime1.Hypersensitivity to cephalosporins
2.Along with carbamazepine
3.Pseudo membranous colitis
Special Precautions while taking Cefixime1.Renal impairment
2.Patient allergic to penicillins
3.Use cautiously along with salicylates & Probenecid
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationAbove 6 months: may be used
Neonates: contraindicatedIndications for Cefixime1.Tonsillitis
5.Urinary tract infections
7.Infections caused by susceptible organisms.
Interactions for CefiximeProbenecid: Increases and prolongs the effect.
Oral anticoagulants: Effects of anticoagulants potentiated.Typical Dosage for CefiximeAdults: 200 to 400mg once daily or two divided doses
Children: 8mg/kg/day once daily or two divided doses.
Schedule of CefiximeHStorage Requirements for CefiximeN/AEffects of Missed Dosage of CefiximeTake the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.Effects of Overdose of CefiximeAdopting supportive measures. Treatment includes removal of drug from the body by gastric lavage &dialysis
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