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- Pharmacology For Loperamide + Simethicone
Loperamide + Simethicone Pharmacology
Loperamide + SimethiconeAbout Loperamide + SimethiconeN/AMechanism of Action of Loperamide + SimethiconeN/APharmacokinets of Loperamide + SimethiconeN/AOnset of Action for Loperamide + SimethiconeN/ADuration of Action for Loperamide + SimethiconeN/AHalf Life of Loperamide + SimethiconeN/ASide Effects of Loperamide + SimethiconeN/AContra-indications of Loperamide + SimethiconeN/ASpecial Precautions while taking Loperamide + SimethiconeN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Loperamide + SimethiconeN/AInteractions for Loperamide + SimethiconeN/ATypical Dosage for Loperamide + SimethiconeN/ASchedule of Loperamide + SimethiconeN/AStorage Requirements for Loperamide + SimethiconeN/AEffects of Missed Dosage of Loperamide + SimethiconeN/AEffects of Overdose of Loperamide + SimethiconeN/A
LoperamideAbout LoperamideA synthetic piperidine derivative, Opioid, Antidiarrhoeal, Analgesic.Mechanism of Action of LoperamideLoperamide is a mu receptor agonist. It inhibits the release of Acetylcholine on myenteric plexus in the gastrointestinal tract. This results in slowing intestinal motility and reduces peristalsis and increase intestinal transit time. This will results in increased absorption of water from fecal matter. Loperamide also has a direct action on intestinal smooth muscle. It does not have any effect on central nervous system.Pharmacokinets of LoperamideAbsorption: Loperamide is poorly absorbed after oral administration
Distribution: It is widely distributed mainly in protein bound form
Metabolism: Absorbed drug undergoes metabolism in the liver
Excretion: It is excreted mainly in the faeces and small amount in the urine.
Onset of Action for Loperamide1 - 2 hours.Duration of Action for Loperamide1 dayHalf Life of Loperamide7 - 14 hoursSide Effects of Loperamide1.Dry mouth
Contra-indications of Loperamide1.Hypersensitivity to Loperamide
2.Severe diarrhoea where inhibition of peristalsis is not desirable
4.Bloody stool diarrhoea
Special Precautions while taking Loperamide1.Hepatic impairment
2.Acute ulcerative colitis
6.Urinary bladder neck obstruction
8.Use caution while driving vehicle or operating machine or performing activities requiring mental alertness
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationBelow 2 years: contraindicated
Indications for Loperamide1.DiarrhoeaInteractions for LoperamideN/ATypical Dosage for LoperamideAdult (Oral): Initial dose: 4 mg followed by 2 mg after each loose motion. Maintenance dose: 6 - 8 mg daily
Maximum dose: 16 mg / day
2 - 5 years: 3 mg / day in 3 divided doses
6 - 8 years: 4 mg / day in 2 divided doses
8 - 12 years: 6 mg / day in 3 divided doses
Schedule of LoperamideHStorage Requirements for LoperamideStore the drug at 15 - 30 degree C in a tightly closed container. Protect from heat and light.Effects of Missed Dosage of LoperamideDo not apply if it is taken as to control diarrhoea.
If it is taken as a regular schedule then take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of LoperamideGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of activated charcoal. Respiratory depression can be treated with Naloxone.
SimethiconeAbout SimethiconeOral anti-foaming agent, Silicones, Antiflatulent.Mechanism of Action of SimethiconeThis anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.Pharmacokinets of SimethiconeExcretion- Excreted through feces.Onset of Action for SimethiconeN/ADuration of Action for SimethiconeN/AHalf Life of SimethiconeN/ASide Effects of Simethicone1. Bloating
Contra-indications of Simethicone1. Hypersensitivity to the drug
2. Liver disease
3. Kidney disease
4. Serious illness
Special Precautions while taking Simethicone1.Swallow the tablets and capsules with a full glass of water.
2.Chew the chewable tablets thoroughly before swallowing.
3.Shake the drops well before using them.
4.To make administration easier, the drops can be mixed with 30 ml (2 tablespoons) of water or another liquid.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Simethicone1. Abdominal pain which is due to excessive gas in the digestive tract
2. Before gastroscopy or radiography of the bowel
Interactions for SimethiconeN/ATypical Dosage for SimethiconeOral-
Adults and teenagers-
60 -125mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -125 mg four times a day, after meals and at bedtime or 150 mg three times a day, after meals. Not more than 500 mg should be taken in twenty-four hours.
Adults and teenagers-
40 -95 mg four times a day, after meals and at bedtime. Not more than 500 mg should be taken in twenty-four hours.
Schedule of SimethiconeN/AStorage Requirements for SimethiconeStored at room temperature (15-30?C) away from moisture and heat.Effects of Missed Dosage of SimethiconeTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of SimethiconeGive symptomatic and supportive treatment.
Home Delivery for Loperamide + Simethicone in Your City
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Loperamide + Simethicone is a generic medicine name and there are several brands available for it. Some of the brands for loperamide + simethicone might be better known than loperamide + simethicone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have loperamide + simethicone in stock, you can ask for one of the branded alternatives for loperamide + simethicone.