Silymarin Pharmacology


About Silymarin
A polyphenolic flavonoid, Hepatoprotective(antihepatotoxic),antioxidant.
Mechanism of Action of Silymarin
Silymarin stimulates RNA polymerase A and results in an increase in ribosomal protein synthesis and leads to the synthesis of new hepatocytes and also increase the regenerative ability of the liver.
It stabilizes the hepatic cell membrane and prevents the penetration of toxin in to the cell and also slows the absorption of harmful substances in to the liver.
Silymarin contains antioxidant flavanoid. It combines with free radicals formed from metabolic process and also from breakdown of toxic substances and neutralizes them. Because of its antioxidant action it has anti-inflammatory property and it is used in ulcerative colitis and in ulcers.
It increases the glutathione content in the liver and intestine and also increases the activity of super oxide dismutase enzymes and is helpful in detoxifying actions of liver.
Pharmacokinets of Silymarin
Absorption: Silymarin is absorbed after oral administration
Distribution: It is mainly distributed or concentrated in the liver.
Metabolism: It is metabolised in the liver and forms Silymarin conjugates
Excretion: Silymarin conjugates are excreted mainly in the bile and only a small amount excreted through urine.
Onset of Action for Silymarin
Duration of Action for Silymarin
Half Life of Silymarin
Side Effects of Silymarin
1. Diarrhoea
2. Abdominal bloating
3. Flatulence
4. Anorexia
5. Nausea
6. Stomach upset
Contra-indications of Silymarin
1. Hypersensitivity to Silymarin
Special Precautions while taking Silymarin
1. Diabetes mellitus
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Silymarin
1. Cirrhosis
2. Hepatitis
3. Drug induced hepatotoxicity
4. High cholesterol
5. Hepatic disorders ( Infective hepatitis A, Chronic active hepatitis, Toxic metabolic hepatic damage, supportive treatment in cirrhosis and alcoholic liver disease)
Interactions for Silymarin
Typical Dosage for Silymarin
Adult: 70 - 140 mg 2 - 3 times daily
Hepatitis, Cholesterol: 140 mg 3 times daily
Children: 5 mg / kg body weight / day in 2 - 3 divided doses
Schedule of Silymarin
Storage Requirements for Silymarin
Store in a cool dark place. Protect from moisture and heat.
Effects of Missed Dosage of Silymarin
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose
Effects of Overdose of Silymarin
Give supportive measures and symptomatic treatment.

Home Delivery for Silymarin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including silymarin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for silymarin and other medicines and health products. Home delivery services for silymarin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take silymarin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for silymarin before they complete the sale. You can get this information while placing the order for silymarin with the pharmacy.

Silymarin is a generic medicine name and there are several brands available for it. Some of the brands for silymarin might be better known than silymarin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have silymarin in stock, you can ask for one of the branded alternatives for silymarin.