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- Pharmacology For L-Ornithine L-Aspartate + Nicotinamide + Vit B1
L-Ornithine L-Aspartate + Nicotinamide + Vit B1 Pharmacology
L-Ornithine L-Aspartate + Nicotinamide + Vit B1
About L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AMechanism of Action of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/APharmacokinets of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AOnset of Action for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/ADuration of Action for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AHalf Life of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/ASide Effects of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AContra-indications of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/ASpecial Precautions while taking L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AInteractions for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/ATypical Dosage for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/ASchedule of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AStorage Requirements for L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AEffects of Missed Dosage of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AEffects of Overdose of L-Ornithine L-Aspartate + Nicotinamide + Vit B1N/AL-Ornithine L-Aspartate
About L-Ornithine L-AspartateA dietary supplement, a Hepatobiliary preparation., In Hepatic dysfunction.Mechanism of Action of L-Ornithine L-AspartateL-Ornithine L-Aspartate is a stable salt of Ornithine and aspartic acid. Ornithine and Aspartate are the substrate in the metabolic conversion of ammonia to urea and glutamate respectively. LOLA increases ammonia detoxification and decreases ammonia level in the blood and useful in patient with hepatic encephalopathy. It is also involved in the Krebs cycle and it is helpful in energy production.Pharmacokinets of L-Ornithine L-AspartateN/AOnset of Action for L-Ornithine L-AspartateN/ADuration of Action for L-Ornithine L-AspartateN/AHalf Life of L-Ornithine L-AspartateN/ASide Effects of L-Ornithine L-Aspartate1.Transient nausea
2.Vomiting
Contra-indications of L-Ornithine L-AspartatePatient with creatinine level more than 3 mg / 100 mlSpecial Precautions while taking L-Ornithine L-AspartateN/APregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for L-Ornithine L-Aspartate1.Acute and chronic hepatitis
2.Cirrhosis of liver
3.Alcoholic liver damage
4.Adjunct to hepatotoxic drugs
5.Hepatocellular insufficiency- stimulus for glutamine synthesis
Interactions for L-Ornithine L-AspartateN/ATypical Dosage for L-Ornithine L-AspartateORAL
Adult: 1 - 2tablets 3 times daily each tablet contain 150 mg of L-Ornithine L-aspartate
Schedule of L-Ornithine L-AspartateN/AStorage Requirements for L-Ornithine L-AspartateStore at room temperatureEffects of Missed Dosage of L-Ornithine L-AspartateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of L-Ornithine L-AspartateGive supportive measures and symptomatic treatment.Nicotinamide
About NicotinamideWater Soluble Vitamin(B complex- vitamin B3), Amide of nicotinic acid.Mechanism of Action of NicotinamideNicotinamide exerts its action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.Pharmacokinets of NicotinamideAbsorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.Onset of Action for NicotinamideN/ADuration of Action for NicotinamideN/AHalf Life of NicotinamideN/ASide Effects of Nicotinamide1.Activation of peptic ulcer
2.Nausea
3.Vomiting
4.Diarrhoea
5.Headache
6.Hypotension
7.Arrhythmias
8.Hepatic impairment
Contra-indications of Nicotinamide1.Hypersensitivity to the drug
2.Hepatic impairment
3.Peptic ulcer
4.Severe hypotension
5.Arterial haemorrhage
Special Precautions while taking Nicotinamide1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Nicotinamide1.Pellagra
2.Niacin deficiency
3.Hartnup disease
Interactions for NicotinamideN/ATypical Dosage for NicotinamidePellagra: 200 to 500mg daily in divided doses.
Prophylactically: 20 to 50mg daily.
Dietary supplement: 10 to 20mg daily
Hartnup disease: 50 to 200mg daily in divided doses.
Schedule of NicotinamideN/AStorage Requirements for NicotinamideStore at controlled room temperature at a range of 15 to 30 degree C.Effects of Missed Dosage of NicotinamideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of NicotinamideProvide supportive measures and symptomatic treatment.Vit B1
About Vit B1
Physiological functions: Thiamine pyrophosphate is a coenzyme and the active form of vitamin B. It functions as coenzyme in decarboxylation of a-keto acid and in Hexose Monophosphate shunt.
Deficiency symptoms: In severe vitamin B1 deficiency beriberi develops. It is of two types:
a) Wet beriberi
b) Dry beriberi
Wet beriberi: In this the symptoms are related to the cardiovascular system and they are palpitations, tachycardia, dyspnoea, ECG changes, oedema, and high output cardiac failure.
Dry beriberi: The symptoms and signs are related to the Nervous system. The main features are peripheral neuritis, hyperaesthesia (localized areas) or anaesthesia, there is gradual loss in muscle strength, wrist drop, poor memory, depression, lack of initiative and anorexia.Mechanism of Action of Vit B1Thiamine exerts it`s action by influencing carbohydrate metabolism. It combines with ATP to form thiamine pyrophosphate in the body. Thiamine pyrophosphate acts as a coenzyme for carbohydrate metabolism, decarboxylation of ketoacids, and hexose monophosphate shunt. It also have plays some role in neuromuscular transmission.Pharmacokinets of Vit B1Absorption: Well absorbed orally.
Distribution: Widely distributed in the body. It is also distributed in to breast milk.
Metabolism: Metabolized in the liver.
Excretion: Excess thiamine is excreted through urine.
Onset of Action for Vit B1N/ADuration of Action for Vit B1N/AHalf Life of Vit B1N/ASide Effects of Vit B11. Angioedema
2. Cardiovascular collapse
3. Cyanosis
4. Restleessness
5. Nausea
6. Haemorrhage
7. Weakness
8. Allergic reactions
9. Tightness of throat
10. Feeling of warmth
11. Urticaria
12. Pruritus
13. Tenderness and induration following I. M. administration
Contra-indications of Vit B11. Hypersensitivity to the drugSpecial Precautions while taking Vit B1N/APregnancy Related InformationUse with cautionOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Vit B11. Thiamine deficiency
2. Dry beriberi
3. Wet beriberi
4. Wernicke`s encephalopathy
5. Hyperemesis gravidarum
6. Korsakoffs syndrome
7. Polyneuritis secondary to alcoholism
8. Multiple neurosis
9. Toxic and confusional states
10. Anorexia nervosa
11. Delirium
Interactions for Vit B1N/ATypical Dosage for Vit B1Oral :
In mild deficiency: 10 to 25mg/day.
In severe deficiency: 200 to 300mg/day.
I.M, I.V.:
Beriberi:
Adults: 10 to 20mg I.M. depending up on the severity of the condition (Up to 100mg I.M. or I.V. for severe cases); thrice daily for two weeks followed by dietary correction and multivitamin supplement containing 5 to 30mg Thiamine/day in single or divided doses for 1 month.
Wernicke`s encephalopathy: 100mg I.V. followed by 50 to 100mg IM. or I.V./day.
"Wet beriberi with heart failure": 10 to 30mg I.V. for emergency treatment.
Schedule of Vit B1C1 (Oral)Storage Requirements for Vit B1Store in a well closed container; in a cool place and protect from light.Effects of Missed Dosage of Vit B1Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vit B1Provide symptomatic treatment and supportive measures.Home Delivery for L-Ornithine L-Aspartate + Nicotinamide + Vit B1 in Your City
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L-Ornithine L-Aspartate + Nicotinamide + Vit B1 is a generic medicine name and there are several brands available for it. Some of the brands for l-ornithine l-aspartate + nicotinamide + vit b1 might be better known than l-ornithine l-aspartate + nicotinamide + vit b1 itself. If the pharmacy that's willing to deliver medicines to your home doesn't have l-ornithine l-aspartate + nicotinamide + vit b1 in stock, you can ask for one of the branded alternatives for l-ornithine l-aspartate + nicotinamide + vit b1.
