Chenodeoxycholic Acid Pharmacology

Chenodeoxycholic Acid

About Chenodeoxycholic Acid
Primary bile acid,1 of the 3 major biliary bile acids,Gallstone Solubilizing Agents, Anticholelithic.
Mechanism of Action of Chenodeoxycholic Acid
Chenodeoxycholic acid is a bile acid. Normally there is a balance between cholesterol and bile acids in the liver. When there is an excess in cholesterol level, cholesterols are separated out from bile and form stones. Chenodeoxycholic acid is a bile acid itself, it increase the level of bile acids within the bile. It increases the secretion of bile acids. It also reduces the synthesis and release of cholesterol from liver and also reduces the absorption of cholesterol from the gut. All these reverse the imbalance and prevent the separation of cholesterol from the bile acids and the bile acids also help to dissolve gall stones.
Pharmacokinets of Chenodeoxycholic Acid
Absorption: Chenodeoxycholic acid is incompletely absorbed after oral administration. Absorbed drugs undergo hepatic extraction.
Distribution: It is mainly concentrated in the liver and undergoes enterohepatic circulation.
Metabolism: In the liver it undergoes conjugation with glycine or taurine.
Excretion: It is excreted mainly in the bile.
Onset of Action for Chenodeoxycholic Acid
Within 30 minutes
Duration of Action for Chenodeoxycholic Acid
12 hours
Half Life of Chenodeoxycholic Acid
Side Effects of Chenodeoxycholic Acid
3.Abdominal cramps
Contra-indications of Chenodeoxycholic Acid
1.Hypersensitivity to Ursodeoxycholic acid
2.Radio opaque gall stones
3.Ulcerative colitis
4.Peptic ulcer
5.Non emptying gall bladder
8.Hepatic impairment
10.Crohn`s disease
Special Precautions while taking Chenodeoxycholic Acid
1.Hepatic encephalopathy
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
NEONATES: contraindicated
Indications for Chenodeoxycholic Acid
1.Gall stone disease
Interactions for Chenodeoxycholic Acid
Cholestryamine, colestipol & aluminium antacids: Reduce the efficacy of chenodeoxycholic acid.
Oral contraceptives: Oestrogen preparations may reduce the efficacy of chenodeoxycholic acid.
Typical Dosage for Chenodeoxycholic Acid
Adult: 10 - 15 mg / kg body weight / day in 2 divided doses for 2 years depending on the size of the stone. Continue the treatment 3 - 4 more months after dissolution of gall stones
Children: not recommended
Schedule of Chenodeoxycholic Acid
Storage Requirements for Chenodeoxycholic Acid
Store at 20-25 degree C in a tightly closed container. Protect from direct light and moisture. Keep out of the reach of children
Effects of Missed Dosage of Chenodeoxycholic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chenodeoxycholic Acid
Give supportive measures and symptomatic treatment.

Home Delivery for Chenodeoxycholic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chenodeoxycholic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chenodeoxycholic acid and other medicines and health products. Home delivery services for chenodeoxycholic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take chenodeoxycholic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chenodeoxycholic acid before they complete the sale. You can get this information while placing the order for chenodeoxycholic acid with the pharmacy.

Chenodeoxycholic Acid is a generic medicine name and there are several brands available for it. Some of the brands for chenodeoxycholic acid might be better known than chenodeoxycholic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chenodeoxycholic acid in stock, you can ask for one of the branded alternatives for chenodeoxycholic acid.