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- Pharmacology For Chenodeoxycholic Acid
Chenodeoxycholic Acid Pharmacology
Chenodeoxycholic AcidAbout Chenodeoxycholic AcidPrimary bile acid,1 of the 3 major biliary bile acids,Gallstone Solubilizing Agents, Anticholelithic.Mechanism of Action of Chenodeoxycholic AcidChenodeoxycholic acid is a bile acid. Normally there is a balance between cholesterol and bile acids in the liver. When there is an excess in cholesterol level, cholesterols are separated out from bile and form stones. Chenodeoxycholic acid is a bile acid itself, it increase the level of bile acids within the bile. It increases the secretion of bile acids. It also reduces the synthesis and release of cholesterol from liver and also reduces the absorption of cholesterol from the gut. All these reverse the imbalance and prevent the separation of cholesterol from the bile acids and the bile acids also help to dissolve gall stones.Pharmacokinets of Chenodeoxycholic AcidAbsorption: Chenodeoxycholic acid is incompletely absorbed after oral administration. Absorbed drugs undergo hepatic extraction.
Distribution: It is mainly concentrated in the liver and undergoes enterohepatic circulation.
Metabolism: In the liver it undergoes conjugation with glycine or taurine.
Excretion: It is excreted mainly in the bile.
Onset of Action for Chenodeoxycholic AcidWithin 30 minutesDuration of Action for Chenodeoxycholic Acid12 hoursHalf Life of Chenodeoxycholic AcidN/ASide Effects of Chenodeoxycholic Acid1.Nausea
Contra-indications of Chenodeoxycholic Acid1.Hypersensitivity to Ursodeoxycholic acid
2.Radio opaque gall stones
5.Non emptying gall bladder
10.Crohn`s diseaseSpecial Precautions while taking Chenodeoxycholic Acid1.Hepatic encephalopathyPregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationContraindicated.Children Related InformationContraindicated.
NEONATES: contraindicatedIndications for Chenodeoxycholic Acid1.Gall stone diseaseInteractions for Chenodeoxycholic AcidCholestryamine, colestipol & aluminium antacids: Reduce the efficacy of chenodeoxycholic acid.
Oral contraceptives: Oestrogen preparations may reduce the efficacy of chenodeoxycholic acid.Typical Dosage for Chenodeoxycholic AcidAdult: 10 - 15 mg / kg body weight / day in 2 divided doses for 2 years depending on the size of the stone. Continue the treatment 3 - 4 more months after dissolution of gall stones
Children: not recommended
Schedule of Chenodeoxycholic AcidN/AStorage Requirements for Chenodeoxycholic AcidStore at 20-25 degree C in a tightly closed container. Protect from direct light and moisture. Keep out of the reach of childrenEffects of Missed Dosage of Chenodeoxycholic AcidTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chenodeoxycholic AcidGive supportive measures and symptomatic treatment.
Home Delivery for Chenodeoxycholic Acid in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chenodeoxycholic acid.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chenodeoxycholic acid and other medicines and health products. Home delivery services for chenodeoxycholic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take chenodeoxycholic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chenodeoxycholic acid before they complete the sale. You can get this information while placing the order for chenodeoxycholic acid with the pharmacy.
Chenodeoxycholic Acid is a generic medicine name and there are several brands available for it. Some of the brands for chenodeoxycholic acid might be better known than chenodeoxycholic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chenodeoxycholic acid in stock, you can ask for one of the branded alternatives for chenodeoxycholic acid.