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- Pharmacology For Lignocaine + Prilocaine
Lignocaine + Prilocaine Pharmacology
Lignocaine + PrilocaineAbout Lignocaine + PrilocaineN/AMechanism of Action of Lignocaine + PrilocaineN/APharmacokinets of Lignocaine + PrilocaineN/AOnset of Action for Lignocaine + PrilocaineN/ADuration of Action for Lignocaine + PrilocaineN/AHalf Life of Lignocaine + PrilocaineN/ASide Effects of Lignocaine + PrilocaineN/AContra-indications of Lignocaine + PrilocaineN/ASpecial Precautions while taking Lignocaine + PrilocaineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Lignocaine + PrilocaineN/AInteractions for Lignocaine + PrilocaineN/ATypical Dosage for Lignocaine + PrilocaineN/ASchedule of Lignocaine + PrilocaineN/AStorage Requirements for Lignocaine + PrilocaineN/AEffects of Missed Dosage of Lignocaine + PrilocaineN/AEffects of Overdose of Lignocaine + PrilocaineN/A
LignocaineAbout LignocaineLincosamide antibiotic , Antibiotic.Mechanism of Action of LignocaineN/APharmacokinets of LignocaineN/AOnset of Action for LignocaineN/ADuration of Action for LignocaineN/AHalf Life of LignocaineN/ASide Effects of LignocaineN/AContra-indications of LignocaineN/ASpecial Precautions while taking LignocaineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for LignocaineN/AInteractions for LignocaineN/ATypical Dosage for LignocaineN/ASchedule of LignocaineN/AStorage Requirements for LignocaineN/AEffects of Missed Dosage of LignocaineN/AEffects of Overdose of LignocaineN/A
PrilocaineAbout PrilocaineAmino amide derivative, Local Anesthetic.Mechanism of Action of PrilocainePrilocaine is an amide type local anaesthetic. It exerts its action by interacting with a receptor situated within the voltage sensitive Na+ channels and raises the threshold of channel opening. It blocks nerve conductions by decreasing the entry of sodium ions during upstroke of action potential. The rate of rise of action potential and maximum depolarization decreases in a concentration dependent manner and causing slowing of conduction and finally local depolarization fails to reach the threshold potential and conduction block ensures. Na+ permeability fails to increase in response to an impulse or stimulus. Thus the drug exerts its local anesthetic action by membrane stabilizing effect.
Surface anaesthesia: Cream containing Lidocaine 2.5% and Prilocaine 2.5% as a eutectic mixture produce local anaesthesia when applied topically to intact skin. It is useful in venepuncture, extracorporeal shock, retrobulbar injections, lumbar puncture, genital wart removal, laser treatment, intravenous or arterial cannulation, split skin grafting, and circumcision.
Pharmacokinets of PrilocaineAbsorption: It is completely absorbed after parenteral administration. Distribution: About 55% of the drug is distributed in protein bound form. Metabolism: It undergoes metabolism in the liver and also in the kidney. Excretion: Drug and its metabolites are excreted mainly in urineOnset of Action for Prilocaine1 - 2 minuteDuration of Action for Prilocaine60minuteHalf Life of PrilocaineN/ASide Effects of Prilocaine1. Drowsiness
3. Blurred vision
10. Cardiac depression
13. Ventricular fibrillation
14. Cardiac arrest
15. Respiratory arrest
Contra-indications of Prilocaine1. Hypersensitivity to the drug
2. AV block
3. SA block
4. Intra ventricular block
5. Cardiac decompensation
6. Supra ventricular arrhythmia
7. Conduction disturbances
8. Strokes Adams Syndrome
9. Wolff Parkinson White syndrome
10. Infection or inflammation in puncture region
12. Severe hypertension
13. Spinal deformities
14. Neurological disorders
Special Precautions while taking Prilocaine1. Hepatic impairment
2. Renal impairment
3. Deliberate individuals
4. Complete or second degree heart block
5. Sinus Bradycardia
6. Heart failure
9. Malignant hyperthermia
10. Monitor ECG with caution during therapy
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Prilocaine1.Nerve block
Interactions for PrilocaineN/ATypical Dosage for PrilocaineDental infiltration: 40 to 80 mg (1 to 2 ml) as a 4% solution;
Children (above 6 month of age):5 mg / kg body weight
Adult: Apply the cream under an occlusive dressing for 60 minutes
Removal of genital warts: Apply for 5 - 10 minutes without occlusive dressing
Children: Apply the cream under an occlusive dressing for 30 minutes
Schedule of PrilocaineN/AStorage Requirements for PrilocaineStore below 25degree C. Keep out of reach of children.Effects of Missed Dosage of PrilocaineApply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PrilocaineGive supportive measures and symptomatic treatment.
Home Delivery for Lignocaine + Prilocaine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lignocaine + prilocaine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lignocaine + prilocaine and other medicines and health products. Home delivery services for lignocaine + prilocaine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take lignocaine + prilocaine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lignocaine + prilocaine before they complete the sale. You can get this information while placing the order for lignocaine + prilocaine with the pharmacy.
Lignocaine + Prilocaine is a generic medicine name and there are several brands available for it. Some of the brands for lignocaine + prilocaine might be better known than lignocaine + prilocaine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lignocaine + prilocaine in stock, you can ask for one of the branded alternatives for lignocaine + prilocaine.