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- Pharmacology For Lignocaine+Calcium dobesilate
Lignocaine+Calcium dobesilate Pharmacology
Lignocaine+Calcium dobesilateAbout Lignocaine+Calcium dobesilateN/AMechanism of Action of Lignocaine+Calcium dobesilateN/APharmacokinets of Lignocaine+Calcium dobesilateN/AOnset of Action for Lignocaine+Calcium dobesilateN/ADuration of Action for Lignocaine+Calcium dobesilateN/AHalf Life of Lignocaine+Calcium dobesilateN/ASide Effects of Lignocaine+Calcium dobesilateN/AContra-indications of Lignocaine+Calcium dobesilateN/ASpecial Precautions while taking Lignocaine+Calcium dobesilateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Lignocaine+Calcium dobesilateN/AInteractions for Lignocaine+Calcium dobesilateN/ATypical Dosage for Lignocaine+Calcium dobesilateN/ASchedule of Lignocaine+Calcium dobesilateN/AStorage Requirements for Lignocaine+Calcium dobesilateN/AEffects of Missed Dosage of Lignocaine+Calcium dobesilateN/AEffects of Overdose of Lignocaine+Calcium dobesilateN/A
LignocaineAbout LignocaineLincosamide antibiotic , Antibiotic.Mechanism of Action of LignocaineN/APharmacokinets of LignocaineN/AOnset of Action for LignocaineN/ADuration of Action for LignocaineN/AHalf Life of LignocaineN/ASide Effects of LignocaineN/AContra-indications of LignocaineN/ASpecial Precautions while taking LignocaineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for LignocaineN/AInteractions for LignocaineN/ATypical Dosage for LignocaineN/ASchedule of LignocaineN/AStorage Requirements for LignocaineN/AEffects of Missed Dosage of LignocaineN/AEffects of Overdose of LignocaineN/A
Calcium DobesilateAbout Calcium DobesilateAntithrombotic, vasoprotective.Mechanism of Action of Calcium DobesilateIt acts on capillary and venous walls and decreases increased capillary and venous permeability and fragility and improves decreased resistance. Thus exerting an anti edematous and protective action on blood vessels. It increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase. It acts on endothelial layer and basement membrane of capillaries and decreases histamine and bradykinin induced hyperpermeability. It prevents breakdown of collagen and reduce viscosity of blood and plasma and improves blood flow & prevents stasis but accelerates type-2 collagen fibrinogenesis a major structural component of arterial wall. It exerts antiplatelet and fibrinolytic actions by inhibiting platelet activation factor and enhancing the release of tissue plasminogen activator & hence improves blood flow to tissues. It decreases platelet aggregation stimulated by collagen and thrombin and antiplatelet action counteract thrombosis. It inhibits two pathophysiological reactions in diabetes viz. polyol pathway and glycation of proteins by inhibitory effects on aldose reductase. It also inhibits formation of sorbitol.Pharmacokinets of Calcium DobesilateAbsorption: Well absorbed orally
Distribution: Widely distributed in to the body
Metabolism: A portion is metabolized in kidneys
Excretion: Excreted through urine and faeces
Onset of Action for Calcium DobesilateN/ADuration of Action for Calcium DobesilateN/AHalf Life of Calcium Dobesilate2 to 8hoursSide Effects of Calcium Dobesilate1.Gastro intestinal irritation
Contra-indications of Calcium Dobesilate1.Hypersensitivity to the drugSpecial Precautions while taking Calcium Dobesilate1.Renal impairment
5.Allergic manifestations such as rashes, Pruritus, fever etc.
Pregnancy Related InformationMay be used
First trimester: contraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Calcium Dobesilate1.Diabetic retinopathy
Interactions for Calcium DobesilateN/ATypical Dosage for Calcium DobesilateDiabetic retinopathy and micro angiopathy:
500mg to1000mg/day in two divided doses for 4 to 6months followed by 500mg once daily.
Varicose veins and Haemorrhoids:
500mg 12th hourly up to 3 weeks followed by 500mg once daily
Prevention of secondary myocardial infarction:
Schedule of Calcium DobesilateHStorage Requirements for Calcium DobesilateStore in well closed container and protected from light and moisture. Keep out of reach of childrenEffects of Missed Dosage of Calcium DobesilateTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Calcium DobesilateTreatment is supportive and symptomatic. Perform induced emesis and gastric lavage.
Home Delivery for Lignocaine+Calcium dobesilate in Your City
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Lignocaine+Calcium dobesilate is a generic medicine name and there are several brands available for it. Some of the brands for lignocaine+calcium dobesilate might be better known than lignocaine+calcium dobesilate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lignocaine+calcium dobesilate in stock, you can ask for one of the branded alternatives for lignocaine+calcium dobesilate.