Polidocanol Pharmacology


About Polidocanol
A sclerosant, Antivaricose therapy.
Mechanism of Action of Polidocanol
It is a long chain fatty alcohol which exerts its action by acting as a sclerosing agent. It produce haemostasis by it`s spasmogenic effect and by irritant action early oedema with subsequent inflammation and thrombosis of the vessel.
Pharmacokinets of Polidocanol
Absorption: Administered parenterally Distribution: Widely distributed.
Onset of Action for Polidocanol
Duration of Action for Polidocanol
Half Life of Polidocanol
4 hours
Side Effects of Polidocanol
1.Allergic manifestations
2.Decreased heart rate
3.Local necrosis
4.Phlebitis at bleeding from injection site
7.Pulmonary edema

Contra-indications of Polidocanol
1.Hypersensitivity to the drug
2.Intra- arterial application
3.History of recent thrombosis
4.Third and fourth degree arterial occlusive diseases
5.Damage to deep veins
6.Bed-ridden patients
7.Acute inflammation in anal region
Special Precautions while taking Polidocanol
1.Diabetes mellitus
2.Cardiovascular disorders
3.Diseases associated with restricted freedom of movement
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Polidocanol
1.Bleeding oesophageal varices
2.Bleeding gastro duodenal ulcers
3.Superficial venules and telangiectasias
4. Varicose veins
Interactions for Polidocanol
Typical Dosage for Polidocanol
Smallest varices: 0.5 to 1% solution
Medium sized varices: 1 to 2% solution
Large varices: 3 to 5% solution
Starts with a rather weak solution and inject 0.2 to 0.5ml intravenously. Increases the concentration if required. In case of largest varices up to 2ml is required
Maximum dose: 2mg/kg/day
0.5 to 1.5ml drug 3% or 5%/node as submucous injection.
A maximum of 2ml during 1st session and 3ml during subsequent sessions should be administered. In case of external Haemorrhoids administer subcutaneously to pedicle.
4 to 8 sessions during monthly intervals are required.

Schedule of Polidocanol
Storage Requirements for Polidocanol
Store below 25 degree C. and protect from light
Effects of Missed Dosage of Polidocanol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.
Effects of Overdose of Polidocanol
Depending up on the quantity of drug injected; Procaine 1% (0.5 to 2ml) or physiological common salt solution (5 to 20ml) should be injected at the same site, if possible in conjunction with hyaluronidase.

Home Delivery for Polidocanol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including polidocanol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for polidocanol and other medicines and health products. Home delivery services for polidocanol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take polidocanol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for polidocanol before they complete the sale. You can get this information while placing the order for polidocanol with the pharmacy.

Polidocanol is a generic medicine name and there are several brands available for it. Some of the brands for polidocanol might be better known than polidocanol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have polidocanol in stock, you can ask for one of the branded alternatives for polidocanol.