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- Pharmacology For Dextropropoxyphene + Ibuprofen
Dextropropoxyphene + Ibuprofen Pharmacology
Dextropropoxyphene + IbuprofenAbout Dextropropoxyphene + IbuprofenN/AMechanism of Action of Dextropropoxyphene + IbuprofenN/APharmacokinets of Dextropropoxyphene + IbuprofenN/AOnset of Action for Dextropropoxyphene + IbuprofenN/ADuration of Action for Dextropropoxyphene + IbuprofenN/AHalf Life of Dextropropoxyphene + IbuprofenN/ASide Effects of Dextropropoxyphene + IbuprofenN/AContra-indications of Dextropropoxyphene + IbuprofenN/ASpecial Precautions while taking Dextropropoxyphene + IbuprofenN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextropropoxyphene + IbuprofenN/AInteractions for Dextropropoxyphene + IbuprofenN/ATypical Dosage for Dextropropoxyphene + IbuprofenN/ASchedule of Dextropropoxyphene + IbuprofenN/AStorage Requirements for Dextropropoxyphene + IbuprofenN/AEffects of Missed Dosage of Dextropropoxyphene + IbuprofenN/AEffects of Overdose of Dextropropoxyphene + IbuprofenN/A
DextropropoxypheneAbout DextropropoxypheneA synthetic morphine derivative,Opioid-like agonist,optical isomer of Levopropoxyphene, Narcotic Analgesic, anti-tussive and local anesthetic.Mechanism of Action of DextropropoxypheneIt acts on the CNS Opioid receptors. It has agonist action on mu Opioid receptors. It primarily binds to the mu Opioid receptors and produce analgesia. Its CNS effects are same as morphine. It gives in combination with other Non Steroidal Anti Inflammatory Drugs or other analgesics usually.
Pharmacokinets of DextropropoxypheneAbsorption-Orally absorbed; primarily to the upper small intestine.
Distribution-Widely distributed in the body. Enters the cerebrospinal fluid and cross the placenta.
Metabolism-In liver it is metabolized by N-demethylation. Norpropoxyphene is its active metabolite. It has more half life than parent drug. It causes toxicity at sometime due to its metabolites accumulation in the body.
Excretion-It is excreted through urine.
Onset of Action for Dextropropoxyphene30 to 60 min. after oral administrationDuration of Action for Dextropropoxyphene4 to 6 hrsHalf Life of DextropropoxyphenePlasma half life is 6 to 12 hrsSide Effects of Dextropropoxyphene1. Nausea
3. Epigastric distress
7. Visual disturbances
8. Physiological dependence
Contra-indications of Dextropropoxyphene1. Hypersensitivity to this drug
2. Respiratory depression
3. Children below 12 years
Special Precautions while taking Dextropropoxyphene1. In patients with hepatic failure or renal failure used cautiously
2. Patient can not drive or operate machinery after the drug administration. So the care should be taken
3. Use cautiously in patients with suicidal mentality
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationN/AIndications for Dextropropoxyphene1. Relieve moderate to severe pain in various conditions
2. Opioid withdrawal
Interactions for DextropropoxypheneBarbiturate anaesthetics: May increase respiratory and CNS depressive effects of propoxyphene.
Warfarin: Potentiation of hypoprothrombinemic effect.
Carbamazipine: May increase serum carbamzipine levels with resultant toxicity.Typical Dosage for DextropropoxypheneOral-
Adults - 65mg 3 to 4 times daily.
Schedule of DextropropoxypheneHStorage Requirements for DextropropoxypheneStore controlled room temperature i.e. between 15 and 30 degree CelsiusEffects of Missed Dosage of DextropropoxypheneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextropropoxypheneProvide supportive and symptomatic treatment. Establish artificial respiratory exchange. In the case of respiratory or cardiovascular depression administer a narcotic antagonist i.e. naloxone.Induce emesis or gastric lavage if the patient shows symptoms within 2hrs after drug administration. Avoid the risk of aspiration. For the further removal of drug, administer activated charcoal via nasogastric tube. Continue the supportive treatment and closely monitor the laboratory parameters, vital signs, neurological status closely. In some cases dialysis may be helpful for the treatment.
IbuprofenAbout IbuprofenNSAID, a propionic acid derivative, Analgesic and anti-inflammatory.Mechanism of Action of IbuprofenIbuprofen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Ibuprofen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions. It also inhibits platelet aggregation and prolongs bleeding time.Pharmacokinets of IbuprofenAbsorption: Ibuprofen is rapidly absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Ibuprofen and its metabolites are excreted mainly in the urine and some amount in bile.Onset of Action for Ibuprofen? hoursDuration of Action for Ibuprofen4-6 hours.Half Life of Ibuprofen2 hoursSide Effects of Ibuprofen1.Nausea
11.Blurring of vision
Contra-indications of Ibuprofen1.Hypersensitivity to Ibuprofen and other NSAIDs
Special Precautions while taking Ibuprofen1.Hepatic impairment
5.Pre existing asthma
Pregnancy Related InformationUse with caution
PREGNANCY in third trimester: contraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
CHILDREN below 6 months: contraindicatedIndications for Ibuprofen1.Rheumatoid arthritis
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
6.For the relief of fever, pain and inflammation in dental, minor surgery and orthopedic
10.Patent ductus arteriosus(IV)
Interactions for IbuprofenN/ATypical Dosage for IbuprofenAdult: 1.2 g / day in3 divided doses
Arthritis, gout and dental pain: 300 - 800 mg 3 times daily dose can be increased if needed.
Maximum dose: 3200 mg / day
Pain, Dysmenorrhoea: 1600 - 2400 mg / day in 4 - 6 divided doses
Fever: 600 mg / day in 3 divided doses.
Maximum dose: 1200 mg / day
For migraine: 400 -800 mg 3 times daily
Children: 15- 20 mg / kg body weight / day in 3 - 4 divided doses
Maximum dose: 40 mg / kg body weight / day
Schedule of IbuprofenHStorage Requirements for IbuprofenStore Ibuprofen at 15-30 degree C in a tightly closed light resistant container.Effects of Missed Dosage of IbuprofenTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of IbuprofenGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Excretion of the drug can be enhanced by administration of alkaline diuretics.
Home Delivery for Dextropropoxyphene + Ibuprofen in Your City
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Dextropropoxyphene + Ibuprofen is a generic medicine name and there are several brands available for it. Some of the brands for dextropropoxyphene + ibuprofen might be better known than dextropropoxyphene + ibuprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextropropoxyphene + ibuprofen in stock, you can ask for one of the branded alternatives for dextropropoxyphene + ibuprofen.