Triamterene Pharmacology

Triamterene

About Triamterene
A potassium-sparing diuretic, Diuretic,Antioedema, Adjunctive in therapy of hypertension.
Mechanism of Action of Triamterene
Triamterene exerts its diuretic action by interacting with renal epithelial Na+ channels in distal tubules and collecting duct and prevent sodium reabsorption. It prevents potassium and magnesium loses. It also increases chloride, bicarbonate, and water excretion. The drug augment the natriuretic and anti hypertensive response of other diuretic drugs. It is used in the management of edema associated with congestive heart failure, hepatic cirrhosis with ascites, nephrotic syndrome, and idiopathic edema. It is used mainly in combination with other drugs in the management of hypertension and to correct hypokalemia caused by other diuretic drugs
Pharmacokinets of Triamterene
Absorption: Rapidly but incompleately absorbed orally, Distribution: It is distributed in a protein bound form, Metabolism: It metabolized in to an active metabolite in the body,
Excretion: Excreted through urine.
Onset of Action for Triamterene
2 to4hours
Duration of Action for Triamterene
12 to 16 hours
Half Life of Triamterene
100 to 150minutes
Side Effects of Triamterene
1.Headache
2.Dizziness
3.Nausea
4.Diarrhoea
5.Vomiting
6.Dry mouth
7.Weakness
8.Hyper kalemia
9.Hyponatremia
10.Thrombocytopenia
11.Agranulocytosis
12.Photosensitivity
13.Reduce glucose tolerance
14.Altered liver function tests
15.Altered kidney function tests
16.Gastro intestinal disturbances
17.Interstitial nephritis
18.Kidney stones
19.Rashes
20.Ototoxicity
Contra-indications of Triamterene
1.Hypersensitivity to the drug
2.Renal impairment
3.Hyper kalemia
4.Along with other potassium sparing diuretics
5.Anuria
6.Hepatic impairment

Special Precautions while taking Triamterene
1.Gout
2.Diabetes mellitus
3.Deliberate individuals

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Triamterene
1.Oedema
2.Liddle`s syndrome
3.Adjunctive in therapy of hypertension

Interactions for Triamterene
Amantadine: Triamterene increases the toxic effects of Amantadine.
ACE inhibitors: May result in significant hyperkalaemia.
Indomethacin: May produce unexpectedly high incidence of nephrotoxicity.
Potassium preparations: May result in hyperkalaemia, possibly with cardiac arrhythmias or cardiac arrest, particularly in those with impaired renal function.
Lab tests: Since both triamterene and quinidine have similar fluorescene spectra, triamterene will interfere with fluoroscent measurement of Quinidine serum levels.
Typical Dosage for Triamterene
100 to 250mg/day in divided doses.
Children: 2mg/kg two times daily. Take after break fast & lunch. Reduce the dosage after one week in to alternate days.
Schedule of Triamterene
H
Storage Requirements for Triamterene
Store at controlled room temperature at a range of 20 to 25 degree C. in a well closed container and protects from light.




Effects of Missed Dosage of Triamterene
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Triamterene
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and support electrolyte balance and blood acidosis. Reduce serum potassium with I.V. sodium bicarbonate or glucose with insulin. Potassium level is also reduced by a cation exchange resins like sodium polystyrene sulfonate given orally or as retention enema.

Home Delivery for Triamterene in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including triamterene.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for triamterene and other medicines and health products. Home delivery services for triamterene may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take triamterene only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for triamterene before they complete the sale. You can get this information while placing the order for triamterene with the pharmacy.

Triamterene is a generic medicine name and there are several brands available for it. Some of the brands for triamterene might be better known than triamterene itself. If the pharmacy that's willing to deliver medicines to your home doesn't have triamterene in stock, you can ask for one of the branded alternatives for triamterene.