Tolterodine Tartarate Pharmacology

Tolterodine Tartarate

About Tolterodine Tartarate
Anticholinergic ( antimuscarinic), Treat urinary incontinence.
Mechanism of Action of Tolterodine Tartarate
Tolterodine tartrate is a specific muscarinic receptor (M3 receptor) antagonist. It blocks muscarinic receptors which can be found on the muscle cells of the bladder wall. It prevents the action of acetyl choline on these receptors. Acetylcholine acting on these receptors causes the muscle in the bladder wall to contract, and the bladder to empty. By preventing this, Tolterodine helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. This in turn reduces the need to pass urine.
Stimulation of muscarinic receptors causes the bladder to contract and empty. Tolterodine relax the involuntary muscle in the wall of the bladder.
Pharmacokinets of Tolterodine Tartarate
Absorption: It is well absorbed after oral administration.
Distribution: Tolterodine tartrate is widely distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver by oxidation to active 5-hydroxy methyl metabolite.
Excretion: it is excreted mainly in the urine and the rest excreted through faeces.
Onset of Action for Tolterodine Tartarate
N/A
Duration of Action for Tolterodine Tartarate
N/A
Half Life of Tolterodine Tartarate
2 - 3.5 hours
Side Effects of Tolterodine Tartarate
1. Headache
2. Abdominal pain
3. Constipation
4. Blurred vision
5. Urinary retention
6. Dry mouth
7. Flatulence
8. Vomiting
9. Drowsiness
10. Confusion
11. Dyspepsia
12. Paresthesia
13. Dryness of the skin and eyes
14. Somnolence
15. Nervousness
16. Dysuria

Contra-indications of Tolterodine Tartarate
1. Hypersensitivity to Tolterodine
2. Urinary retention
3. Gastric retention
4. Ulcerative colitis
5. Crohn`s disease
6. Abnormal muscle weakness
7. Closed angle glaucoma
Special Precautions while taking Tolterodine Tartarate
1. Hepatic impairment
2. Renal impairment
3. Heart failure
4. Bradycardia
5. Ischaemic heart disease
6. Autonomic neuropathy
7. Arrhythmia
8. Intestinal obstruction
9. Hiatus hernia
10. Hypokalaemia
10. Do not drive vehicle, operate machine and other works which require mental alertness

Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Tolterodine Tartarate
1. Urinary frequency
2. Urinary urgency
3. Urinary incontinence
Interactions for Tolterodine Tartarate
Patients receiving cytochrome P450 3A4 inhibitors (erythromycin, ketoconazole, miconazole, etc.) should not receive more than 1mg twice daily.
Typical Dosage for Tolterodine Tartarate
Oral
Adult: Initial dose: 4 mg / day in 2 divided doses based on response and tolerance dose can be reduced to 2 mg / day.
Children: not recommended
Schedule of Tolterodine Tartarate
N/A
Storage Requirements for Tolterodine Tartarate
Store in a cool dark place. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Tolterodine Tartarate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolterodine Tartarate
Give supportive measures and symptomatic treatment.

Home Delivery for Tolterodine Tartarate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolterodine tartarate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolterodine tartarate and other medicines and health products. Home delivery services for tolterodine tartarate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolterodine tartarate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolterodine tartarate before they complete the sale. You can get this information while placing the order for tolterodine tartarate with the pharmacy.

Tolterodine Tartarate is a generic medicine name and there are several brands available for it. Some of the brands for tolterodine tartarate might be better known than tolterodine tartarate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolterodine tartarate in stock, you can ask for one of the branded alternatives for tolterodine tartarate.