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- Pharmacology For Finasteride + Tamsulosin
Finasteride + Tamsulosin Pharmacology
Finasteride + Tamsulosin
About Finasteride + TamsulosinN/AMechanism of Action of Finasteride + TamsulosinN/APharmacokinets of Finasteride + TamsulosinN/AOnset of Action for Finasteride + TamsulosinN/ADuration of Action for Finasteride + TamsulosinN/AHalf Life of Finasteride + TamsulosinN/ASide Effects of Finasteride + TamsulosinN/AContra-indications of Finasteride + TamsulosinN/ASpecial Precautions while taking Finasteride + TamsulosinN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Finasteride + TamsulosinN/AInteractions for Finasteride + TamsulosinN/ATypical Dosage for Finasteride + TamsulosinN/ASchedule of Finasteride + TamsulosinN/AStorage Requirements for Finasteride + TamsulosinN/AEffects of Missed Dosage of Finasteride + TamsulosinN/AEffects of Overdose of Finasteride + TamsulosinN/AFinasteride
About Finasteride5 Alpha-Reductase Inhibitor, Synthetic anti-androgen.Mechanism of Action of FinasterideThis synthetic 4-azasteroid derivative competitively inhibits steroid 5alpha reductase, which is an enzyme responsible for active androgen dehydrotestosterone (this enzyme influences the development of prostate gland, so decreasing level of this hormone relieve the symptoms associated with benign prostatic hyperplasia)from testosterone.Pharmacokinets of FinasterideAbsorption- Poorly absorbed after oral administration
Distribution- Widely distributed in the body. It crosses the blood-brain barrier. 90% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites. Two metabolites, the t-butyl side chain monohydroxylated and monocarboxylic acid metabolites have been identified that possess not more than 20% of the 5alpha-reductase inhibitory activity of finasteride.
Excretion- It is excreted through urine and feces
Onset of Action for FinasterideAfter a few monthsDuration of Action for Finasteride24hrsHalf Life of FinasterideIts plasma half life is 4.8-6 hoursSide Effects of Finasteride1. Increased libido
2. Breast tenderness
3. Impotence
4. Hypersensitivity reactions.
5. Impotence (inability to have or maintain an erection)
6. Nipple discharge
Contra-indications of FinasterideContraindicated in patients with hypersensitivity to the drugSpecial Precautions while taking Finasteride1. Hepatic dysfunction
2. Patients with large residual urine volume
3. Increase in PSA levelPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationUse with cautionChildren Related InformationMay be usedIndications for Finasteride1. Benign prostatic hyperplasia
2. 1st stage of prostate cancer
3. Hirsuitism
4. Acne
5. Adjuvant therapy of radical prostectomy
6. Androgenic baldness
Interactions for FinasterideTheophylline: Increased theophylline clearance and decreased its half-life.Typical Dosage for FinasterideOral-
Adult-
5mg/day for 6 to 12 months
Androgenic baldness: 1mg/day for 3 months or more
Schedule of FinasterideN/AStorage Requirements for FinasterideStore it at room temperature and away from excess heat and moistureEffects of Missed Dosage of FinasterideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of FinasterideGive symptomatic and supportive treatmentTamsulosin
About TamsulosinSelective Alpha1a Adrenergic Antagonist , For benign prostatic hyperplasia.Mechanism of Action of TamsulosinTamsulosin is adrenergic alpha receptor antagonist. It inhibits alpha 1A and alpha 1D subtype receptors. Tamsulosin selectively inhibits alpha 1A receptor in the prostate and leads to relaxation of smooth muscles in the bladder neck and prostate. This will improve urine flow and reduces BPH symptoms.
Adrenergic nerves releases adrenalin which produces contraction of muscles. Tamsulosin is selectively inhibit alpha 1A receptor in the prostate and bladder neck and relaxes the muscles and decrease the obstruction to the flow of urine in prostate hypertrophy.
Pharmacokinets of TamsulosinAbsorption: It is well absorbed after oral administration under fasting condition.
Distribution: It is distributed widely to tissues in protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: The drug and its metabolites are excreted primarily in the urine and about 21% is excreted through faeces.
Onset of Action for TamsulosinN/ADuration of Action for Tamsulosin9 - 15 hoursHalf Life of Tamsulosin5- 10 hoursSide Effects of Tamsulosin1. Dizziness
2. Headache
3. Abnormal ejaculation
4. Vertigo
5. Postural hypotension
6. Somnolence
7. Insomnia
8. Diarrhoea
9. Nausea
10. Back pain
11. Syncope
12. Infection
13. Rhinitis
14. Sinusitis
15. Pharyngitis
16. Rash
17. Pruritis
18. Urticaria
Contra-indications of Tamsulosin1. Hypersensitivity to TamsulosinSpecial Precautions while taking Tamsulosin1. During initiation of therapy slowly get up from chair or bed.
2. Avoid conditions in which injury could occur as a result of syncope.
3. Driving vehicle, operating machine and other hazardous woks.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Tamsulosin1. Benign Prostatic hyperplasia (BPH)
Interactions for TamsulosinCimetidine: Results in significant decrease in clearance of tamsulosin AUC.
Alpha adrenergic blocking agents: Tamsulosin should not be used in combination with other alpha adrenergics.
Typical Dosage for TamsulosinAdult: 400mg / day drug to be taken 30 minutes after the same meal each day and if sufficient response does not obtained then increase the dose to 800mg / day after 2 or 4 weeks.
Children: Not recommended
Schedule of TamsulosinN/AStorage Requirements for TamsulosinStore at room temperature. Protect from heat and light. Keep out of the reach of childrenEffects of Missed Dosage of TamsulosinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose. If treatment with Tamsulosin is missed for several days, contact doctor before restarting the medication and a lower dose may be necessary to restart the drug.Effects of Overdose of TamsulosinGive supportive measures and symptomatic treatment. Administer IV fluids and if needed give vasopressors. Monitor renal functions.Home Delivery for Finasteride + Tamsulosin in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including finasteride + tamsulosin.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for finasteride + tamsulosin and other medicines and health products. Home delivery services for finasteride + tamsulosin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take finasteride + tamsulosin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for finasteride + tamsulosin before they complete the sale. You can get this information while placing the order for finasteride + tamsulosin with the pharmacy.
Finasteride + Tamsulosin is a generic medicine name and there are several brands available for it. Some of the brands for finasteride + tamsulosin might be better known than finasteride + tamsulosin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have finasteride + tamsulosin in stock, you can ask for one of the branded alternatives for finasteride + tamsulosin.
