Carbimazole Pharmacology


About Carbimazole
Thyroid peroxidase inhibitors(thioamide),Sulfur-containing imidazole derivatives, Antithyroid.
Mechanism of Action of Carbimazole
It is a potent antithyroid drug which inhibits thyroid hormone synthesis. It binds to thyroid peroxidase and inhibits oxidation of iodide or iodotyrosil residues. It inhibits iodination of tyrosine residues in thyroglobulin and prevents coupling of iodothyrosine residues to form T3 and T4. Thyroid colloid depleted over time and blood levels of T3 &T4 are reduced
Pharmacokinets of Carbimazole
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, It crosses the placental barrier and also enters in to the breast milk, Metabolism: Metabolized in to active Methimazole, Excretion: Excreted through urine primarily as metabolites.
Onset of Action for Carbimazole
4to 8 weeks
Duration of Action for Carbimazole
12 to 24 hours
Half Life of Carbimazole
6 to 10hours
Side Effects of Carbimazole
1. Nausea
2. Fever
3. Hepatic impairment
4. Agranulocytosis
5. Transient leucopenia
6. Alopecia
7. Maculopapular rash
8. Arthralgia.
Contra-indications of Carbimazole
1. Hypersensitivity to the antithyroid drugs
2. Obstruction in the trachea.
Special Precautions while taking Carbimazole
To report to physician if sore throat, fever appears and to stop therapy
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
Indications for Carbimazole
1. Hyperthyroidism due to Grave`s disease
2. Prior to thyroidectomy
Interactions for Carbimazole
Warfarin: Increased sensitivity to warfarin in hyperthyroid state. Dose adjustment required when patient rendered euthyroid.
Typical Dosage for Carbimazole
Adults : Initial dose : 15-45mg daily in div. doses depending upon severity. Maint: 2.5-25mg daily for 12 mths.
Thyroidectomy : 15-45 mg daily in divided doses for 2-4 wks.
Schedule of Carbimazole
Storage Requirements for Carbimazole
Effects of Missed Dosage of Carbimazole
Effects of Overdose of Carbimazole

Home Delivery for Carbimazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including carbimazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for carbimazole and other medicines and health products. Home delivery services for carbimazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take carbimazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for carbimazole before they complete the sale. You can get this information while placing the order for carbimazole with the pharmacy.

Carbimazole is a generic medicine name and there are several brands available for it. Some of the brands for carbimazole might be better known than carbimazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have carbimazole in stock, you can ask for one of the branded alternatives for carbimazole.