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- Generic Medicines
- Pharmacology For Propylthiouracil
PropylthiouracilAbout PropylthiouracilA thioamide derivative, Antithyroid drug.Mechanism of Action of PropylthiouracilIt is an antithyroid drug which inhibits thyroid hormone synthesis. It binds to thyroid peroxidase and inhibits oxidation of iodide or iodotyrosil residues. It inhibits iodination of tyrosine residues in thyroglobulin and prevents coupling of iodothyrosine residues to form T3 and T4. Thyroid colloid depleted over time and blood levels of T3 &T4 are reduced. It also inhibits peripheral conversion of T4 toT3.Pharmacokinets of PropylthiouracilAbsorption: Well absorbed orally, Distribution: Widely distributed in a highly protein bound form, Metabolism: Metabolized in liver in to inactive metabolites, Excretion: Excreted through urine primarily as metabolites.Onset of Action for PropylthiouracilN/ADuration of Action for Propylthiouracil4 to 8 hoursHalf Life of Propylthiouracil1 to 2 hoursSide Effects of Propylthiouracil1. Mild papular skin rashes
3. DrowsinessContra-indications of Propylthiouracil1. Hypersensitivity to the antithyroid drugsSpecial Precautions while taking PropylthiouracilAlong with oral anticoagulantsPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Propylthiouracil1. Hyperthyroidism (long term treatment)
2. Prior to thyroidectomy
3. Prior to radiotherapy
4. Hepatic hyper metabolic state due to alcohol
Interactions for PropylthiouracilOral anticoagulants: Activity of oral anticoagulants may be potentiated.
Typical Dosage for PropylthiouracilOral: 50 to 150mg thrice daily depending up on the severity of the condition.
Maintenance dosage: 25 to 50mg twice daily to thrice daily based on the clinical status of the patient.
Schedule of PropylthiouracilN/AStorage Requirements for PropylthiouracilStore at room temperature in a well closed container.Effects of Missed Dosage of PropylthiouracilTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PropylthiouracilProvide symptomatic treatment and supportive measures.
Home Delivery for Propylthiouracil in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including propylthiouracil.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for propylthiouracil and other medicines and health products. Home delivery services for propylthiouracil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take propylthiouracil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for propylthiouracil before they complete the sale. You can get this information while placing the order for propylthiouracil with the pharmacy.
Propylthiouracil is a generic medicine name and there are several brands available for it. Some of the brands for propylthiouracil might be better known than propylthiouracil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have propylthiouracil in stock, you can ask for one of the branded alternatives for propylthiouracil.