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- Pharmacology For Gliclazide + Rosiglitazone
Gliclazide + Rosiglitazone Pharmacology
Gliclazide + Rosiglitazone
About Gliclazide + RosiglitazoneN/AMechanism of Action of Gliclazide + RosiglitazoneN/APharmacokinets of Gliclazide + RosiglitazoneN/AOnset of Action for Gliclazide + RosiglitazoneN/ADuration of Action for Gliclazide + RosiglitazoneN/AHalf Life of Gliclazide + RosiglitazoneN/ASide Effects of Gliclazide + RosiglitazoneN/AContra-indications of Gliclazide + RosiglitazoneN/ASpecial Precautions while taking Gliclazide + RosiglitazoneN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Gliclazide + RosiglitazoneN/AInteractions for Gliclazide + RosiglitazoneN/ATypical Dosage for Gliclazide + RosiglitazoneN/ASchedule of Gliclazide + RosiglitazoneN/AStorage Requirements for Gliclazide + RosiglitazoneN/AEffects of Missed Dosage of Gliclazide + RosiglitazoneN/AEffects of Overdose of Gliclazide + RosiglitazoneN/AGliclazide
About GliclazideFirst generation Sulfonylurea, Oral Antidiabetic Agent.Mechanism of Action of GliclazideIt is an antidiabetic drug which exerts it`s action by increasing insulin release from the pancreas and by improving glucose tolerance. It acts on the "sulfonylurea receptors" on pancreatic ?-cell membrane and reduces conductance of ATP sensitive K+ channels and thus causes depolarization. This enhances Ca2+ influx and degranultion and thus increases insulin secretion rate at any glucose concentration. It primarily increases 2nd phase insulin secretion and has little effect on 1st phase. It also slows hepatic degradation of insulin and minor action of reducing glucagon release and increasing Somatostatin release. It also exerts extrapancreatic action; by sensitizing the target tissues such as liver to insulin action. It increases the number of insulin receptors and through a post receptor action improving translation of receptor activation. It also possesses anti-platelet action and also reduces free radicals.Pharmacokinets of GliclazideAbsorption: Well absorbed orally.
Distribution: Distributed in to extra cellular fluids and shows protein binding up to 94%.
Metabolism: Almost completely metabolized in to inactive metabolites in liver.
Excretion: Excreted mainly through urine and also through faeces as metabolites.
Onset of Action for GliclazideN/ADuration of Action for Gliclazide12 to 24 hoursHalf Life of Gliclazide8 to 20 hoursSide Effects of Gliclazide1. Hypoglycemia
2. Nausea
3. Vomiting
4. Diarrhoea
5. Constipation
6. Headache
7. Paresthesia
8. Hypersensitivity reactions
9. Rashes
10. Photosensitivity
11. Purpura
12. Transient leucopenia
13. Agranulocytosis
14. Blood dyscrasias
Contra-indications of Gliclazide1. Hypersensitivity to the drug
2. Diabetic ketoacidosis
3. Diabetic coma
4. Renal impairment
5. Hepatic impairment
Special Precautions while taking Gliclazide1. Malnourished and deliberate individuals
2. Periods of metabolic stress
3. Hepatic diseases
4. Renal diseases
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Gliclazide1. Non insulin dependent diabetes mellitus
2. Diabetes mellitus with vascular complications
3. Diabetes with or without obesity
Interactions for GliclazideHypoglycaemic effect of gliclazide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers.
Hypoglycemic effect of gliclazide inhibited by the following drugs: b-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers.
Charcoal: Reduces the absorption of gliclazide thus reducing its efficacy or toxicity.
Digitalis glycosides: Co-administration results in increased digitalis serum levels.
Typical Dosage for Gliclazide80mg twice daily. Adjust the dosage up to 160mg twice daily based on patient`s response if required. Schedule of GliclazideHStorage Requirements for GliclazideStore at room temperature at a range of 15 to 30 degree C.in a well closed container away fro light. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of GliclazideTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of GliclazideMild hypoglycemia can be treated with oral glucose and dosage adjustment. If there is loss of consciousness or neurological findings the patient should receive rapid injection of dextrose 50%; followed by continuous infusion of dextrose 10% at a rate to maintain blood glucose levels greater than 100mg/dl. Monitor patient for 24 to 48 hours. Rosiglitazone
About RosiglitazoneThiazolidinedione derivative, Oral anti-diabetic.Mechanism of Action of RosiglitazoneThe drug exerts antidiabetic action by acting as a selective agonist for the nuclear "peroxisome proliferator-activated receptor Gama (PPAR Gama); which enhances the transcription of several insulin responsive genes. It reverses insulin resistance by stimulating GLUT4 (glucose transporter 4) expression and translocation and improves entry of glucose in to muscle and adipose tissue. It also suppresses hepatic gluconeogenesis. Activation of genes regulating fatty acid metabolism and lipogenesis in adipose tissue also contributes to the insulin sensitizing action of drug. It reduces blood glucose and HbA1c; improves glycaemic control and lowers circulating levels of Insulin.
Pharmacokinets of RosiglitazoneAbsorption: Well absorbed orally and bioavailability is about 99%, Distribution: Widely distributed in a highly protein bound form, Metabolism: Extensively metabolized in the body. Primarily metabolized through N-demethylation and hydroxylation; with subsequent conjugation, Excretion: Excreted mainly through urine (64%) and rest is excreted through faeces.Onset of Action for RosiglitazoneN/ADuration of Action for Rosiglitazone12 to 24 hoursHalf Life of Rosiglitazone3 to 4 hoursSide Effects of Rosiglitazone1. Oedema
2. Plasma volume expansion
3. Weight gain
4. Headache
5. Myalgia
6. Mild anaemia
7. Back pain
Contra-indications of Rosiglitazone1. Hypersensitivity to the drug
2. Hepatic impairment
3. Cogestive heart failure
4. Patients with moderately severe to severe cardiac disease (New York Heart Association class III and class IV cardiac diseases)
5. Incresed liver enzyme levels(ALT level greater than 2. 5 times than normal)
6. Type 1 diabetes mellitus
7. Diabetic ketoacidosis.
Special Precautions while taking Rosiglitazone1.Cardiac diseases
2.AlcoholicsPregnancy Related InformationContraindicatedOld Age Related InformationMay be usedBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Rosiglitazone1. Non-insulin dependent diabetes mellitus (as adjunct to diet and exercise)Interactions for RosiglitazoneMetformin: The pharmacokinetics of rosiglitazone was not altered following its concurrent administration in healthy volunteers.
Acarbose: Coadministration had no clinically relevant effect on the pharmacokinetics of rosiglitazone.Typical Dosage for RosiglitazoneOral: Starts with 4mg once daily in the morning or as two divided doses in the morning and evening. Increases the dose to 8mg once daily or as two divided doses; If fasting glucose levels does not improves after 12 weeks. Schedule of RosiglitazoneN/AStorage Requirements for RosiglitazoneStore at controlled room temperature at a range of 15 to 30 degree C.; in a well closed container. Protect from moisture. Keep out of reach of children.Effects of Missed Dosage of RosiglitazoneTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RosiglitazoneProvide symptomatic treatment and supportive measures.Home Delivery for Gliclazide + Rosiglitazone in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for gliclazide + rosiglitazone and other medicines and health products. Home delivery services for gliclazide + rosiglitazone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take gliclazide + rosiglitazone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for gliclazide + rosiglitazone before they complete the sale. You can get this information while placing the order for gliclazide + rosiglitazone with the pharmacy.
Gliclazide + Rosiglitazone is a generic medicine name and there are several brands available for it. Some of the brands for gliclazide + rosiglitazone might be better known than gliclazide + rosiglitazone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have gliclazide + rosiglitazone in stock, you can ask for one of the branded alternatives for gliclazide + rosiglitazone.
