Tolbutamide Pharmacology


About Tolbutamide
A first generation potassium channel blocker, Sulfonylurea derivative, Oral hypoglycemic agent.
Mechanism of Action of Tolbutamide
Tolbutamide exerts its hypoglycemic action by increasing insulin release from the pancreas and by improving glucose tolerance. It acts on the "sulfonylurea receptors" on pancreatic ?-cell membrane and reduces conductance of ATP sensitive K+ channels and thus causes depolarization. This enhances Ca2+ influx and thus increases insulin secretion rate at any glucose concentration.
Pharmacokinets of Tolbutamide
Absorption: It is rapidly absorbed from GIT. Distribution: It is distributed mainly into extra cellular fluid in protein bound form. Metabolism: It undergoes metabolism in the liver. Excretion: Drug and its metabolites are excreted in urine and faeces.
Onset of Action for Tolbutamide
30 - 60 minutes
Duration of Action for Tolbutamide
12-24 hours
Half Life of Tolbutamide
4-7 hours
Side Effects of Tolbutamide
8.Weight gain
9.Hypersensitivity reactions
Contra-indications of Tolbutamide
1.Hypersensitivity to Tolbutamide
2.Type 1 Diabetes mellitus
Special Precautions while taking Tolbutamide
1.Hepatic impairment
2.Cardiac failure
3.Renal impairment
4.Ischaemic vascular disease
7.Malnourished individuals
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Tolbutamide
Non Insulin dependent diabetes mellitus(type 2)
Interactions for Tolbutamide
Typical Dosage for Tolbutamide
Adult:500mg 2 - 4 times daily.If needed dose can be increased to 3mg/day
Schedule of Tolbutamide
Storage Requirements for Tolbutamide
Store at room temperature at a range of 15 to 30 degree a well closed container. Protect from excess heat and moisture. Keep out of reach of childre
Effects of Missed Dosage of Tolbutamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolbutamide
Mild hypoglycemia can be treated with oral glucose and dosage adjustment. If there is loss of consciousness or neurological findings the patient should receive rapid injection of dextrose 50%; followed by continuous infusion of dextrose 10% at a rate to maintain blood glucose levels greater than 100mg/dl. Monitor patient for 3 to 5 days.

Home Delivery for Tolbutamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolbutamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolbutamide and other medicines and health products. Home delivery services for tolbutamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolbutamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolbutamide before they complete the sale. You can get this information while placing the order for tolbutamide with the pharmacy.

Tolbutamide is a generic medicine name and there are several brands available for it. Some of the brands for tolbutamide might be better known than tolbutamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolbutamide in stock, you can ask for one of the branded alternatives for tolbutamide.