Clomiphene Pharmacology


About Clomiphene
A selective estrogen receptor modulator (SERM),chlorotrianisene derivative, Ovulation Stimulator ,Fertility agent.
Mechanism of Action of Clomiphene
The drug is an estrogen antagonist which exerts it`s pharmacological action by inducing ovulation. It induces gonadotropin secretion in women by blocking estrogenic feedback inhibition of pituitary. It increases the amount of LH and FSH released at each secretary pulse which results in enlargement of ovaries and ovulation.
In men increased gonadotropin levels results in increased steroidogenesis and helps in oligospermia and infertility.
Pharmacokinets of Clomiphene
Absorption: Well absorbed orally. Distribution: Distributed preferentially in to the adipose tissue. Metabolism: Metabolized in liver. Excretion: Excreted mainly through bile and faeces.
Onset of Action for Clomiphene
Duration of Action for Clomiphene
Half Life of Clomiphene
5 to 6days.
Side Effects of Clomiphene
1.Cyts in ovaries
2.Multiple pregnancy
3.Hot flushes
4.Stomach upset
6 Vomiting
8 Vertigo
9 Breast tenderness
10 Dermatitis
11 Rash
12 Urticaria
13.Increases the risk of ovarian tumor
14 Spotting
15 Alopecia
Contra-indications of Clomiphene
1. Hepatic impairment
2. Undiagnosed genital bleeding
3. Ovarian cysts not due to polycystic ovary disease
4. Uncontrolled thyroid dysfunction
5. Uncontrolled adrenal dysfunction
6. Carcinoma of genital tract
7. Pituitary tumor.
Special Precautions while taking Clomiphene
1.Therapy for infertility in females should be under direct supervision of a gynaecologist.
2.Ovarian enlargement
3.Long term therapy
4.Along with alcohol
5.Along with antidepressants
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Children Related Information
Indications for Clomiphene
1. Anovulatory infertility
2. Oligomenorrhoea
3. Post pill amenorrhoea
4. Oligospermia
5. Polycystic ovary syndrome
6. Lactation amenorrhoea.
7. Psychogenic amenorrhoea
8. Menorrhagia due to hyper plastic endometrium.
Interactions for Clomiphene
Gonadotropin Therapy: In combination, Gonadotropin therapy causes hyper-stimulation of ovary.
Lab Tests: Levels of Thyroxine and Thyroxine-binding Globulin (TBG) increased.
BSP (Bromsulphalein) Lab studies: greater than 5% retention of BSP reported in 10-20% of patients.
Typical Dosage for Clomiphene
Anovulatory infertility: 50mg once daily for 5days starting from 5th day of menstrual cycle. (Starting from any time in women who have had no recent uterine bleeding). Dose may be increased to 100mg if ovulation does not occur. Repeat the 5 day course until conception occurs or until the completion of 3 courses.
Male infertility: 25mg daily for 25 days followed by a rest period of 5days for 3 to 6 months.
Schedule of Clomiphene
Storage Requirements for Clomiphene
Store at controlled room temperature at a range of 15 to 30 degree a well closed container. Protect from light, excess heat and moisture.
Effects of Missed Dosage of Clomiphene
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Clomiphene
Provide symptomatic treatment and supportive measures.

Home Delivery for Clomiphene in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clomiphene.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clomiphene and other medicines and health products. Home delivery services for clomiphene may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clomiphene only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clomiphene before they complete the sale. You can get this information while placing the order for clomiphene with the pharmacy.

Clomiphene is a generic medicine name and there are several brands available for it. Some of the brands for clomiphene might be better known than clomiphene itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clomiphene in stock, you can ask for one of the branded alternatives for clomiphene.