Flurbiprofen Pharmacology

Flurbiprofen

About Flurbiprofen
NSAID, Oral, phenylalkanoic acid derivative, Analgesic and anti-inflammatory, Anti arthritic.
Mechanism of Action of Flurbiprofen
It reduces prostaglandin synthesis by inhibiting cyclo oxygenase enzymes both COX1 and COX2.In higher doses it reduces the thromboxane A2 synthesis by COX1 inhibition. So platelet aggregation is inhibited by this drug. After topical application in the case of ophthalmic preparation it prevents miosis by reducing ocular prostaglandins synthesis. It is a phenylalkalonic acid derivative Non Steroidal Anti Inflammatory Drug.
Pharmacokinets of Flurbiprofen
Absorption- Well absorbed orally.
Distribution-99% bound to the plasma proteins.
Metabolism- In liver it is metabolized by hydroxylation and conjugation.
Excretion-It is excreted through urine.
Onset of Action for Flurbiprofen
30-60 minutes
Duration of Action for Flurbiprofen
8-12hrs
Half Life of Flurbiprofen
6-10
Side Effects of Flurbiprofen
1. Anxiety.
2. Insomnia
3. Tremors
4. Depression
5. Heart failure
6. Visual changes
7. Renal failure
8. Thrombocytopenia
9. Aplastic anemia
10. Photosensitivity
11. Urticaria
12. Angioedema
Contra-indications of Flurbiprofen
1. Hypersensitivity to this drug
2. Peptic ulcer
3. Gastro intestinal bleeding
4. Bronchospasm
5. Hypersensitivity
6. Herpes simplex keratitis
Special Precautions while taking Flurbiprofen
1. Renal failure
2. Hyper tension
3. Hypersensitive to other Non Steroidal Anti Inflammatory Drugs
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
N/A
Indications for Flurbiprofen
1. Rheumatoid arthritis
2. Osteo arthritis
3. Ankylosing spondylitis
4. Pain in patients with dysmenorrhea.
5. Acute gout
6. Migraine

Interactions for Flurbiprofen
N/A
Typical Dosage for Flurbiprofen
Oral
Adults- 200-300mg/day in 2-4 divided doses.
Topicaly-0.03% ophthalmic solution. Add 1 drop in every ? hr to the eyes beginning 2-3 hrs before surgery.
Schedule of Flurbiprofen
H
Storage Requirements for Flurbiprofen
Storage-Store in a sealed container at room a temperature and avoid moisture.
In the case of ophthalmic preparation stored between 15 and 30 degree Celsius.
Effects of Missed Dosage of Flurbiprofen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Flurbiprofen
Supportive and symptomatic treatment should be given. Empty the stomach by emesis or gastric lavage.

Home Delivery for Flurbiprofen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including flurbiprofen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for flurbiprofen and other medicines and health products. Home delivery services for flurbiprofen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take flurbiprofen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for flurbiprofen before they complete the sale. You can get this information while placing the order for flurbiprofen with the pharmacy.

Flurbiprofen is a generic medicine name and there are several brands available for it. Some of the brands for flurbiprofen might be better known than flurbiprofen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have flurbiprofen in stock, you can ask for one of the branded alternatives for flurbiprofen.