Naproxen Pharmacology

Naproxen

About Naproxen
NSAID, 2-arylpropionic acid (profen) derivative, Analgesic, anti-inflammatory,antipyretic.
Mechanism of Action of Naproxen
Naproxen has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Naproxen inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.
Pharmacokinets of Naproxen
Absorption: Naproxen is well absorbed after oral administration and its bioavailability is about 95 %.
Distribution: It is distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver.
Excretion: Naproxen and its metabolites are excreted mainly in the urine.
Onset of Action for Naproxen
1 hours
Duration of Action for Naproxen
7 hours
Half Life of Naproxen
10-20 hours
Side Effects of Naproxen
1. Nausea
2. Vomiting
3. Diarrhoea
4. Gastrointestinal bleeding
5. Abdominal pain
6. Constipation
7. Peptic ulceration
8. Dyspepsia
9. Headache
10. Drowsiness
11. Oedema
12. Agranulocytosis
13. Neutropenia
14. Thrombocytopenia
15. Dizziness
16. Rash
17. Pruritis
Contra-indications of Naproxen
1. Hypersensitivity to Naproxen and other NSAIDs
2. Inflammatory bowel disease
3. Peptic ulcer
4. Severe renal impairment
Special Precautions while taking Naproxen
1. Hepatic impairment
2. Renal impairment
3. Hypertension
4. Gastrointestinal diseases
5. Pre existing asthma
6. Oedema
7. Heart failure
8. Myocardial infarction
9. Stroke
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Naproxen
1. Rheumatoid arthritis
2. Ankylosing spondylitis
3. Acute gout
4. Joint disorders e.g. inflammatory disease and crystal deposition in the joints
5. Osteoarthritis
6. For the relief of pain and inflammation in dental minor surgery and orthopedic
7. Dysmenorrhoea
8. Juvenile arthritis
9. Migraine
Interactions for Naproxen
N/A
Typical Dosage for Naproxen
Adult: 500 - 1 g / day in 2 divided doses
Pain, Migraine, Dysmenorrhoea, Tendonitis, and Bursitis: Initial dose: 500 mg followed by 250 mg every 6 - 8 hours.
Maximum daily dose after first day: 1250mg
Acute gout: Initial dose: 750 mg followed by 250 mg every 8 hours until attack has subsided.
Children: 5 mg / kg body weight 2 times daily
Schedule of Naproxen
H
Storage Requirements for Naproxen
Store Naproxen at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Naproxen
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Naproxen
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Naproxen in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including naproxen.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for naproxen and other medicines and health products. Home delivery services for naproxen may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take naproxen only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for naproxen before they complete the sale. You can get this information while placing the order for naproxen with the pharmacy.

Naproxen is a generic medicine name and there are several brands available for it. Some of the brands for naproxen might be better known than naproxen itself. If the pharmacy that's willing to deliver medicines to your home doesn't have naproxen in stock, you can ask for one of the branded alternatives for naproxen.