Mesterolone Pharmacology

Mesterolone

About Mesterolone

A synthetic, orally effective Dihydrotestosterone derivative, Androgen.

Mechanism of Action of Mesterolone

Mesterolone is an orally active synthetic Testosterone derivative. Testosterone and it`s reduced form; dihydrotestosterone binds with cytoplasmic testosterone receptors in androgen responsive organs and tissues and forms hormone receptor complex. This hormone-receptor complex binds with DNA and enhances DNA transcription and formation of mRNA which ultimately leads to modification of protein synthesis. It promotes growth and development of male sex organs and secondary sexual characters and maintains proper sexual functioning. It also exerts anabolic effect on skeleton and skeletal muscles and accelerates erythropoiesis. It causes less feed back inhibition of gonadotropin secretion and spermatogenesis than testosterone. Also it does not cause hepatic impairment.

Pharmacokinets of Mesterolone

Absorption: Well absorbed orally, Distribution: Widely distributed in a plasma protein bound form, Metabolism: Itundergoes metabolism. Excretion: Excreted mainly through urine and also through faeces.

Onset of Action for Mesterolone

N/A

Duration of Action for Mesterolone

N/A

Half Life of Mesterolone

N/A

Side Effects of Mesterolone

1.Priapism
2.Increased libido
3.Increased frequency and duration of erection
4.Hypercalcaemia
5.Hypernatreamia
6.Hyperkalaemia
7.Hyperphosphataemia
8.Impaired glucose tolerance
9.Retention of water
10.Weight gain
11.Oedema
12.Excessive hormonal effects in men
13.Premature epiphyseal closure
14.Acne
15.Headache
16.Anxiety
17.Depression
18.Sleep apnea

Contra-indications of Mesterolone

1.Hypersensitivity to the drug
2.Prostate cancer
3.Severe hepatic impairment
4.Severe renal impairment
5.Women.

Special Precautions while taking Mesterolone

1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disorders
4.Congestive heart failure
5.Epilepsy
6.Migraine
7.Examine prostate prophylactically

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated.

Children Related Information

Contraindicated.

Indications for Mesterolone

1.Male hypogonadism
2.Male infertility
3.Andropause
4.Lower androgen levels

Interactions for Mesterolone

N/A

Typical Dosage for Mesterolone

Oral: initially 25 mg 8th hourly;
Maximum dose: 50mg/dose
Maintenance dosage: 25 mg once or twice daily, depending on patient`s response
For infertility continue treatment for 3months

Schedule of Mesterolone

Storage Requirements for Mesterolone

Store at room temperature at a range of 15 to 30 degree C.

Effects of Missed Dosage of Mesterolone

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Mesterolone

Provide symptomatic treatment and supportive measures.

Home Delivery for Mesterolone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mesterolone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mesterolone and other medicines and health products. Home delivery services for mesterolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mesterolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mesterolone before they complete the sale. You can get this information while placing the order for mesterolone with the pharmacy.

Mesterolone is a generic medicine name and there are several brands available for it. Some of the brands for mesterolone might be better known than mesterolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mesterolone in stock, you can ask for one of the branded alternatives for mesterolone.