Mefenamic Acid Pharmacology

Mefenamic Acid

About Mefenamic Acid
NSAID, Analgesic,antiinflammatory.
Mechanism of Action of Mefenamic Acid
Mefenamic acid has analgesic, anti-inflammatory and antipyretic action. It acts by inhibiting Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other analgesics. Mefenamic acid inhibits cyclo-oxygenase enzyme and antagonizes prostaglandin actions.
Pharmacokinets of Mefenamic Acid
Absorption: Mefenamic acid is well absorbed after oral administration. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Mefenamic acid and its metabolites are excreted mainly in the urine.
Onset of Action for Mefenamic Acid
1-2 hours.
Duration of Action for Mefenamic Acid
6 hours.
Half Life of Mefenamic Acid
2-4 hours.
Side Effects of Mefenamic Acid
5.Gastrointestinal bleeding
6.Abdominal distress
8.Peptic ulcer
15.Aplastic anaemia
Contra-indications of Mefenamic Acid
1.Hypersensitivity to Mefenamic acid and other NSAIDs
2.Inflammatory bowel disease
3.Peptic ulcer
Special Precautions while taking Mefenamic Acid
1.Hepatic impairment
2.Renal impairment
4.Gastrointestinal diseases
5.Pre existing asthma
6.Patient on anticoagulant therapy
7.Heart failure
8.Myocardial infarction
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Below 14 years: contraindicated
NEONATES: used only to close the patent ductus arteriosus as IV form only
Indications for Mefenamic Acid
1.Muscular aches
2.Primary Dysmenorrhoea
4.Acute gout
5.Dental pain
6.Patent ductus arteriosus
Interactions for Mefenamic Acid
Typical Dosage for Mefenamic Acid
Adult: initial dose: 500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children above 14 years:
500 mg followed by 250 mg every 6 hours. Treatment is continued maximum up to 1 week.
Children below 14 years: not recommended.

Schedule of Mefenamic Acid
Storage Requirements for Mefenamic Acid
Store Mefenamic acid at room temperature in a tightly closed light resistant container.
Effects of Missed Dosage of Mefenamic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Mefenamic Acid
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Mefenamic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including mefenamic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for mefenamic acid and other medicines and health products. Home delivery services for mefenamic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take mefenamic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for mefenamic acid before they complete the sale. You can get this information while placing the order for mefenamic acid with the pharmacy.

Mefenamic Acid is a generic medicine name and there are several brands available for it. Some of the brands for mefenamic acid might be better known than mefenamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have mefenamic acid in stock, you can ask for one of the branded alternatives for mefenamic acid.