Danazol Pharmacology


About Danazol
Synthetic steroid ethisterone derivative, an isoxazole of testosterone, Synthetic Androgen.
Mechanism of Action of Danazol
It is an orally effective ethisterone derivative; attenuated androgen which suppresses gonadotropin secretion from pituitary in both men and women and results in inhibition of testicular and ovarian function. It suppresses gonadal function directly and by inhibiting steroidogenic enzymes. It causes endometrial atrophy and amenorrhoea. It also decreases the rate of growth and nodularity of abnormal breast tissue in fibrocystic breast disease. It has mild androgenic, anabolic, and progestational activity. Androgenic effects increases the levels of C1 and C4 components of complements which reduce frequency and severity of attacks associated with hereditary angioedema.
Pharmacokinets of Danazol
Absorption: Well absorbed orally, Metabolism: Metabolized in to 2-hydroxy methyl ethisterone and other metabolites.

Onset of Action for Danazol
Duration of Action for Danazol
Half Life of Danazol
Side Effects of Danazol
2.Loss of libido in men
3.Hot flushes in women
4.Night sweats
5.Muscle cramps
7.Gastrointestinal upset
8.Abnormal liver enzyme tests
9.Cholestatic jaundice
10.Androgenic effects in women
13.Deepening of voice
15.Weight gain
16.Muscle spasm
18.Sleep disorders.
Contra-indications of Danazol
1.Abnormal genital bleeding of unknown etiology
3.Cardiac oedema
4.Renal impairment
5.Hepatic impairment
6.Pelvic infection
7.Undiagnosed uterine or ovarian masses
8.Jaundice on oral contraceptive therapy.
Special Precautions while taking Danazol
5.Long term therapy
6.Monitor hepatic function tests
Pregnancy Related Information
Old Age Related Information
May be used
Breast Feeding Related Information
Children Related Information
Indications for Danazol
2.Fibrocystic breast disease
5.Hereditary angioedema.
Interactions for Danazol
Insulin: Increase in insulin requirement in diabetics due to insulin resistance.
Warfarin: Potentiation of anti-coagulant effect.
Oral contraceptives: Interfere with danazol action.
Anti-epileptics: May require adjustment in their doses.
Lab tests: Glucose Tolerance.
Tests: Decreased glucose tolerance.
Liver function Tests: Elevated values reported.
Typical Dosage for Danazol
Mild endometriosis: Starts with 100 to 200mg 12th hourly up to 6months. Adjust the dosage based on patient`s response.
Moderate to severe endometriosis: 400mg 12th hourly up to 6months.
Fibrocystic breast disease, Gynaecomastia:
100 to 400mg/day as two divided doses for 2 to 6months.
Menorrhagia: 200mg/day for 3 months.
Hereditary angioedema: 200mg 12th hourly to 8th hourly until therapeutic effect is obtained. Then reduce the dosage to half at 1 to 3 month intervals.
Schedule of Danazol

Storage Requirements for Danazol
Store at room temperature below 30 degree C.
Effects of Missed Dosage of Danazol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Danazol
Empty stomach by induced emesis and gastric lavage. Reduce absorption by administration of activated charcoal. Provide symptomatic treatment and supportive measures.

Home Delivery for Danazol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including danazol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for danazol and other medicines and health products. Home delivery services for danazol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take danazol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for danazol before they complete the sale. You can get this information while placing the order for danazol with the pharmacy.

Danazol is a generic medicine name and there are several brands available for it. Some of the brands for danazol might be better known than danazol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have danazol in stock, you can ask for one of the branded alternatives for danazol.