Tibolone Pharmacology


About Tibolone
A synthetic steroid hormone,Selective tissue estrogenic activity regulator, Female sexual dysfunction drug.
Mechanism of Action of Tibolone
The drug metabolized in a tissue selective manner in to three metabolites which have estrogenic, progestogenic and weak androgenic properties. It restores plasma endorphin level in post menopausal women and stabilizes the hypothalamic pituitary systems. It increases bone mineral density and raises gonadotropin levels. It decreases vasomotor symptoms with out stimulating endometrium. It improves urogenital atrophy, psychological symptoms, libido and osteoporosis.
Pharmacokinets of Tibolone
Absorption: Well absorbed orally
Onset of Action for Tibolone
Duration of Action for Tibolone
Half Life of Tibolone
Side Effects of Tibolone
1.Weight gain
2.Vaginal spotting(occasional)
3.Increased facial hair
4.Ankle oedema
8.Gastrointestinal disturbances
9.Abdominal pain
15.Visual disturbances
16.Changes in liver function tests
Contra-indications of Tibolone
1.Hormone dependent carcinoma
2.Undiagnosed vaginal bleeding
3.Thromboembolic disorders
4.Severe liver diseases
5.Cardiovascular diseases
6.Cerebrovascular diseases
Special Precautions while taking Tibolone
1.Use only after 12 months of last menstrual period
2. Migraine
4.Renal impairment
5.Hepatic impairment
6.Cholestatic jaundice
8.Diabetes mellitus
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Tibolone
1.Menopausal vasomotor symptoms due to estrogen deficiency,
Interactions for Tibolone
Antibacterials: Rifampicin: Accelerates metabolism (reduced plasma concentration).
Antiepileptics: Carbamazapine, phenobarbitone, phenytoin, primidone: Accelerate metabolism.
Typical Dosage for Tibolone
Oral: 2.5mg/day
Schedule of Tibolone
Storage Requirements for Tibolone
Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.

Effects of Missed Dosage of Tibolone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tibolone
Provide supportive treatment

Home Delivery for Tibolone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tibolone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tibolone and other medicines and health products. Home delivery services for tibolone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tibolone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tibolone before they complete the sale. You can get this information while placing the order for tibolone with the pharmacy.

Tibolone is a generic medicine name and there are several brands available for it. Some of the brands for tibolone might be better known than tibolone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tibolone in stock, you can ask for one of the branded alternatives for tibolone.