Tolfenamic Acid Pharmacology

Tolfenamic Acid

About Tolfenamic Acid
NSAID, N-Arylanthranilic acid derivative, Antipyretic,Analgesic,antiinflammatory.
Mechanism of Action of Tolfenamic Acid
Tolfenamic acid acts by inhibition of Prostaglandin (PGs) synthesis and their release at the site of injury. Prostaglandins cause tenderness and amplify the action of other algesics. Tolfenamic acid does not affect the tenderness induced by PGs but block the pain producing mechanism induced by inflammatory mediators by inhibiting the enzyme cyclo-oxygenase.
Pharmacokinets of Tolfenamic Acid
Absorption: Tolfenamic acid is readily absorbed from the gastrointestinal tract.
Distribution: It is distributed mainly in protein bound form. It is distributed into breast milk also. Metabolism: It is metabolised in the liver. Both metabolite and the drug are conjugated with glucuronic acid.
Excretion: 90% of the drug is excreted in the urine and the remaining in faeces.
Onset of Action for Tolfenamic Acid
Duration of Action for Tolfenamic Acid
Half Life of Tolfenamic Acid
Side Effects of Tolfenamic Acid
1. Nausea
2. Vomiting
3. Diarrhoea
4. Constipation
5. Abdominal pain
6. Headache
7. Tremor
8. Fatigue
9. Ulceration of the stomach
10. Vertigo
11. Euphoria
12. Dysuria
13. Rash
14. Green coloration of urine
15. Bleeding disorders
Contra-indications of Tolfenamic Acid
1. Severe renal impairment
2. Severe hepatic impairment
3. Peptic ulcer
Special Precautions while taking Tolfenamic Acid
1. Renal impairment
2. Hepatic impairment
Pregnancy Related Information
Old Age Related Information
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Tolfenamic Acid
1. Migraine
2. Dysmenorrhoea
3. Rheumatoid arthritis
4. Osteoarthritis
Interactions for Tolfenamic Acid
Typical Dosage for Tolfenamic Acid
Adult: 100 to 200 mg three times daily.
Migraine: 200 mg by mouth when the first symptoms appear; if a satisfactory response is not obtained this dose may be repeated once after 1 to 2 hours.
Schedule of Tolfenamic Acid
Storage Requirements for Tolfenamic Acid
Store at 15 - 25 degree C. Protect from heat and moisture. Keep out of the reach of children.
Effects of Missed Dosage of Tolfenamic Acid
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Tolfenamic Acid
Give supportive measures and symptomatic treatment.

Home Delivery for Tolfenamic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including tolfenamic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for tolfenamic acid and other medicines and health products. Home delivery services for tolfenamic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take tolfenamic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for tolfenamic acid before they complete the sale. You can get this information while placing the order for tolfenamic acid with the pharmacy.

Tolfenamic Acid is a generic medicine name and there are several brands available for it. Some of the brands for tolfenamic acid might be better known than tolfenamic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have tolfenamic acid in stock, you can ask for one of the branded alternatives for tolfenamic acid.