Chloramphenicol (Eye/Ear Drops) Pharmacology

Chloramphenicol (Eye/Ear Drops)

About Chloramphenicol (Eye/Ear Drops)
Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.
Mechanism of Action of Chloramphenicol (Eye/Ear Drops)
Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)
Absorption: Only a very small amount of the drug enters in to the systemic circulation:
Onset of Action for Chloramphenicol (Eye/Ear Drops)
Duration of Action for Chloramphenicol (Eye/Ear Drops)
Half Life of Chloramphenicol (Eye/Ear Drops)
Side Effects of Chloramphenicol (Eye/Ear Drops)
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)
Contra-indications of Chloramphenicol (Eye/Ear Drops)
1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)
Special Precautions while taking Chloramphenicol (Eye/Ear Drops)
1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments last
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Use with caution
CHILDREN below 2 years: contraindicated
Indications for Chloramphenicol (Eye/Ear Drops)
1.Bacterial conjunctivitis
2.Corneal ulcers
4.Ocular infections
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery

Interactions for Chloramphenicol (Eye/Ear Drops)
Typical Dosage for Chloramphenicol (Eye/Ear Drops)
Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)
Storage Requirements for Chloramphenicol (Eye/Ear Drops)
Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of children
Effects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chloramphenicol (Eye/Ear Drops)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Home Delivery for Chloramphenicol (Eye/Ear Drops) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including chloramphenicol (eye/ear drops).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chloramphenicol (eye/ear drops) and other medicines and health products. Home delivery services for chloramphenicol (eye/ear drops) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take chloramphenicol (eye/ear drops) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chloramphenicol (eye/ear drops) before they complete the sale. You can get this information while placing the order for chloramphenicol (eye/ear drops) with the pharmacy.

Chloramphenicol (Eye/Ear Drops) is a generic medicine name and there are several brands available for it. Some of the brands for chloramphenicol (eye/ear drops) might be better known than chloramphenicol (eye/ear drops) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chloramphenicol (eye/ear drops) in stock, you can ask for one of the branded alternatives for chloramphenicol (eye/ear drops).