Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) Pharmacology

Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)

About Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
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Mechanism of Action of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
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Pharmacokinets of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
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Onset of Action for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Duration of Action for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Half Life of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Side Effects of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Contra-indications of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Special Precautions while taking Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Pregnancy Related Information
Contraindicated; since Chloramphenicol is contraindicated in pregnancy; the combination generic is contraindicated in pregnancy.
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; since Chloramphenicol is contraindicated in breast feeding; the combination generic is contraindicated in breast feeding mother.
Children Related Information
N/A
Indications for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
1.Ocular infections
Interactions for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Typical Dosage for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
1 - 2 drop should be instilled in the eye 2 - 4 times daily
Schedule of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Storage Requirements for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Effects of Missed Dosage of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A
Effects of Overdose of Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.)
N/A

Chloramphenicol (Eye/Ear Drops)

About Chloramphenicol (Eye/Ear Drops)
Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.
Mechanism of Action of Chloramphenicol (Eye/Ear Drops)
Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)
Absorption: Only a very small amount of the drug enters in to the systemic circulation:
Onset of Action for Chloramphenicol (Eye/Ear Drops)
N/A
Duration of Action for Chloramphenicol (Eye/Ear Drops)
N/A
Half Life of Chloramphenicol (Eye/Ear Drops)
N/A
Side Effects of Chloramphenicol (Eye/Ear Drops)
1.Burning
2.Stinging
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)
Contra-indications of Chloramphenicol (Eye/Ear Drops)
1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)
Special Precautions while taking Chloramphenicol (Eye/Ear Drops)
1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments last
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
CHILDREN below 2 years: contraindicated
Indications for Chloramphenicol (Eye/Ear Drops)
EYE DROPS:
1.Bacterial conjunctivitis
2.Corneal ulcers
3.Trachoma
4.Ocular infections
EAR DROPS:
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery

Interactions for Chloramphenicol (Eye/Ear Drops)
N/A
Typical Dosage for Chloramphenicol (Eye/Ear Drops)
Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)
N/A
Storage Requirements for Chloramphenicol (Eye/Ear Drops)
Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of children
Effects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Chloramphenicol (Eye/Ear Drops)
Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes.

Prednisolone (Eye Pre.)

About Prednisolone (Eye Pre.)
Ophthalmic synthetic Glucocorticoid, Ophthalmic anti-inflammatory.
Mechanism of Action of Prednisolone (Eye Pre.)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts more selective glucocorticoid action with little mineralocorticoid actions.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction. Prednisolone acetate 1% ophthalmic solution is used for inflammation of eye. Prednisolone acetate is 3 to 5 times more active than Hydrocortisone.

Pharmacokinets of Prednisolone (Eye Pre.)
Absorption: It is absorbed after instilled into the eye.
Onset of Action for Prednisolone (Eye Pre.)
N/A
Duration of Action for Prednisolone (Eye Pre.)
N/A
Half Life of Prednisolone (Eye Pre.)
N/A
Side Effects of Prednisolone (Eye Pre.)
1.Transient burning
2.Stinging
3.Ocular irritation
4.Blurred vision
5.Allergic reactions
Contra-indications of Prednisolone (Eye Pre.)
1.Hypersensitivity to Prednisolone eye preparations
2.Epithelial herpes simplex keratitis
3.Bacterial and fungal infection of the eye
Special Precautions while taking Prednisolone (Eye Pre.)
1.Prolonged use
2.Cataract
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
Indications for Prednisolone (Eye Pre.)
Inflammation of eye
Interactions for Prednisolone (Eye Pre.)
N/A
Typical Dosage for Prednisolone (Eye Pre.)
Instil 1-2 drops into the affected eye 2-4 times daily.
Schedule of Prednisolone (Eye Pre.)
N/A
Storage Requirements for Prednisolone (Eye Pre.)
Store in a cool place. Protect from light. Keep out of the reach of children.
Effects of Missed Dosage of Prednisolone (Eye Pre.)
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Prednisolone (Eye Pre.)
Give supportive measures and symptomatic treatment.

Home Delivery for Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) and other medicines and health products. Home delivery services for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take chloramphenicol (eye/ear drops) + prednisolone (eye pre.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) before they complete the sale. You can get this information while placing the order for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) with the pharmacy.

Chloramphenicol (Eye/Ear Drops) + Prednisolone (Eye Pre.) is a generic medicine name and there are several brands available for it. Some of the brands for chloramphenicol (eye/ear drops) + prednisolone (eye pre.) might be better known than chloramphenicol (eye/ear drops) + prednisolone (eye pre.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have chloramphenicol (eye/ear drops) + prednisolone (eye pre.) in stock, you can ask for one of the branded alternatives for chloramphenicol (eye/ear drops) + prednisolone (eye pre.).