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- Pharmacology For Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)
Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.) Pharmacology
Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)
About Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AMechanism of Action of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/APharmacokinets of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AOnset of Action for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ADuration of Action for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AHalf Life of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ASide Effects of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AContra-indications of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AInteractions for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ATypical Dosage for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ASchedule of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AStorage Requirements for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/AEffects of Overdose of Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.)N/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Chloramphenicol (Eye/Ear Drops)
About Chloramphenicol (Eye/Ear Drops)Bacteriostatic broad-spectrum antibiotic, ophthalmic antibacterial agent for ocular infections.Mechanism of Action of Chloramphenicol (Eye/Ear Drops)Chloramphenicol is a broad spectrum antibiotic which is primarily bacteriostatic at low concentration and exerts bactericidal action at higher concentration. It acts by inhibiting bacterial protein synthesis. Chloramphenicol attaches to 50S subunit of ribosome and interfering with transfer of elongating peptide chain to the newly attached aminoacyl-tRNA at the ribosome-m RNA complex. It prevents the access of aminoacyl-tRNA to the acceptor site for amino acid incorporation. By acting as a peptide analogue it inhibits peptide bond formation.
Chloramphenicol eye/ear drops or eye ointment which are applied to the eye/ear directly act on the bacteria which produces infection.
Pharmacokinets of Chloramphenicol (Eye/Ear Drops)Absorption: Only a very small amount of the drug enters in to the systemic circulation:Onset of Action for Chloramphenicol (Eye/Ear Drops)N/ADuration of Action for Chloramphenicol (Eye/Ear Drops)N/AHalf Life of Chloramphenicol (Eye/Ear Drops)N/ASide Effects of Chloramphenicol (Eye/Ear Drops)1.Burning
2.Stinging
3.Hypersensitivity reactions( Anaphylaxis, Angioneurotic edema, Urticaria, Fever, Vesicular and maculopapular dermatitis)Contra-indications of Chloramphenicol (Eye/Ear Drops)1.Hypersensitivity to Chloramphenicol
2.Myelosuppression during previous exposure to Chloramphenicol
3.Blood dyscrasias
4.Perforated ear drum (ear drops)Special Precautions while taking Chloramphenicol (Eye/Ear Drops)1.Prolonged use
2.If irritation occurs then discontinue the use of medicaments
3.Avoid contact lenses
4.Avoid driving vehicle or operating machine since Chloramphenicol eye drops produces blurred vision
5.If you are using more than one type of eye drop you should administer them at least five minutes apart, to prevent the second drop washing away the first. Use eye gels or ointments lastPregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 2 years: contraindicatedIndications for Chloramphenicol (Eye/Ear Drops)EYE DROPS:
1.Bacterial conjunctivitis
2.Corneal ulcers
3.Trachoma
4.Ocular infections
EAR DROPS:
1.Bacterial Otitis externa
2.Chronic Otitis media
3.Pre and post aural or mastoid surgery
Interactions for Chloramphenicol (Eye/Ear Drops)N/ATypical Dosage for Chloramphenicol (Eye/Ear Drops)Chloramphenicol eye drops 0.4%, 0.5% and 1% and eye ointments 1% w/v is available.
Eyes: 1 drop should be instilled in the infected eye every 2 hours for 2 days and thereafter every 4 hours for up to 5 days. Do not use during sleep.
Chloramphenicol 5% w/v drop is used
Ears: The area should be cleaned and 2 - 3 drops instilled in the infected ear 3 - 4 times a day for up to 1 week
Children: 1 - 2 drops 3 times daily.
Schedule of Chloramphenicol (Eye/Ear Drops)N/AStorage Requirements for Chloramphenicol (Eye/Ear Drops)Stored in a refrigerator at 2? to 8?C.Protect from heat and light. Opened eye drops should be discarded after 5 days. Keep out of the reach of childrenEffects of Missed Dosage of Chloramphenicol (Eye/Ear Drops)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Chloramphenicol (Eye/Ear Drops)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Polymyxin B (Eye Prep.)
About Polymyxin B (Eye Prep.)Basic polypeptide(Polymyxin)antibiotic, Ophthalmic Antibiotic.Mechanism of Action of Polymyxin B (Eye Prep.)Polymixin B is a member of poly peptide antibiotic. Being poly peptide they exert a detergent like effect. They have high affinity for phospholipids. Peptide molecules orient between these phospholipids and cause cell membrane distortion and amino acids and ions come out with in the cell. Polymixin B binds to the lipid A portion of endotoxin (lipopolysaccharide portion of the outer membrane of gram negative bacteria) and inactivates this molecule. Polymixin B is useful only against gram negative bacteria.Pharmacokinets of Polymyxin B (Eye Prep.)Absorption: Absorption of the drug after ophthalmic use is minimal.Onset of Action for Polymyxin B (Eye Prep.)N/ADuration of Action for Polymyxin B (Eye Prep.)N/AHalf Life of Polymyxin B (Eye Prep.)N/ASide Effects of Polymyxin B (Eye Prep.)1.Burning
2.Stinging
3.Irritation
4.Itching
5.Redness
6.Blurred vision
7.Eyelid swelling
8.Tearing
9.Sensitivity to light.
Contra-indications of Polymyxin B (Eye Prep.)Hypersensitivity to Polymixin BSpecial Precautions while taking Polymyxin B (Eye Prep.)1. Prolonged use
2. If irritation occurs then discontinue the use of medicaments
3. Avoid contact lenses
4. Wear sun glasses if sensitivity to sunlight occurs
5. Avoid driving vehicle since it causes blurred vision
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
Indications for Polymyxin B (Eye Prep.)1.Conjunctivitis
2.Corneal ulcers
3.Keratitis
4.Blepnaritis
5.Pre and post ocular surgery
6.Prophylaxis of ocular bacterial infections
Interactions for Polymyxin B (Eye Prep.)N/ATypical Dosage for Polymyxin B (Eye Prep.)Eye drops: Initial dose: Instill 1 - 2 drop every 2 - 6 hours for 2 - 3 days and then reduce the frequency of instillation.
Eye ointment: Apply 1.5cm ribbon every 3 hours in a day.
Schedule of Polymyxin B (Eye Prep.)N/AStorage Requirements for Polymyxin B (Eye Prep.)Store at15 - 25 degree C in a dry place. Protect from light. Do not freeze. Keep out of the reach of children. Avoid use of medicament 1 month after opening.Effects of Missed Dosage of Polymyxin B (Eye Prep.)Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Polymyxin B (Eye Prep.)Give supportive measures and symptomatic treatment. The exposed eye should be irrigated with copious amounts of water for at least 15 minutes. Home Delivery for Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.) in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.).
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) and other medicines and health products. Home delivery services for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) before they complete the sale. You can get this information while placing the order for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) with the pharmacy.
Dexamethasone (Eye Pre.) + Chloramphenicol (Eye/Ear Drops) + Polymyxin B (Eye Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) might be better known than dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.) in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + chloramphenicol (eye/ear drops) + polymyxin b (eye prep.).
