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- Pharmacology For Dexamethasone (Eye Pre.) + Neomycin + Boric acid
Dexamethasone (Eye Pre.) + Neomycin + Boric acid Pharmacology
Dexamethasone (Eye Pre.) + Neomycin + Boric acid
About Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AMechanism of Action of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/APharmacokinets of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AOnset of Action for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ADuration of Action for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AHalf Life of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ASide Effects of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AContra-indications of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ASpecial Precautions while taking Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AInteractions for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ATypical Dosage for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ASchedule of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AStorage Requirements for Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AEffects of Missed Dosage of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/AEffects of Overdose of Dexamethasone (Eye Pre.) + Neomycin + Boric acidN/ADexamethasone (Eye Pre.)
About Dexamethasone (Eye Pre.)N/AMechanism of Action of Dexamethasone (Eye Pre.)The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Dexamethasone drops are used to treat inflammatory conditions of the eye. It provides relief from inflammation, redness, irritation, allergies and other conditions.
Pharmacokinets of Dexamethasone (Eye Pre.)Absorption: Dexamethasone is minimally absorbed after instillation into the eyeOnset of Action for Dexamethasone (Eye Pre.)N/ADuration of Action for Dexamethasone (Eye Pre.)N/AHalf Life of Dexamethasone (Eye Pre.)N/ASide Effects of Dexamethasone (Eye Pre.)1.Burning
2.Redness
3.Stinging in the eye
4.Blurred vision
Contra-indications of Dexamethasone (Eye Pre.)1.Hypersensitivity to DexamethasoneSpecial Precautions while taking Dexamethasone (Eye Pre.)1.Cataracts
2.Contact lens wearer
3.Diabetes
4.Glaucoma
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Dexamethasone (Eye Pre.)1.Ophthalmic disorders
2.Eye inflammationInteractions for Dexamethasone (Eye Pre.)N/ATypical Dosage for Dexamethasone (Eye Pre.)Ophthalmic disorders:Apply 0.05-0.1% into the affected eye.
Eye inflammation: Instill 0.1% of the solution 4- 6 times daily.Dose can be reduced if symptoms are controlled.
Schedule of Dexamethasone (Eye Pre.)N/AStorage Requirements for Dexamethasone (Eye Pre.)Store at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of Dexamethasone (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Dexamethasone (Eye Pre.)Give supportive measures and symptomatic treatment.Neomycin
About NeomycinAn aminoglycoside, Antibiotic, Ammonium Detoxicant.Mechanism of Action of NeomycinThis aminoglycoside cause protein synthesis inhibition by "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.Pharmacokinets of NeomycinAbsorption- Poorly absorbed after oral administration
Distribution- Rapidly distributed in the body after oral administration. 30% bound to the plasma proteins. It crosses the placenta
Metabolism- Not metabolized
Excretion- Excreted through urine and feces (primarily as unchanged form). It also excreted through breast milk
Onset of Action for Neomycin1 to 4 hr after oral administrationDuration of Action for Neomycin8hrs after oral administrationHalf Life of NeomycinIts plasma half life is 2 to 3 hrsSide Effects of Neomycin1. Rash
2. Diarrhoea
3. Inflammation of the large intestine (colitis)
4. Nausea
5. Vomiting
6. Ototoxicity
7. Damage to the kidneys
8. Damage to vestibular function within the ear
Contra-indications of Neomycin1. Hypersensitivity to the drug or any ingredients of it
2. Hypersensitivity to other amino glycosides
3. Intestinal obstruction
Special Precautions while taking Neomycin1. Impaired renal function
2. Neuromuscular disorder
3. Ulcerative bowel lesions
4. Extensive dermatologic conditions
5. Any other eye infection or condition
6. Glaucoma
7. Cataract surgery
8. Blockage of the bowel
9. Eighth-cranial-nerve disease (loss of hearing and/or balance)
10. Kidney disease
11. Myasthenia gravis
12. Parkinson`s disease
13. Ulcers of the bowel
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Neomycin1. Coma due to liver disease
2. Preventing infection following surgery
3. Topical infections
4. Systemic infections
Interactions for NeomycinN/ATypical Dosage for NeomycinOphthalmic suspension:
Adults-
1 or 2 drops every three or four hours- For eye infection
Oral (solution, tablets):
Adults and teenagers-
1 to 3 grams every six hours for five or six days- coma from liver disease
Adults and teenagers-
1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery- cleaning the bowel before surgery.
Children-
14.7 milligrams mg/kg or 6.7 mg/ pound every four hours for three days
Ear preparation:
Adults and children-
2 to 5 drops into ear canal 3 to 4 times daily for 7 to 10 days- External ear canal infection
Schedule of NeomycinCStorage Requirements for NeomycinEye preparations store in the refrigerator protected from strong light. Do not freeze. Others are stored at <250C. Keep out of reach of children.Effects of Missed Dosage of NeomycinTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of NeomycinGive symptomatic and supportive treatment. Provide haemodialysis or peritoneal dialysis to remove the drug. Treated with calcium salts or anticholinesterase to reverses neuromuscular blockade. Administer activated charcoal to prevent the further absorption of drugBoric acid
About Boric acidA weak acid, as mild antibiotic against fungal or bacterial infection, An eye wash to cleanse or irrigate the eyes, antiseptic and emulsifier.Mechanism of Action of Boric acidN/APharmacokinets of Boric acidN/AOnset of Action for Boric acidN/ADuration of Action for Boric acidN/AHalf Life of Boric acidN/ASide Effects of Boric acid1.Decreased vision
2.Redness of the eye
Contra-indications of Boric acid1.Hypersensitivity to Boric acidSpecial Precautions while taking Boric acid1.Hypertension
2.Blood vessel disease
3.Allergic to any medicine
4.Contact lenses
5.Open sores in or near the eyes
6.Do not use on damaged or broken skinPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below 3 years:ContraindicatedIndications for Boric acid1.As an irrigation solution to cleanse and treat irritated eyesInteractions for Boric acidN/ATypical Dosage for Boric acidAs directed by the physician
Apply boric acid eye solution with the aid of an eyecup. Fill the eyecup halfway with the solution, press tightly to the wide open eye, and tilt head back. Move the eyeball around to ensure full contact with the solution. Avoid contamination of the rim and inside of the eyecup by rinsing it with clean water immediately before and after each use. Schedule of Boric acidN/AStorage Requirements for Boric acidStore medicine away from heat and direct light. Keep out of the reach of children.Effects of Missed Dosage of Boric acidIt is usually only used when needed for irritated eyes. Missing a dose is usually not harmful.Effects of Overdose of Boric acidGive supportive measures and symptomatic treatment.Home Delivery for Dexamethasone (Eye Pre.) + Neomycin + Boric acid in Your City
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Dexamethasone (Eye Pre.) + Neomycin + Boric acid is a generic medicine name and there are several brands available for it. Some of the brands for dexamethasone (eye pre.) + neomycin + boric acid might be better known than dexamethasone (eye pre.) + neomycin + boric acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexamethasone (eye pre.) + neomycin + boric acid in stock, you can ask for one of the branded alternatives for dexamethasone (eye pre.) + neomycin + boric acid.
