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- Pharmacology For Diclofenac Potassium
Diclofenac Potassium Pharmacology
Diclofenac PotassiumAbout Diclofenac PotassiumNSAID, anti-inflammatory ,antipyretic and analgesic.Mechanism of Action of Diclofenac PotassiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (((PGs))). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake.Pharmacokinets of Diclofenac PotassiumAbsorption: Diclofenac potassium is rapidly absorbed after oral administration. It undergoes first pass metabolism. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac potassium is metabolised in the liver to mainly 4 hydroxy Diclofenac. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac PotassiumAnalgesic action: with in 60 minutes and Antirheumatic action with in 2 weeksDuration of Action for Diclofenac Potassium12hoursHalf Life of Diclofenac Potassium1-2 hoursSide Effects of Diclofenac Potassium1.Nausea
9.Ulceration of the stomach or intestine
Contra-indications of Diclofenac Potassium1.Hypersensitivity to Diclofenac and other Non steroidal anti inflammatory drugs(((NSAID)))
Special Precautions while taking Diclofenac Potassium1.Hepatic impairment
4.Blood clotting disorders
8.Cautioned against driving, operating or activities requiring concentration
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Potassium1.Rheumatoid arthritis
4.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
6.For the relief of pain and inflammation in dental minor surgery and orthopedic
Interactions for Diclofenac PotassiumN/ATypical Dosage for Diclofenac PotassiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Schedule of Diclofenac PotassiumHStorage Requirements for Diclofenac PotassiumStore Diclofenac potassium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac PotassiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac PotassiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
Home Delivery for Diclofenac Potassium in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including diclofenac potassium.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for diclofenac potassium and other medicines and health products. Home delivery services for diclofenac potassium may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take diclofenac potassium only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for diclofenac potassium before they complete the sale. You can get this information while placing the order for diclofenac potassium with the pharmacy.
Diclofenac Potassium is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac potassium might be better known than diclofenac potassium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac potassium in stock, you can ask for one of the branded alternatives for diclofenac potassium.