Fluorometholone (Eye.Prep.) Pharmacology

Fluorometholone (Eye.Prep.)

About Fluorometholone (Eye.Prep.)
A Synthetic Glucocorticoid, In steroid responsive inflammations of Eye( topical anti-inflammatory).
Mechanism of Action of Fluorometholone (Eye.Prep.)
The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.
The drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) Induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase A2 and thus decreases the production of Prostaglandins, leukotriens (LT), and platelet activating factor, 2) Causes negative regulation of genes for cytokines in macrophages, endothelial cells and lymphocytes and thus decreases the production of interleukins (IL-1, IL-2, IL-3, IL-6), TNF-a, GM-CSF (granulocyte macrophage colony stimulating factor), Gama interferon and suppresses fibroblast proliferation and T-lymphocyte functions and interferes chemo taxis. 3) Decreases the production of acute phase reactants from macrophages and endothelial cells and interferes complement function. 4) Decreases the production of ELAM-1(Endothelial leukocyte adhesion molecule-1) and ICAM-1(intracellular adhesion molecule-1) in endothelial cells. 5) Inhibit IgE mediated histamine and LT-C4 release from basophiles and the effects of antigen-antibody reaction is not mediated 6) Reduces the production of collagenase and stromolysin and thus prevents tissue destruction.
Pharmacokinets of Fluorometholone (Eye.Prep.)
N/A
Onset of Action for Fluorometholone (Eye.Prep.)
N/A
Duration of Action for Fluorometholone (Eye.Prep.)
N/A
Half Life of Fluorometholone (Eye.Prep.)
N/A
Side Effects of Fluorometholone (Eye.Prep.)
1.Elevation of intraocular pressure
2.Optic nerve damage
3.Posterior subcapsular cataract formation
4.Delayed wound healing
5.Acute anterior uveitis
6.Keratitis
7.Conjunctivitis
8.Corneal ulcers
9.Mydriasis
10.Conjunctival hyperemia
11.Loss of accommodation
12.Ptosis
13.Transient burning
14.Stinging
15.Ocular irritation
16.Taste perversion
17.Blurred vision
Contra-indications of Fluorometholone (Eye.Prep.)
1.Hypersensitivity to Fluorometholone
2.Viral and fungal disease of the eye
Special Precautions while taking Fluorometholone (Eye.Prep.)
1.Glaucoma
2.Regular monitoring of intraocular pressure should be required
3.Cataract surgery may delay healing
4.Patient wearing contact lenses
Pregnancy Related Information
Contraindicated
Old Age Related Information
Contraindicated
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Below 2 years: Contraindicated
Indications for Fluorometholone (Eye.Prep.)
Corticosteroid responsive inflammation of eye
Interactions for Fluorometholone (Eye.Prep.)
N/A
Typical Dosage for Fluorometholone (Eye.Prep.)
Instill one drop 2 - 4 times daily. If signs and symptoms fail to improve after two days, the patient should be re-evaluated. The drug should be withdraw gradually.
Schedule of Fluorometholone (Eye.Prep.)
N/A
Storage Requirements for Fluorometholone (Eye.Prep.)
Store at room temperature at 15 - 30 degree Celsius. Avoid freezing. Shake well before use. Keep out of the reach of children.
Effects of Missed Dosage of Fluorometholone (Eye.Prep.)
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule.
Effects of Overdose of Fluorometholone (Eye.Prep.)
Give supportive measures and symptomatic treatment.

Home Delivery for Fluorometholone (Eye.Prep.) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fluorometholone (eye.prep.).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fluorometholone (eye.prep.) and other medicines and health products. Home delivery services for fluorometholone (eye.prep.) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fluorometholone (eye.prep.) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fluorometholone (eye.prep.) before they complete the sale. You can get this information while placing the order for fluorometholone (eye.prep.) with the pharmacy.

Fluorometholone (Eye.Prep.) is a generic medicine name and there are several brands available for it. Some of the brands for fluorometholone (eye.prep.) might be better known than fluorometholone (eye.prep.) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fluorometholone (eye.prep.) in stock, you can ask for one of the branded alternatives for fluorometholone (eye.prep.).