Levobunolol Pharmacology

Levobunolol

About Levobunolol
A non-selective beta blocker, Antiglaucoma(Topical).
Mechanism of Action of Levobunolol
Levobunolol is a non selective beta blocker. It inhibits the beta receptors (?2) present in the eye such as in the ciliary body epithelium and blood vessels. This will leads to decreased aqueous production and reduced intraocular pressure. Aqueous humor production is activated by ? receptor mediated cyclic AMP phosphokinase pathway. Beta receptor blockers will decreases the intracellular cyclic AMP level and reduces intraocular pressure. Another mechanism is that Levobunolol decreases the ocular blood flow which decreases ultrafiltration responsible for aqueous production. It is faster acting than Timolol.
Pharmacokinets of Levobunolol
Absorption: Systemic absorption after instillation in to the eye is minimal. It is metabolised in to pharmacologically active hydro Levobunolol.
Onset of Action for Levobunolol
60 minutes
Duration of Action for Levobunolol
24 hours
Half Life of Levobunolol
N/A
Side Effects of Levobunolol
1.Irritation
2.Burning
3.Tearing
4.Erythema
5.Itching
6.Blepharoconjunctivitis
7.Keratitis
8.Corneal punctuate staining
9.Photophobia
10.Headache
11.Dizziness
12.Reduced heart rate
13.Urticaria
14.Bronchospasm
15. Redness of eyes
16.Hypotension
17.Increased sensitivity of the eyes to light
Contra-indications of Levobunolol
1.Hypersensitivity to Levobunolol
2.Bronchial asthma
3.Chronic obstructive pulmonary diseases
4.Sinus Bradycardia
5.Heart failure
6.Cardiogenic shock
7.AV block (2nd or 3rd degree)
Special Precautions while taking Levobunolol
1.Chronic bronchitis
2.Emphysema
3.Diabetes mellitus
4.Hyperthyroidism
5.Myasthenia gravis
6.Closed angle glaucoma
7.Gradually withdraw the drug in patient with Thyrotoxicosis
8.Cerebrovascular insufficiency
9. Avid use of soft contact lenses.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Levobunolol
1.Chronic open angle glaucoma
2.Ocular hypertension
Interactions for Levobunolol
N/A
Typical Dosage for Levobunolol
Levobunolol 0.25, and 0.5% eye drops are used.
Instill 1-2 drop in to the affected eye for 1 - 2 times daily
Schedule of Levobunolol
N/A
Storage Requirements for Levobunolol
Store at 15 - 30 degree C in a tightly closed light resistant container. Protect from heat and moisture. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Levobunolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Levobunolol
A topical ocular overdose of an ophthalmic product containing Levobunolol may be flushed from the eyes with warm tap water.

Home Delivery for Levobunolol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including levobunolol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levobunolol and other medicines and health products. Home delivery services for levobunolol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levobunolol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levobunolol before they complete the sale. You can get this information while placing the order for levobunolol with the pharmacy.

Levobunolol is a generic medicine name and there are several brands available for it. Some of the brands for levobunolol might be better known than levobunolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levobunolol in stock, you can ask for one of the branded alternatives for levobunolol.