Dipivefrine + Benzalkonium Chloride Pharmacology

Dipivefrine + Benzalkonium Chloride

About Dipivefrine + Benzalkonium Chloride
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Mechanism of Action of Dipivefrine + Benzalkonium Chloride
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Pharmacokinets of Dipivefrine + Benzalkonium Chloride
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Onset of Action for Dipivefrine + Benzalkonium Chloride
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Duration of Action for Dipivefrine + Benzalkonium Chloride
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Half Life of Dipivefrine + Benzalkonium Chloride
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Side Effects of Dipivefrine + Benzalkonium Chloride
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Contra-indications of Dipivefrine + Benzalkonium Chloride
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Special Precautions while taking Dipivefrine + Benzalkonium Chloride
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Dipivefrine + Benzalkonium Chloride
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Interactions for Dipivefrine + Benzalkonium Chloride
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Typical Dosage for Dipivefrine + Benzalkonium Chloride
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Schedule of Dipivefrine + Benzalkonium Chloride
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Storage Requirements for Dipivefrine + Benzalkonium Chloride
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Effects of Missed Dosage of Dipivefrine + Benzalkonium Chloride
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Effects of Overdose of Dipivefrine + Benzalkonium Chloride
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Dipivefrine

About Dipivefrine
Adrenergic Alpha/Beta agonist, prodrug of adrenaline, Ophthalmic Vasoconstrictor, Antiglaucoma ,miotic.
Mechanism of Action of Dipivefrine
Dipivefrine is an ester of Adrenaline and Pivalic acid. It is converted in the eye to active adrenaline. Adrenaline then acts on adrenoceptors in the walls of blood vessels in the eye and produces vasoconstriction and reduces blood flow. This will leads to decreased production of aqueous humor. Adrenaline is also increases the drainage of the fluid from the eye. It opens the drainage channels in the eye and allows fluid to leave the eye and relieves pressure. As adrenaline decreases the amount of fluid inside the eye, it is useful in treating glaucoma.
Pharmacokinets of Dipivefrine
Absorption: Dipivefrine is easily penetrated in to the anterior chamber of the eye.
Onset of Action for Dipivefrine
30 minutes
Duration of Action for Dipivefrine
12 hours
Half Life of Dipivefrine
N/A
Side Effects of Dipivefrine
1 Burning
2.Stinging
3.Conjunctivitis
4.Mydriasis
5.Photophobia
6.Conjunctival hyperemia
7.Arrhythmia
8.Hypertension
9.Tachycardia
Contra-indications of Dipivefrine
1.Hypersensitivity to Dipivefrine, Adrenaline
2.Angle closure glaucoma
Special Precautions while taking Dipivefrine
1.Asthma
2 Aphakia
3.Arrhythmia
4.Avoid use of soft contact lens for minimum of 15 minutes after instillation of drops
5.Do not operate machine or drive vehicle since it produce blurred vision
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Dipivefrine
1.Open angle glaucoma
2.Ocular hypertension
Interactions for Dipivefrine
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Typical Dosage for Dipivefrine
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Schedule of Dipivefrine
N/A
Storage Requirements for Dipivefrine
Store in a cool dry place in a tightly closed container. Protect from heat and light. Keep out of the reach of children. Discard the drug 1 month after opening.
Effects of Missed Dosage of Dipivefrine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dipivefrine
A topical ocular overdose of an ophthalmic product containing Dipivefrine may be flushed from the eye with warm tap water.

Benzalkonium Chloride

About Benzalkonium Chloride
A nitrogenous cationic surfactant, Quaternary ammonium compound, Antiseptic,Disinfectant, A vaginal contraceptive spermicidal agent.
Mechanism of Action of Benzalkonium Chloride
The mechanism of bactericidal/microbicidal action is due to disruption of intermolecular interactions. This cause dissociation of cellular membrane bilayers, which compromises cellular permeability controls and induces leakage of cellular contents. Other biomolecular complexes within the bacterial cell can also undergo dissociation. It also inactivates the enzyme produced by different microorganisms. It also has spermicidal action. They work by damaging and killing sperm in the vagina. Therefore, the sperm are not able to travel from the vagina into the uterus and fallopian tubes, where fertilization usually takes place.
Pharmacokinets of Benzalkonium Chloride
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Onset of Action for Benzalkonium Chloride
N/A
Duration of Action for Benzalkonium Chloride
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Half Life of Benzalkonium Chloride
N/A
Side Effects of Benzalkonium Chloride
1. Chills
2. Confusion
3. Dizziness
4. Fever
5. Lightheadedness
6. Muscle aches
7. Sunburn-like skin rash
8. Cloudy or bloody urine
9. Increased frequency of urination
10. Pain in the bladder or lower abdomen
11. Pain on urination; thick
12. White or curd-like vaginal discharge-with use of cervical caps or diaphragms
13. Vaginal dryness
14. Odor
Contra-indications of Benzalkonium Chloride
1. Hypersensitivity to the drug
2. Allergies, irritations, or infections of the genitals
3. Recent abortion
4. Sores on the genitals (sex organs)
5. Irritation of the vagina
Special Precautions while taking Benzalkonium Chloride
Discontinue use if you have abnormal discharge or vaginal burning or itching.
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Benzalkonium Chloride
1. Antisepsis of skin, mucous membranes, and wounds.
2. Preoperative preparation of the skin, surgeons` hand and arm soaks
3. Treatment of wounds
4. Preservation of ophthalmic solutions
5. Irrigations of the eye, body cavities, bladder, urethra
6. Vaginal douching.
7. Contraceptives
Interactions for Benzalkonium Chloride
N/A
Typical Dosage for Benzalkonium Chloride
Vaginal suppositories dosage form (preventing pregnancy):
Adults and teenagers-
For use alone: One suppository inserted into the vagina at least ten minutes but not longer than four hours before each time you have sexual intercourse.
With a diaphragm: After the diaphragm with spermicide has been placed into the vagina, insert one suppository at least ten minutes, but not longer than four hours, before each time you have sexual intercourse. Also, insert another suppository before sexual intercourse if six hours have passed since you inserted the diaphragm
Schedule of Benzalkonium Chloride
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Storage Requirements for Benzalkonium Chloride
Store at controlled room temperature, away from light and excessive heat. Keep out of reach of children.
Effects of Missed Dosage of Benzalkonium Chloride
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Benzalkonium Chloride
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Home Delivery for Dipivefrine + Benzalkonium Chloride in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dipivefrine + benzalkonium chloride and other medicines and health products. Home delivery services for dipivefrine + benzalkonium chloride may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dipivefrine + benzalkonium chloride only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dipivefrine + benzalkonium chloride before they complete the sale. You can get this information while placing the order for dipivefrine + benzalkonium chloride with the pharmacy.

Dipivefrine + Benzalkonium Chloride is a generic medicine name and there are several brands available for it. Some of the brands for dipivefrine + benzalkonium chloride might be better known than dipivefrine + benzalkonium chloride itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dipivefrine + benzalkonium chloride in stock, you can ask for one of the branded alternatives for dipivefrine + benzalkonium chloride.