Dorzolamide Pharmacology


About Dorzolamide
Carbonic anhydrase inhibitor, Thiophene derivative, a sulfonamide, Antiglucoma.
Mechanism of Action of Dorzolamide
Dorzolamide is a sulfonamide used as topical carbonic anhydrase inhibitor. Inhibition of carbonic anhydrase-2 in ciliary processes of eye leads to reducing intra ocular tension by decreasing aqueous humor secretion by slowing the formation of bicarbonate ions with subsequent decrease in sodium and fluid transport.
Pharmacokinets of Dorzolamide
After topical administration drug reaches systemic circulation.
Distribution: It preferentially binds to carbonic anhydrase of red blood cells and about 33% of drug is protein bound.
Metabolism: Metabolized in to N-ethyl Dorzolamide.
Excretion: Excreted mainly through urine as unchanged drug as well as metabolite.
Onset of Action for Dorzolamide
Duration of Action for Dorzolamide
Half Life of Dorzolamide
4 months
Side Effects of Dorzolamide
1. Bitter taste
2. Ocular burning and stinging
3. Conjunctivitis
4. Eye lid irritations
5. Nausea
6. Fatigue
7. Blurred vision
8. Lacrimation
9. Paresthesia
10. Urolithiasis
11. Dizziness
12. Corneal Oedema
13. Hypersensitivity reactions
14. Rhinitis
15. Sinusitis
16. Asthenia
17. Epistaxis
18. Angioedema
19. Ototoxicity
Contra-indications of Dorzolamide
1. Hypersensitivity to the drug
2. Renal impairment
3. Hyperchloremic acidosis

Special Precautions while taking Dorzolamide
1. Hepatic impairment
2. Avoid use together with other carbonic anhydrase inhibitors
3. Discontinue the drug in hypersensitivity reactions
4. Stop the drug in corneal oedema, conjunctivitis, and eye lid reactions
5. Intraocular surgery
6. Corneal defects
7. Urolithiasis
Pregnancy Related Information
Old Age Related Information
Use with caution
Breast Feeding Related Information
Children Related Information
Indications for Dorzolamide
1. Ocular hypertension
2. Open angle glaucoma
Interactions for Dorzolamide
Similar to diuretics (carbonic anhydrase inhibitor) ? as possibility of systemic absorption after topical administration.
Typical Dosage for Dorzolamide
One drop of 2% solution three times daily.
Schedule of Dorzolamide
Storage Requirements for Dorzolamide
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Dorzolamide
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dorzolamide
Treatment is supportive and symptomatic. Monitor and support fluid and electrolyte balance. Correct blood acidotic state.

Home Delivery for Dorzolamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dorzolamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dorzolamide and other medicines and health products. Home delivery services for dorzolamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dorzolamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dorzolamide before they complete the sale. You can get this information while placing the order for dorzolamide with the pharmacy.

Dorzolamide is a generic medicine name and there are several brands available for it. Some of the brands for dorzolamide might be better known than dorzolamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dorzolamide in stock, you can ask for one of the branded alternatives for dorzolamide.