Aceclofenac + Serratiopeptidase Pharmacology

Aceclofenac + Serratiopeptidase

About Aceclofenac + Serratiopeptidase
N/A
Mechanism of Action of Aceclofenac + Serratiopeptidase
N/A
Pharmacokinets of Aceclofenac + Serratiopeptidase
N/A
Onset of Action for Aceclofenac + Serratiopeptidase
N/A
Duration of Action for Aceclofenac + Serratiopeptidase
N/A
Half Life of Aceclofenac + Serratiopeptidase
N/A
Side Effects of Aceclofenac + Serratiopeptidase
N/A
Contra-indications of Aceclofenac + Serratiopeptidase
N/A
Special Precautions while taking Aceclofenac + Serratiopeptidase
N/A
Pregnancy Related Information
Contraindicated; Aceclofenac and Serratiopeptidase are contraindicated in pregnancy. So the combination generic is contraindicated in pregnancy
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated; Aceclofenac and Serratiopeptidase are contraindicated in breast feeding. So the combination generic is contraindicated in breast feeding mother.
Children Related Information
N/A
Indications for Aceclofenac + Serratiopeptidase
1.Painful muscle spasm
Interactions for Aceclofenac + Serratiopeptidase
N/A
Typical Dosage for Aceclofenac + Serratiopeptidase
1 tablet to be taken 3 times daily
Schedule of Aceclofenac + Serratiopeptidase
N/A
Storage Requirements for Aceclofenac + Serratiopeptidase
N/A
Effects of Missed Dosage of Aceclofenac + Serratiopeptidase
N/A
Effects of Overdose of Aceclofenac + Serratiopeptidase
N/A

Aceclofenac

About Aceclofenac
NSAID, Analgesic, Antiinflammatory, Anti arthritic.
Mechanism of Action of Aceclofenac
This drug has several mechanism of action.
1. It inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action).
2. It blocks degeneration and stimulates synthesis of extra cellular matrix of cartilages by inhibiting the action of different cytokines.
3. Drug and its metabolites inhibit IL-6 production by human chondrocytes. This leads to inhibition of increase of inflammatory cells in synovial tissue, inhibition of IL-1 amplification, inhibition of increased MMP synthesis and thus ensuring proteoglycan production.
4. It inhibits IL-1 and TNF production by human chondrocytes, inflammatory cells and synovial cells and therefore blocks suppression of GAG and collagen synthesis and stimulates growth factors mediated synthesis of GAG and collagen.
5. 4`-hydroxyaceclofenac a metabolite of aceclofenac inhibits pro MMP1 and pro MMP3 produced by synovial cells (Rheumatoid Synovial Cells) in serum and in synovial fluid and thus inhibits progressive joint destruction by MMPs.
6. Aceclofenac inhibits Neutrophil Adhesion & Accumulation at the inflammatory site in the early phase and thus blocks the pro-inflammatory actions of Neutrophils.
7. Aceclofenac is also an NSAID with greater COX-2 specificity
Pharmacokinets of Aceclofenac
Absorption- It is rapidly and completely absorbed after oral administration
Distribution- Widely distributed in the body as protein-bound form. It is highly protein-bound (>99.7%). Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 60% of those in plasma.
Metabolism- Metabolized into metabolites in the liver. Main metabolite is 4-hydroxyaceclofenac
Excretion- It is excreted through urine mainly as conjugated hydroxymetabolites
Onset of Action for Aceclofenac
N/A
Duration of Action for Aceclofenac
N/A
Half Life of Aceclofenac
The mean plasma elimination half-life is 4 - 4.3 hours
Side Effects of Aceclofenac
1. Dyspepsia
2. Abdominal pain
3. Dizziness
4. Vertigo
5. Pruritis
6. Rash
7. Dermatitis
8. Nausea
9. Diarrhoea
10. Flatulence
11. Gastritis
12. Constipation
13. Vomiting
14. Ulcerative stomatitis
15. Elevation of circulating levels of hepatic enzymes.
Contra-indications of Aceclofenac
1. Hypersensitivity to the drug
2. Bleeding from the stomach or intestines
3. Moderate to severely decreased kidney function
4. Hypersensitivity to other NSAIDs
5. Active peptic ulcer
Special Precautions while taking Aceclofenac
1. Hepatic porphyria
2. Bleeding tendencies
3. Blood disorders
4. Crohn`s disease
5. Decreased heart function
6. History of peptic ulcers
7. Inflammation of the bowel and back passage
8. Mildly decreased kidney function
9. Recent major surgery
10. Stomach disorders
11. Decreased liver function
12. Intestinal disorders
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution
Indications for Aceclofenac
1. Ankylosing spondylitis
2. Osteoarthritis
3. Symptomatic treatment of pain and inflammation in Post-Traumatic pain
4. Cervical pain
5. Low back pain
6. Acute gout
Interactions for Aceclofenac
Lithium, digoxin and methotrexate: Aceclofenac may increase plasma concentrations of lithium, digoxin and methotrexate.
Anticoagulants: Activity of anticoagulants may be increased.
Diuretics : Aceclofenac inhibits the activity of diuretics. When concomitantly administrated with potassium sparing diuretics, serum potassium should be monitored.
Cyclosporin: Aceclofenac may enhance cyclosporin nephrotoxicity.
Quinolones : Aceclofenac may precipitate convulsions when coadministered with quinolone antibiotics.
Typical Dosage for Aceclofenac
Oral-
Adult (general dose)-
100mg twice daily
Schedule of Aceclofenac
H
Storage Requirements for Aceclofenac
Store below 25?C
Effects of Missed Dosage of Aceclofenac
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Aceclofenac
Give symptomatic and supportive treatment. Induce gastric lavage and administer charcoal in repeated doses. Treated with antacid if necessary.

Serratiopeptidase

About Serratiopeptidase
A proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.
Mechanism of Action of Serratiopeptidase
This anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.
Pharmacokinets of Serratiopeptidase
Orally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.
Onset of Action for Serratiopeptidase
N/A
Duration of Action for Serratiopeptidase
8 to 10 hrs
Half Life of Serratiopeptidase
N/A
Side Effects of Serratiopeptidase
1. Hypersensitivity
2. Anorexia
3. Gastric discomfort
4. Nausea
5. Vomiting
6. Epistaxis
7. Diarrhoea
8. Skin rash
Contra-indications of Serratiopeptidase
1. Hypersensitivity to this drug
2. Blood coagulation disorder
Special Precautions while taking Serratiopeptidase
1. In patients with renal failure or hepatic failure
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
Contraindicated
Children Related Information
N/A
Indications for Serratiopeptidase
1. Antiinflammatory
2. Antiswelling
3. Anti- rheumatoid
4. To promote transfer of antibiotics to the site of action
5. To promote lysis and discharge of sputum and pus
6. Bronchitis
7. Fibrocystic breast swelling
8. Sinusitis
9. Cough
10. Laryngitis
11. Fibromyalgia
12. Emphysema
13. Gout
Interactions for Serratiopeptidase
N/A
Typical Dosage for Serratiopeptidase
Oral-
Adults-5 to 10mg tab every 3 times daily.
10- 30 mg tab /day.
Schedule of Serratiopeptidase
N/A
Storage Requirements for Serratiopeptidase
Store below 25 degree Celsius, protect from light and moisture.
Effects of Missed Dosage of Serratiopeptidase
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Serratiopeptidase
Give supportive measures and symptomatic treatment.

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