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- Pharmacology For Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleate
Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleate Pharmacology
Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleate
About Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AMechanism of Action of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/APharmacokinets of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AOnset of Action for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/ADuration of Action for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AHalf Life of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/ASide Effects of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AContra-indications of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/ASpecial Precautions while taking Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AInteractions for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/ATypical Dosage for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/ASchedule of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AStorage Requirements for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AEffects of Missed Dosage of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/AEffects of Overdose of Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleateN/APhenylephrine
About PhenylephrineAn a1-adrenergic receptor agonist, Phenethylamine derivative, Decongestant, Antiglaucoma, Mydriatic.Mechanism of Action of PhenylephrineThe drug exerts it`s pharmacological action by acting as a selective alpha-1 adrenergic agonist. It causes vasoconstriction and increases total peripheral resistance and raises blood pressure. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It exerts nasal decongestant action; by vasoconstrictory action on arterioles of nasal mucosa. It prolongs and localizes the action of anaesthetics due to it`s vasoconstrictory action on skin, mucous membrane, and viscera and thus slows the rate of absorption of local anaesthetics.Pharmacokinets of PhenylephrineAbsorption: Variable depending up on the route of administration. Metabolism: Metabolized in the liver and intestine.Onset of Action for PhenylephrineNasal: Rapid
Ophthalmic: Rapid
I.V.: Rapid
I.M.: Within 15 minutes
Duration of Action for PhenylephrineNasal: ? to 4 hours
Ophthalmic: 3 to 7 hours
I.V.: 15 to 20 minutes
I.M.: ? to 2 hours.
Half Life of PhenylephrineN/ASide Effects of Phenylephrine1.Bradycardia
2.Arrhythmias
3.Hypertension
4.Tachycardia
5.Palpitations
6.Premature ventricular contractions
7.Pallor
8.Headache
9.Dizziness
10.Nervousness
11.Brow ache(with ophthalmic form)
12.Burning or stinging in eye
13.Blurred vision
14.Elevated intraocular pressure
15.Nausea
16.Episodes of asthma
17.Tachyphylaxis
18.Anaphylaxis
Contra-indications of Phenylephrine1.Hypersensitivity to the drug
2.Hyperthyroidism
3.Ventricular tachycardia and severe hypertension (Injected form)
4.Angle closure glaucoma and in those who wear soft contact lenses(ophthalmic form)
Special Precautions while taking Phenylephrine1.Coronary diseases
2.Advanced arteriosclerosis
3.Bradycardia
4.Partial heart block
5.Myocardial diseases
6.Atherosclerosis
7.Hypertension
8.Nasal and ophthalmic form use cautiously in type-1 diabetes mellitus
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Below age 6:contraindicatedIndications for Phenylephrine1.Hypotension
2.Paroxysmal supra ventricular tachycardia
3.Maintain blood pressure during spinal and inhalation anaesthesia
4.Prolongation of spinal anaesthesia
5.Shock
6.Mydriasis(without cycloplegia)
7.Nasal congestion.
8.Cataract
Interactions for PhenylephrineMay interact with systemically administered MAOIs.Typical Dosage for PhenylephrineI.M. or S.C.: 2 to 5mg. Then if required; give doses up to 10mg.
Slow I.V. injection: 0.1 to 0.5mg. Then if required; repeat after 15 minutes.
I.V. infusion: Starts with 0.18mg/minute. Then adjust the dosage up to 0.03 to 0.06mg/minute based on patient`s response.
Nasal congestion: Apply 2 to 3 drops or 1 to 2 sprays of 0.25% to 1% solution instilled in each nostril.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Prolongation of spinal anaesthesia: 2 to 5mg added to anaesthetic solution.
Schedule of PhenylephrineN/AStorage Requirements for PhenylephrineStore at controlled room temperature at range of 15 to 30 degree C. in a well closed container. Protect from light.Effects of Missed Dosage of PhenylephrineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylephrineDiscontinue the drug and give supportive and symptomatic treatment. Closely monitor vital signs. Use atropine sulfate to block reflex Bradycardia. Treat excessive hypertension with phentolamine. Treat cardiac arrhythmia with propranolol. Treat excessive mydriatic effect with levodopa.
Naphazoline (Eye Pre.)
About Naphazoline (Eye Pre.)Imidazoline derivative,Alpha-adrenergic agonist, A decongestant in eye allergies.Mechanism of Action of Naphazoline (Eye Pre.)The drug exerts its pharmacological action by acting as a selective alpha-1 adrenergic agonist. It reduces intraocular tension by constricting ciliary body blood vessels and produce mydriasis (without cycloplegia). It shrinks swollen blood vessels in the congested or red eye and in this way gets rid of the redness and whitens the eye.Pharmacokinets of Naphazoline (Eye Pre.)N/AOnset of Action for Naphazoline (Eye Pre.)RapidDuration of Action for Naphazoline (Eye Pre.)3 to 7 hoursHalf Life of Naphazoline (Eye Pre.)N/ASide Effects of Naphazoline (Eye Pre.)1.Brow ache
2.Burning or stinging in eye
3.Blurred vision
4.Elevated intraocular pressure
5.Photophobia
6.Lacrimation
Contra-indications of Naphazoline (Eye Pre.)1. Hypersensitivity to the drug or any ingredients of it
2. Acute angle closure glaucoma
Special Precautions while taking Naphazoline (Eye Pre.)1.Type-1 diabetes mellitusPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Naphazoline (Eye Pre.)1.Ocular congestion
2.Irritation and Itching of the eye
Interactions for Naphazoline (Eye Pre.)N/ATypical Dosage for Naphazoline (Eye Pre.)Adults-
1 to 2 drops (0.1%) every 3 to 4 hrs or 1 to 2 drops/day (0.012% to 0.03%) for 3 to 4 days.
Mydriasis (without cycloplegia): Instill 1 to 2drops 2.5% or 10% solution in eye. Repeated if required.
Schedule of Naphazoline (Eye Pre.)N/AStorage Requirements for Naphazoline (Eye Pre.)Store at room temperature in a tightly closed container. Keep away from children.Effects of Missed Dosage of Naphazoline (Eye Pre.)Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Naphazoline (Eye Pre.)Provide supportive measures and symptomatic treatment. Chlorpheniramine Maleate
About Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/AHome Delivery for Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleate in Your City
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Phenylephrine + Naphazoline (Eye Pre.) + Chlorpheniramine maleate is a generic medicine name and there are several brands available for it. Some of the brands for phenylephrine + naphazoline (eye pre.) + chlorpheniramine maleate might be better known than phenylephrine + naphazoline (eye pre.) + chlorpheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phenylephrine + naphazoline (eye pre.) + chlorpheniramine maleate in stock, you can ask for one of the branded alternatives for phenylephrine + naphazoline (eye pre.) + chlorpheniramine maleate.
