Sodium Hyaluronate Pharmacology

Sodium Hyaluronate

About Sodium Hyaluronate
A visco-elastic polymer(Glycosaminoglycan), A tissue lubricant(prevent vaginal dryness),in osteoarthritis.
Mechanism of Action of Sodium Hyaluronate
Sodium hyaluronate is a sterile, nonpyrogenic, highly purified, noninflammatory, high molecular weight viscoelastic preparation. It is a physiological substance that is widely distributed in the extracellular matrix of connective tissues in both animals and man. It is present in the vitreous and aqueous humor of the eye, the synovial fluid, the skin and the umbilical cord. Sodium hyaluronate is a polysaccharide made up of disaccharide units linked by glycosidic bonds.
Sodium hyaluronate occurs naturally on the corneal endothelium, bound to specific receptors. The natural sodium hyaluronate layer on the corneal endothelium is reduced during irrigation, but can be restored by exogenous sodium hyaluronate. It has high affinity to the receptors and act as scavengers by neutralizing the free radicals formed during cataract surgery using ultrasound. Sodium hyaluronate protects corneal endothelial cells and other ocular structures. It does not interfere with epithelialization and normal wound healing.
Sodium hyaluronate is also used as an ingredient in local vaginal preparations to moisturize vagina and prevent vaginal dryness
Pharmacokinets of Sodium Hyaluronate
Sodium hyaluronate is rapidly eliminated by metabolism
Onset of Action for Sodium Hyaluronate
Duration of Action for Sodium Hyaluronate
Half Life of Sodium Hyaluronate
Side Effects of Sodium Hyaluronate
1. Transient rise in intraocular pressure
2. Postoperative, inflammatory reactions (iritis, hypopyon)
3. Corneal edema
Contra-indications of Sodium Hyaluronate
No contraindications
Special Precautions while taking Sodium Hyaluronate
1. Do not overfill the eye with sodium hyaluronate (except in glaucoma surgery).
2. Remove some of the sodium hyaluronate by irrigation and/or aspiration at the close of surgery.
3. Carefully monitor intraocular pressure, especially during the immediate postoperative period. If significant rises are observed, treat with appropriate therapy.
4. When air is used in conjunction with sodium hyaluronate, care should be taken to avoid trapping the air behind the iris
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Indications for Sodium Hyaluronate
Surgical procedures in the anterior chamber of the eye
1. Intra- and extra capsular cataract surgery
2. Intraocular lens (IOL) implantation
3. Keratoplasty
4. Glaucoma surgery
5. Post-trauma surgery
6. Vitreous replacement after vitrectomy and retinal detachment surgery
7. Corneal transplant surgery
8. Glaucoma filtration
9. Trauma surgery
10. Vaginal dryness
11. Dyspareunia

Interactions for Sodium Hyaluronate
Typical Dosage for Sodium Hyaluronate
Adult: The total amount introduced through repeated injections is usually less than 1 ml.
Cataract Surgery: A sufficient amount of sodium hyaluronate is slowly and carefully introduced into the anterior chamber to replace the aqueous humor before any instrument is introduced into the eye. Filling the anterior chamber and the capsular bag facilitates in-the-bag implantation. Additional sodium hyaluronate can be injected during surgery to replace any sodium hyaluronate lost during surgical manipulation
Glaucoma Filtration Surgery: In trabeculectomy, sodium hyaluronate is injected slowly and carefully through a corneal paracentesis to reconstitute the anterior chamber. Further injection can be continued to allow it to extrude into the subconjunctival filtration site through and around the sutured outer scleral flap.
Corneal Transplant Surgery: During trepanation of the cornea, the anterior chamber is filled with sodium hyaluronate. The donor graft can then be placed on top of the bed of sodium hyaluronate and sutured in place. Additional drops may be injected to replace any sodium hyaluronate lost as a result of surgical manipulation.

Trauma: It is injected to reform the anterior chamber, to manoeuvre, protect and support ocular tissues and to create space for surgical instruments during reconstructive surgery.

Schedule of Sodium Hyaluronate
Storage Requirements for Sodium Hyaluronate
Store in 2-8 degree C. Protect from freezing. Protect from light. It should be allowed to attain room temperature (approximately 30 minutes) prior to use.
Effects of Missed Dosage of Sodium Hyaluronate
Effects of Overdose of Sodium Hyaluronate
Give supportive measures and symptomatic treatment.

Home Delivery for Sodium Hyaluronate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including sodium hyaluronate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for sodium hyaluronate and other medicines and health products. Home delivery services for sodium hyaluronate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take sodium hyaluronate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for sodium hyaluronate before they complete the sale. You can get this information while placing the order for sodium hyaluronate with the pharmacy.

Sodium Hyaluronate is a generic medicine name and there are several brands available for it. Some of the brands for sodium hyaluronate might be better known than sodium hyaluronate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have sodium hyaluronate in stock, you can ask for one of the branded alternatives for sodium hyaluronate.