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- Pharmacology For Diclofenac Sodium + Rabeprazole
Diclofenac Sodium + Rabeprazole Pharmacology
Diclofenac Sodium + Rabeprazole
About Diclofenac Sodium + RabeprazoleN/AMechanism of Action of Diclofenac Sodium + RabeprazoleN/APharmacokinets of Diclofenac Sodium + RabeprazoleN/AOnset of Action for Diclofenac Sodium + RabeprazoleN/ADuration of Action for Diclofenac Sodium + RabeprazoleN/AHalf Life of Diclofenac Sodium + RabeprazoleN/ASide Effects of Diclofenac Sodium + RabeprazoleN/AContra-indications of Diclofenac Sodium + RabeprazoleN/ASpecial Precautions while taking Diclofenac Sodium + RabeprazoleN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Diclofenac Sodium + RabeprazoleN/AInteractions for Diclofenac Sodium + RabeprazoleN/ATypical Dosage for Diclofenac Sodium + RabeprazoleN/ASchedule of Diclofenac Sodium + RabeprazoleN/AStorage Requirements for Diclofenac Sodium + RabeprazoleN/AEffects of Missed Dosage of Diclofenac Sodium + RabeprazoleN/AEffects of Overdose of Diclofenac Sodium + RabeprazoleN/ADiclofenac Sodium
About Diclofenac SodiumN/AMechanism of Action of Diclofenac SodiumDiclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .Pharmacokinets of Diclofenac SodiumAbsorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.Onset of Action for Diclofenac Sodium1- 4.5 hoursDuration of Action for Diclofenac SodiumHoursHalf Life of Diclofenac Sodium2 hoursSide Effects of Diclofenac Sodium1.Nausea
2.Vomiting
3.Anorexia
4.Diarrhoea
5.Gastrointestinal bleeding
6.Abdominal distress
7.Constipation
8.Flatulence
9.Ulceration of the stomach or intestine
10.Dyspepsia
11.Headache
12.Dizziness
13. Rash
Contra-indications of Diclofenac Sodium1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
2.Peptic ulcer
3.Asthma
Special Precautions while taking Diclofenac Sodium1.Hepatic impairment
2.Renal impairment
3.Hypertension
4.Blood clotting disorders
5.Gastrointestinal diseases
6.Proctitis
7.Asthma
8.Cautioned against driving, operating or activities requiring concentration
9.Avoid alcohol
10.Heart failure
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with caution
CHILDREN below 14: contraindicatedIndications for Diclofenac Sodium1.Ankylosing spondylitis
2.Acute gout
3.Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
4.Osteoarthritis
5.For the relief of pain and inflammation in dental minor surgery and orthopedic
6.Dysmenorrhoea
7.Juvenile chronic arthritis
8.Migraine
Interactions for Diclofenac SodiumLithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
Methotrexate : Toxicity enhanced.
Salicylates : Efficacy of salicylates reduced.
Cyclosporine : Increases nephrotoxicity of both agents.
Hydantoins : Increases serum levels resulting in toxicity.
Typical Dosage for Diclofenac SodiumAdult: 100 - 150 mg / day in 2 - 3 divided doses.
For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
Osteoarthritis: 50 mg 2 - 3 times daily
Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
Maximum dose: 3 mg / kg body weight / day in divided doses
Schedule of Diclofenac SodiumHStorage Requirements for Diclofenac SodiumStore Diclofenac sodium at room temperature in a tightly closed light resistant container.Effects of Missed Dosage of Diclofenac SodiumTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Diclofenac SodiumGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.Rabeprazole
About RabeprazoleBenzimidazole derivative, Proton Pump Inhibitor, Antiulcer.Mechanism of Action of RabeprazoleRabeprazole sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.Pharmacokinets of RabeprazoleAbsorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Rabeprazole sodium is extensively metabolised in the liver. Excretion: It is excreted mainly in the urine and small amount in faeces.Onset of Action for Rabeprazole1hourDuration of Action for Rabeprazole1 dayHalf Life of Rabeprazole1 - 2 hoursSide Effects of Rabeprazole1. Diarrhoea
2. Nausea
3. Headache
4. Vomiting
5. Abdominal pain
6. Dizziness
7. Flatulence
8. Constipation
9. Dyspepsia
10. Flu like syndrome
11. Insomnia
12. Back pain
13. Cough
14. Rhinitis
15. Pharyngitis
16. Rash
Contra-indications of Rabeprazole1. Hypersensitivity to Rabeprazole sodiumSpecial Precautions while taking Rabeprazole1. Hepatic impairment
2. Monitor gastric malignancy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for Rabeprazole1. Active Duodenal ulcer
2. Benign Gastric ulcer
3. Zollinger- Ellison syndrome
4. Erosive Gastroesophageal reflux disease
Interactions for RabeprazoleKetoconazole : Coadministration of rabeprazole sodium results in a 33% decrease in ketoconazole levels.
Digoxin : Increase in trough digoxin levels in normal subjects.
Typical Dosage for RabeprazoleOral
Adult: 10 - 20 mg / day drug to be taken before breakfast.
Duodenal ulcer: 20 mg / day in the morning for 1 month if needed dose can be continuing for 1more month.
Benign Gastric ulcer: 20 mg / day in the morning for 6 weeks if needed dose can be continuing for 6 more weeks.
Zollinger- Ellison syndrome: Initial dose: 60 mg / day if needed increase the dose up to 120 mg / day in 2 divided doses.
Erosive Gastroesophageal reflux disease: 20mg / day for 1-2 months.
Gastroesophageal reflux disease long term management: 10-20 mg once daily before breakfast for 1 year
Children: not recommended
Schedule of RabeprazoleHStorage Requirements for RabeprazoleStore at 15 - 30 degree C in a tightly closed container. Protect from light.Effects of Missed Dosage of RabeprazoleTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of RabeprazoleGive supportive measures and symptomatic treatment.Home Delivery for Diclofenac Sodium + Rabeprazole in Your City
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Diclofenac Sodium + Rabeprazole is a generic medicine name and there are several brands available for it. Some of the brands for diclofenac sodium + rabeprazole might be better known than diclofenac sodium + rabeprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have diclofenac sodium + rabeprazole in stock, you can ask for one of the branded alternatives for diclofenac sodium + rabeprazole.
