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- Pharmacology For Glycolic acid + Vitamin A
Glycolic acid + Vitamin A Pharmacology
Glycolic acid + Vitamin AAbout Glycolic acid + Vitamin AN/AMechanism of Action of Glycolic acid + Vitamin AN/APharmacokinets of Glycolic acid + Vitamin AN/AOnset of Action for Glycolic acid + Vitamin AN/ADuration of Action for Glycolic acid + Vitamin AN/AHalf Life of Glycolic acid + Vitamin AN/ASide Effects of Glycolic acid + Vitamin AN/AContra-indications of Glycolic acid + Vitamin AN/ASpecial Precautions while taking Glycolic acid + Vitamin AN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Glycolic acid + Vitamin AN/AInteractions for Glycolic acid + Vitamin AN/ATypical Dosage for Glycolic acid + Vitamin AN/ASchedule of Glycolic acid + Vitamin AN/AStorage Requirements for Glycolic acid + Vitamin AN/AEffects of Missed Dosage of Glycolic acid + Vitamin AN/AEffects of Overdose of Glycolic acid + Vitamin AN/A
Glycolic acidAbout Glycolic acidHydroxy acid derivative, Keratolytic(Ani acne), Preservative.Mechanism of Action of Glycolic acidGlycolic acid works like an exfoliant. Through removal of dead skin cells that have been aggregated on the skins surface area. The composition of these dead cells emphasizes fine lines and pores or other skin impairments .Once applied, glycolic acid reacts with the upper layer of the epidermis, weakening the binding properties of the lipids that hold the dead skin cells together. This allows the stratum corneum to be exfoliated, exposing live skin cells.Pharmacokinets of Glycolic acidN/AOnset of Action for Glycolic acidN/ADuration of Action for Glycolic acidN/AHalf Life of Glycolic acidN/ASide Effects of Glycolic acidN/AContra-indications of Glycolic acidN/ASpecial Precautions while taking Glycolic acidN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Glycolic acid1.Melasma (Dark skin discoloration)
10.Milia (Milk spots)
11.Sun damaged skin
Interactions for Glycolic acidN/ATypical Dosage for Glycolic acidN/ASchedule of Glycolic acidN/AStorage Requirements for Glycolic acidN/AEffects of Missed Dosage of Glycolic acidN/AEffects of Overdose of Glycolic acidN/A
Vitamin AAbout Vitamin AFat-soluble vitamin, Treatment of vitamin A deficiency.Mechanism of Action of Vitamin AVitamin A is required for a variety of physiological functions in the body such as: - 1).Proper functioning of retina and formation of pigment Rhodopsin during dark adaptation. 2).promotes differentiation and maintains structural integrity of epithelia over the body and also retard the malignancies of epithelial structures.3).Promotes mucous secretion. 4).Inhibits keratinization, 5). Maintains proper bone growth, 6).Maintenance of spermatogenesis, 7).Supports foetal development, 8).Improves resistance to infection. It is required for proper antibody response, normal lymphocyte proliferation and killer cell function.Pharmacokinets of Vitamin AAbsorption: Completely absorbed normally. Steatorrhoea, bile deficiency, and protein poor diet adversely affects the absorption and absorption requires bile salts, pancreatic lipase, and dietary fat.
Distribution: Stored primarily as palmitate in kupffer`s cells in liver. Circulates in the form of specific alpha-1 protein; retinol binding protein and transported to cellular retinol binding protein of target cells.
Metabolism: Metabolized in the liver.
Excretion: Excreted mainly through bile and a small amount is excreted through urine.
Onset of Action for Vitamin AN/ADuration of Action for Vitamin AN/AHalf Life of Vitamin AN/ASide Effects of Vitamin AAdverse effects occurs only with higher doses and toxicity
7. Bone and joint pain
10. Increased intracranial pressure
11. Hepatic impairment
12. Anaphylactic shock
Contra-indications of Vitamin A1. Hypervitaminosis A
2. Hypersensitivity to the vitamin A
Special Precautions while taking Vitamin A1. Oral form should not use in patients with malabsorption syndrome.
2. In inadequate bile secretion oral route may be used with concurrent administration of bile salts.
3. I. V. route is contraindicated except for special water miscible forms intended for infusion with large parenteral volumes and should not use I. V. push of vitamin A of any type.
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Vitamin A1. Vitamin A deficiency
5. Bitot`s spots
6. Night blindness
Interactions for Vitamin ACholestyramine: Absorption of Vitamin A is reduced due to reduced availability of fat stabilizing bile salts.
Mineral oil: Interferes with intestinal absorption of Vitamin A.
Oral Contraceptives: Plasma Vitamin A levels are significantly increased.Typical Dosage for Vitamin ASevere vitamin A deficiency with xerophthalmia: 500000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Severe vitamin A deficiency: 100000 IU daily for 3 days followed by 50000 IU daily for 14 days. Then maintenance dosage of 10000 to 20000 IU for 2months followed by adequate dietary nutrition and RDA vitamin A supplements.
Children: 5000 to 10000 IU daily for 14 days.
Schedule of Vitamin AC1 (Oral)
Storage Requirements for Vitamin AStore in a well closed, airtight container in a cool dry place.Effects of Missed Dosage of Vitamin ATake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Vitamin ADiscontinue the vitamin A if hypercalcaemia persists and administer I.V. saline, prednisolone, and calcitonin if required. Monitor hepatic function tests to detect liver damage.
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