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- Pharmacology For Calamine + Diphenhydramine + Camphor
Calamine + Diphenhydramine + Camphor Pharmacology
Calamine + Diphenhydramine + CamphorAbout Calamine + Diphenhydramine + CamphorN/AMechanism of Action of Calamine + Diphenhydramine + CamphorN/APharmacokinets of Calamine + Diphenhydramine + CamphorN/AOnset of Action for Calamine + Diphenhydramine + CamphorN/ADuration of Action for Calamine + Diphenhydramine + CamphorN/AHalf Life of Calamine + Diphenhydramine + CamphorN/ASide Effects of Calamine + Diphenhydramine + CamphorN/AContra-indications of Calamine + Diphenhydramine + CamphorN/ASpecial Precautions while taking Calamine + Diphenhydramine + CamphorN/APregnancy Related InformationMay be used; it is an external preparation and is not absorbed in to systemic circulation.Old Age Related InformationN/ABreast Feeding Related InformationMay be used; it is an external preparation and is not absorbed in to systemic circulation.Children Related InformationN/AIndications for Calamine + Diphenhydramine + CamphorDiphenhydramine provides local antihistaminic action while calamine has a soothing effect on irritated skin.
1.Irritations due to insect bites and stings
Interactions for Calamine + Diphenhydramine + CamphorN/ATypical Dosage for Calamine + Diphenhydramine + CamphorIt should be applied 2 or 3 times daily to the affected areasSchedule of Calamine + Diphenhydramine + CamphorN/AStorage Requirements for Calamine + Diphenhydramine + CamphorN/AEffects of Missed Dosage of Calamine + Diphenhydramine + CamphorN/AEffects of Overdose of Calamine + Diphenhydramine + CamphorN/A
CalamineAbout CalamineAntipruritic, mild antiseptic, astringent.Mechanism of Action of CalamineCalamine is an anti-pruritics, which are used to relieve itching. Itching can be caused by physical irritation or chemical changes in the skin caused by disease, allergy, inflammation, side-effects of drugs, or reaction to irritant substances. It is a common symptom of skin disorders, e.g. eczema, and infection with lice or worms. Calamine is used as it has a cooling and soothing effect on the skin for symptomatic relief of the itching. It also contains the active ingredient zinc oxide, which has antiseptic properties and helps prevent infection from scratching.Pharmacokinets of CalamineN/AOnset of Action for CalamineN/ADuration of Action for CalamineN/AHalf Life of CalamineN/ASide Effects of Calamine1.Hives
3.Swelling of face, lips, tongue, or throat.
Contra-indications of Calamine1.Hypersensitivity to Calamine
2. Oozing skinSpecial Precautions while taking Calamine1.Do not use on extensive areas of skin for longer than 7 days
2.Avoid contact with mucous membranes and eyes
3.Discontinue if rash or burning sensation occurs
4.Avoid contact with eyes or mouth or nose.
Pregnancy Related InformationMay be usedOld Age Related InformationMay be usedBreast Feeding Related InformationMay be usedChildren Related InformationMay be usedIndications for Calamine1.To relieve the itching, pain, and discomfort of minor skin irritationsInteractions for CalamineN/ATypical Dosage for CalamineApply calamine directly to the skin and rub in gently, allowing to dry on your skin. Apply 3 to 4 times a day.Schedule of CalamineN/AStorage Requirements for CalamineStore the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.Keep out of the reach of children.
Effects of Missed Dosage of CalamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Do not double the dose.Continue the regular schedule.Effects of Overdose of CalamineGive supportive measures and sympptomatic treatment.
DiphenhydramineAbout DiphenhydramineFirst Generation H1 Antagonist ,Ethanolamine derivative, Antihistamine, antiemetic, antivertigo,sedative, and hypnotic.Mechanism of Action of DiphenhydramineAntiallergic action: It produces its antihistamine action by competitively blocking H1 receptors. It binds to the H1 receptors present in the smooth muscles of the gastrointestinal tract, bronchi, large blood vessels and uterus and inhibit Histamine induced allergic symptoms. They do not inhibit the release of Histamine.
Antivertigo and antiemetic actions: Central antimuscarinic actions of antihistamines are responsible for these effects of Diphenhydramine.
Parkinsonism: Acetyl choline receptor antagonists are used for the treatment of Parkinsonism. Diphenhydramine reduces the unbalanced cholinergic activity in striatum of parkinsonian patients.
Antitussive action: Diphenhydramine suppresses the cough reflex by a direct effect on the cough centre.
Migraine: Diphenhydramine is used in migraine due to its sedative as well as antiemetic actions.
Pharmacokinets of DiphenhydramineAbsorption: It is well absorbed after oral administration. Distribution: Diphenhydramine is widely distributed in the body including CNS in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: Excreted primarily in urineOnset of Action for Diphenhydramine15 minutesDuration of Action for Diphenhydramine6 - 8 hoursHalf Life of Diphenhydramine2.5 - 9 hoursSide Effects of Diphenhydramine1.Headache
14.Thickening of bronchial secretions.
Contra-indications of Diphenhydramine1.Hypersensitivity to Diphenhydramine
Special Precautions while taking Diphenhydramine1.Hypertension
4.Angle closure glaucoma
6.Urinary tract obstruction
7.Use with caution while operating machine, driving vehicle or activities requiring mental alertness
Pregnancy Related InformationUse with caution.Old Age Related InformationUse with caution.Breast Feeding Related InformationContraindicated.Children Related InformationUse with caution
Indications for Diphenhydramine1.Parkinson`s disease
Interactions for DiphenhydramineIncompatibility reported with amphotericin, cephalothine sodium, hydrocortisone, sodium succinate, some soluble barbiturates, some contrast media.Typical Dosage for DiphenhydramineAdult: 25 - 50 mg 3 - 4 times daily. Dosage should be individualised according to the needs and the response of the patient
Nonproductive cough: 100 mg / day in 4-6 times daily.
Insomnia: 50 mg at bed time
Children above 12 years: 25 - 50 mg 3 - 4 times daily. Dosage should be individualised according to the needs and the response of the patient
Nonproductive cough: 100 mg / day in 4-6 divided dose
Insomnia: 50 mg at bed time
Children age 2 -12 years: 12.5 - 25 mg 3 - 4 times daily. Dosage should be individualised according to the needs and the response of the patient.
Maximum dose: 300mg / day
Nonproductive cough: 6.25 - 12.5 mg in 4-6 times daily. Dosage should be individualised according to the needs and the response of the patient
Schedule of DiphenhydramineGStorage Requirements for DiphenhydramineStore at 15 - 30 degree C. Protect from heat, light and moisture. Keep out of the reach of children.Effects of Missed Dosage of DiphenhydramineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DiphenhydramineGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Hypotension can be counteracted by administration of vasopressors and seizure with Phenytoin or Diazepam.
CamphorAbout CamphorN/AMechanism of Action of CamphorCamphor acts as a rubefacient when it is rubbed on the skin and causes localized vasodilatation; which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and a mild local anaesthetic effect and relieves itching. When ingested in small amounts, it creates feelings of warmth and comfort in the epigastrium. Camphor acts as a local anesthetic on the respiratory passageways and causing cough suppression.Pharmacokinets of CamphorAbsorption: Well absorbed through the skin, Distribution: Widely distributed in the body and crosses the placenta, Metabolism: Metabolized in liver, Excretion: Excreted mainly through urine and a minor portion is excreted through lungs.Onset of Action for CamphorN/ADuration of Action for CamphorN/AHalf Life of CamphorN/ASide Effects of Camphor1.Gastric irritation
Contra-indications of Camphor1.Hypersensitivity to the drug
2.Should not applies to broken, injured, or burned skin
Special Precautions while taking Camphor1.Should not apply camphor directly in to or near the nostrils of small children or asthma patients
2.Prolonged use may lead to accumulation in adipose tissue
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with caution
Children (below 2 years): ContraindicatedIndications for Camphor1.Rubefacient
2.Ingredient in cough preparations
4. Ingredient in ointment or liniment to treat sprains; joint and muscle pain
5. As balm for chapped lips, cold sores
6.As an inhalant to relieve nasal, bronchial or upper respiratory congestion.
Interactions for CamphorN/ATypical Dosage for CamphorDosage individualized based on requirement and condition of the patient.
Topical: Rubbed on the throat and chest in a layer loosely covered with a warm dry cloth; up to thrice daily.
In vaporizer: Camphor (6.2%) in a hot steam vaporizer can be used by adding 1 tbsp of solution for each quart of cold water, or 1 tsp of solution for each pint, up to thrice daily.Schedule of CamphorN/AStorage Requirements for CamphorStore at a cool dry place in a well closed container. Protect from light and heat. Keep out of reach of children.Effects of Missed Dosage of CamphorTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CamphorProvide symptomatic treatment and supportive measures.
Ingestion: If camphor has been ingested recently, and the condition of the patient allows, perform gastric lavage. If only small amounts have been ingested, administer cathartics.
Inhalation: If camphor has been inhaled, remove patient from exposure, administer fresh air or oxygen, and establish respiration.
Topical: If there has been external contact with camphor, wash skin thoroughly with soap and water. Irrigate eyes with plenty of water.
In severe poisoning: Assist respiration in respiratory depression. Perform artificial respiration if required. Treat convulsions with diazepam or other suitable drugs. Protect the airway by endotracheal intubation or suitable measures, Perform gastric lavage and reduce absorption by administration of activated charcoal, and then a saline cathartic if required. Resin and charcoal haemoperfusion may be used in severe cases.
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