Trimethoprim Pharmacology

Trimethoprim

About Trimethoprim

Dihydrofolate reductase inhibitor, Pyrimidine derivative, Anti-infective(bacteriostatic antibiotic).

Mechanism of Action of Trimethoprim

Trimethoprim is a bacteriostatic antibiotic and acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid. Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleosides thymidine and uridine. Bacteria are unable to take up folic acid from the environment and are thus dependent on their own de novo synthesis.

Pharmacokinets of Trimethoprim

Absorption:It is rapidly and completely absorbed after oral administration.Distribution:It is widely distributed in the body.Half of the drug is distributed in protein bound form.Metabolism:About 20% is metabolised in the liver.Excretion:Most of the drug is excreted in urine.

Onset of Action for Trimethoprim

N/A

Duration of Action for Trimethoprim

N/A

Half Life of Trimethoprim

8 - 11 hours

Side Effects of Trimethoprim

1.Loss of appetite
2.Nausea
3.Vomiting
4.Diarrhoea
5.Abdominal pain
6.Abnormal taste
7.Swelling of the tongue.

Contra-indications of Trimethoprim

1.Hypersensitivity to Trimethoprim
2.Megaloblastic anaemia caused by folate deficiency

Special Precautions while taking Trimethoprim

1.Renal impairment
2.Hepatic impairment
3.Folate deficiency

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Use with caution
Below 2 years:Contraindicated

Indications for Trimethoprim

1.Urinary tract infections
2.Traveler`s diarrhea
3.Respiratory Infection

Interactions for Trimethoprim

N/A

Typical Dosage for Trimethoprim

200 mg/day in 2 divided doses for 10 days

Schedule of Trimethoprim

N/A

Storage Requirements for Trimethoprim

Store at 15 - 30 degree C.Protect from heat,light and moisturiser.Keep out of the reach of children.

Effects of Missed Dosage of Trimethoprim

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.Continue the regular schedule.Do not double the dose.

Effects of Overdose of Trimethoprim

Give supportive measures and symptomatic treatment.Drug can be removed from the body by gastric lavage.

Home Delivery for Trimethoprim in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including trimethoprim.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for trimethoprim and other medicines and health products. Home delivery services for trimethoprim may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take trimethoprim only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for trimethoprim before they complete the sale. You can get this information while placing the order for trimethoprim with the pharmacy.

Trimethoprim is a generic medicine name and there are several brands available for it. Some of the brands for trimethoprim might be better known than trimethoprim itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trimethoprim in stock, you can ask for one of the branded alternatives for trimethoprim.