Povidone Iodine Pharmacology

Povidone Iodine

About Povidone Iodine
Iodine preparation, External broad microbicidal spectrum antiseptic.
Mechanism of Action of Povidone Iodine
Povidone iodine is an iodophore antiseptic and is a microbicidal drug. It releases iodine from its complex and produces pharmacological actions. The released iodine produces antiseptic actions. Iodine is highly reactive with surrounding and has strong oxidizing effect on functional groups of amino acids (-NH 2, -SH etc.), Nucleotides, and fatty acids (double bond of unsaturated fatty acids). Interaction of Iodine with these groups in a cell results in disintegration of the cytoplasm, enzyme denaturation, loss of integrity in the bacterial cell membrane and fungal cell wall .These will leads to destruction of microbial protein and DNA and finally kills the microbes.
Pharmacokinets of Povidone Iodine
Absorption: It is poorly absorbed through intact skin but absorption is enhanced through denuded skin.
Onset of Action for Povidone Iodine
Duration of Action for Povidone Iodine
Half Life of Povidone Iodine
Side Effects of Povidone Iodine
1.Local irritation
Contra-indications of Povidone Iodine
1. Hypersensitivity to Povidone iodine and other preparations containing iodine
2. Thyroid disorders - goiter, hypothyroidism
3. Application to large areas of skin
4. Patient on Lithium therapy
Special Precautions while taking Povidone Iodine
1. Hepatic impairment
2. If irritation or redness develops stop the drug use
3. Avoid contact with eyes
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution.
Below 2 years: contraindicated
NEONATES: contraindicated
Indications for Povidone Iodine
As antiseptic in
1. Boils
2. Furunculosis
3. Burns
4. Ulcers
5. Otitis externa
6. Tinea infestations
7. Wound infections
8. Post surgical dressings
9. Cutaneous candidiasis
10. Trichomoniasis
11. Vaginal candidiasis
12. Oral candidiasis
13. Oral hygiene
Interactions for Povidone Iodine
Lab tests: May interfere with thyroid function tests.
Typical Dosage for Povidone Iodine
Ointment (5% w/w Povidone iodine), Cream (5% w/w Povidone iodine). Spray(5 - 10 % w / v Povidone iodine solution), Solution (5 - 7.5 % w/ v Povidone iodine solution) and Powder( 5% w/w Povidone iodine)
Thoroughly clean and dry the area. Apply the drug. Cover with a bandage.
Gargle solution:
Oral candidiasis: 1% mouthwash solution rinse mouth with this solution
Oral hygiene: 0.1 % of 10 ml solution (undiluted or diluted with equal quantity of warm water solution) rinse mouth with this for 30 seconds 4 times daily for 2 weeks
Surgical scrub: 7.5 % w/v solution
Wet hands with water. Pour about 1 teaspoonful of Scrub on the palm of the hand and spread over both hands and
scrub thoroughly for about 5 minutes.
Use a brush if desired. Clean thoroughly under fingernails.
Add a little water and develop copious suds. Rinse thoroughly under running water.
Repeat the entire procedure.

Vaginal candidiasis: 200 mg as pessaries. Insert 2 pessaries in vagina at night and continue for 2 weeks

Schedule of Povidone Iodine
Storage Requirements for Povidone Iodine
Store in a cool dry place. Protect from direct light and heat. Keep out of reach of children
Effects of Missed Dosage of Povidone Iodine
Apply the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Povidone Iodine
Give supportive measures and symptomatic treatment.

Home Delivery for Povidone Iodine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including povidone iodine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for povidone iodine and other medicines and health products. Home delivery services for povidone iodine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take povidone iodine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for povidone iodine before they complete the sale. You can get this information while placing the order for povidone iodine with the pharmacy.

Povidone Iodine is a generic medicine name and there are several brands available for it. Some of the brands for povidone iodine might be better known than povidone iodine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have povidone iodine in stock, you can ask for one of the branded alternatives for povidone iodine.