Povidone Iodine + Metronidazole Pharmacology
Povidone Iodine + Metronidazole
2. Thyroid disorders - goiter, hypothyroidism
3. Application to large areas of skin
4. Patient on Lithium therapy
2. If irritation or redness develops stop the drug use
3. Avoid contact with eyes
Below 2 years: contraindicated
5. Otitis externa
6. Tinea infestations
7. Wound infections
8. Post surgical dressings
9. Cutaneous candidiasis
11. Vaginal candidiasis
12. Oral candidiasis
13. Oral hygiene
Ointment (5% w/w Povidone iodine), Cream (5% w/w Povidone iodine). Spray(5 - 10 % w / v Povidone iodine solution), Solution (5 - 7.5 % w/ v Povidone iodine solution) and Powder( 5% w/w Povidone iodine)
Thoroughly clean and dry the area. Apply the drug. Cover with a bandage.
Oral candidiasis: 1% mouthwash solution rinse mouth with this solution
Oral hygiene: 0.1 % of 10 ml solution (undiluted or diluted with equal quantity of warm water solution) rinse mouth with this for 30 seconds 4 times daily for 2 weeks
Surgical scrub: 7.5 % w/v solution
Wet hands with water. Pour about 1 teaspoonful of Scrub on the palm of the hand and spread over both hands and
scrub thoroughly for about 5 minutes.
Use a brush if desired. Clean thoroughly under fingernails.
Add a little water and develop copious suds. Rinse thoroughly under running water.
Repeat the entire procedure.
Vaginal candidiasis: 200 mg as pessaries. Insert 2 pessaries in vagina at night and continue for 2 weeks
Metabolism: Metabolized in liver by oxidation & glucuronide conjugation, Excretion: Excreted in urine.
7.Looseness of stool.
8.Peripheral neuropathy &CNS effects.
16.Thrombophlebitis at site of injection
4.Use cautiously along with other hepatotoxic drugs & In visual field changes
First trimester:contra indicated
4.Pseudo membranous enterocolitis
5.Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis
6.Helicobacter pylori infections
Alcohol: A disulfiram-like reaction. Abdominal cramps, nausea, vomiting, headache & flushing.
Disulfiram: Acute psychotic reaction or confusional state.
Phenobarbital & Phenytoin: Increased metabolism of metronidazole resulting in decreased efficacy.
Lithium: Increased lithium levels and toxicity.
Flurouracil: Increased toxicity of flurouracil.
Lab tests: May interfere with chemical analysis for AST,SGOT, ALT, SGPT, LDH, triglycerides and hexokinase glucose. Zero values may occur.
Amoebiasis:400 to 800 mg 8hourly for 5 to 10days depending up on the severity of infection
In severe infections and liver abscess: 1gm as slow I.V. infusion followed by 0.5 gm twice daily till oral therapy is started
Giardiasis:200mg 8hourly for 1week or 2gm/day for 3days or I.V.500mg thrice daily
Trichomonas vaginitis: 400mg 8 hourly for a week or 2gm once daily for a week.
Male partner should be concurrently treated with the drug
Pseudo membranous enterocolitis:800 mg 8hourly
Anaerobic bacterial infections after surgery, Brain abscess, & Endocarditis:400 to 800 mg 8hourly
In severe cases: 15mg/kg I.V. infusion for 1hour followed by 7.5mg/kg 4 times daily till oral therapy is substituted
Helicobacter pylori infections:400mg 8hourly along with amoxicillin/clarithromycin and a proton pump inhibitor
Ulcerative gingivitis:200 to 800mg 8hourly
Amoebiasis: 30 to 50mg/kg/day for 5to10 days.
Giardiasis:10 to 15mg/kg/day thrice daily
Children (below 12years): 7.5mg/kg I.V.
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